Predictors of late post-stroke asthenia
https://doi.org/10.30629/2658-7947-2026-31-2-23-28
Abstract
The objective of the study was to analyze the clinical and laboratory factors in the acute period of ischemic stroke (IS) that predispose to the development of various manifestations of asthenia (pathological fatigue) 6 months later.
Material and methods. The data of 98 patients recruited in the acute period of IS and who agreed to a telephone interview 6 months later were analyzed. Post-stroke asthenia (PSA) was assessed using the subjective scale for assessing fatigue (MFI-20)). The severity of stroke (National Institutes of Health Stroke Scale (NIHSS), Rankin Scale, Rivermead Mobility Index), cognitive impairment, apathy, depression, anxiety, and laboratory and instrumental data obtained in acute period of stroke were registered. Linear regression analysis was performed to identify predictors of the severity of various manifestations of late-onset PSA.
Results. Cognitive decline was an independent predictor of the severity of general fatigue. The severity of stroke was a significant predictor of reduced activity and physical fatigue. Mobility impairment on the Rivermead scale was a predictor of decreased motivation. The severity of mental fatigue was associated with increased anxiety.
Conclusion. The data obtained demonstrate the clinical and pathogenetic heterogeneity of various manifestations of late PSA. This determines the need to develop differentiated approaches to the prevention of PSA.
Supporting agencies: The work was carried out using funds from the state assignment of the Ministry of Health of the Russian Federation; R&D registration number 124121800005-6.
About the Authors
A. I. Akhmetova
G.G. Kuvatov Republican Clinical Hospital
Russian Federation
Russian Federation
Ufa
M. A. Kutlubaev
Bashkir State Medical University
Russian Federation
Russian Federation
Ufa
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Review
For citations:
Akhmetova A.I., Kutlubaev M.A. Predictors of late post-stroke asthenia. Russian neurological journal. 2026;31(2):23-28. (In Russ.) https://doi.org/10.30629/2658-7947-2026-31-2-23-28
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