r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2026-31-2-23-28r-n-j-824Research ArticleОБЗОРЫREVIEWSПредикторы поздней постинсультной астенииPredictors of late post-stroke astheniahttps://orcid.org/0000-0002-9769-869XАхметоваА. И.AkhmetovaA. I.

Уфа

Ufa

albinak039@gmail.comhttps://orcid.org/0000-0003-1001-2024КутлубаевМ. А.KutlubaevM. A.

Уфа

Ufa

mansur.kutlubaev@yahoo.comРеспубликанская клиническая больница им. Г.Г. КуватоваРоссияG.G. Kuvatov Republican Clinical HospitalRussian FederationБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian Federation2026170620263122328Copyright © Ахметова А.И., Кутлубаев М.А., 20262026Ахметова А.И., Кутлубаев М.А.Akhmetova A.I., Kutlubaev M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/824Цель исследования

Цель исследования: проанализировать клинические и лабораторные факторы в остром периоде ишемического инсульта (ИИ), предрасполагающие к развитию различных проявлений астении (патологической усталости) через 6 мес. после инсульта.

Материал и методы

Материал и методы. Проанализированы данные 98 пациентов, обследованных в остром периоде ИИ и согласившихся на телефонное интервью через 6 мес. Постинсультная астения (ПИА) оценивалась с применением субъективной шкалы оценки астении (Multidimensional Fatigue Inventory (MFI-20)). Регистрировались тяжесть инсульта (по шкале инсульта Национальных институтов здоровья (NIHSS), модифицированной шкале Рэнкина, индексу мобильности Ривермид), выраженность нарушений когнитивных функций, апатии, депрессии, тревоги в остром периоде инсульта, а также лабораторные данные. Для выявления предикторов тяжести различных проявлений поздней ПИА проводился линейный регрессионный анализ.

Результаты

Результаты. Независимым предиктором тяжести общей астении было когнитивное снижение. Тяжесть инсульта являлась значимым предиктором развития пониженной активности и физической астении. Предиктором снижения мотивации выступало нарушение мобильности по шкале Ривермид. Выраженность психической астении была связана с повышенной тревожностью в остром периоде инсульта.

Заключение

Заключение. Полученные данные демонстрируют клинико-патогенетическую гетерогенность различных проявлений поздней ПИА. Это определяет необходимость разработки дифференцированных подходов к профилактике ПИА.

The objective of the study was to analyze the clinical and laboratory factors in the acute period of ischemic stroke (IS) that predispose to the development of various manifestations of asthenia (pathological fatigue) 6 months later.

Material and methods

Material and methods. The data of 98 patients recruited in the acute period of IS and who agreed to a telephone interview 6 months later were analyzed. Post-stroke asthenia (PSA) was assessed using the subjective scale for assessing fatigue (MFI-20)). The severity of stroke (National Institutes of Health Stroke Scale (NIHSS), Rankin Scale, Rivermead Mobility Index), cognitive impairment, apathy, depression, anxiety, and laboratory and instrumental data obtained in acute period of stroke were registered. Linear regression analysis was performed to identify predictors of the severity of various manifestations of late-onset PSA.

Results

Results. Cognitive decline was an independent predictor of the severity of general fatigue. The severity of stroke was a significant predictor of reduced activity and physical fatigue. Mobility impairment on the Rivermead scale was a predictor of decreased motivation. The severity of mental fatigue was associated with increased anxiety.

Conclusion

Conclusion. The data obtained demonstrate the clinical and pathogenetic heterogeneity of various manifestations of late PSA. This determines the need to develop differentiated approaches to the prevention of PSA.

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The authors declare that there are no conflicts of interest present.