Сlinical Practice of Ipidacrinum Application in Tunnel Neuropathy
https://doi.org/10.30629/2658-7947-2020-25-2-42-46
Abstract
An observation of a 52-year-old patient with tunnel neuropathy (TN) of the median nerve with a positive effect achieved from the use of the anticholinesterase preparation ipidacrinum, is presented. In the observation, a decrease in the severity of neuropathic pain syndrome, an improvement in neurophysiological parameters and emotional state are noted after 4 weeks of treatment. Possible mechanisms of the effects of ipidacrinum application in TN are discussed.
About the Authors
Yu. A. Merkulov
Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine; 2Scientific Research Institute of General Pathology and Pathophysiology
Russian Federation
Moscow
Russian Federation
Moscow
A. M. Magomedova
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University)
Russian Federation
Moscow
Russian Federation
Moscow
A. M. Gamburg
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University)
Russian Federation
Moscow
Russian Federation
Moscow
D. M. Merkulova
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University); B.M. Guekht Neurology Center, Central Clinical Hospital «RZD-Medicine»
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Yakhno N.N., Parfenov V.A. Chastnaya nevrologiya. Moskva: MIA. 2006. (In Russian).
2. Merkulov Yu.A, Danilov A.B., Merkulova D.M. Compressive neuropathies. New approaches to therapy. Lechenie zabolevaniy nervnoi systemi. 2009;2(2):25–31. (In Russian).
3. Kipervas I.P. Tunnel'nye sindromy. M: N'yudiamed. 2010:17. (In Russian).
4. Barinov A.N. Complex treatment of tunnel neuropathy of pelvic belt with pathology of the lumbar division of thespine. Lechashchii vrach. 2013;7:87–92. (In Russian). https://www.lvrach.ru/2013/07/15435761/.
5. Al'-Zamil' M.Kh. Karpal'nyi sindrom. Klinicheskaya nevrologiya. 2008;1:41–45. (In Russian). https://elibrary.ru/download/elibrary_13759213_37501199.pdf.
6. Danilov A.B., Danilov Al.B. Upravlenie bol'yu. Biopsikhosotsial'nyi podkhod. M.: AMM PRESS. 2014.(In Russian).
7. Strokov I.A., Golovacheva V.A., Brand P.Ja. Pregabalin v lechenii bolevyh sindromov. Medicinskij sovet. 2013;4:69–73. (In Russian).
8. Oganov R.G., Denisov I.N., Simanenkov V.I., Bakulin I.G., Zaharova N.V., Boldueva S.A., Barbarash O.L., Garganeeva N.P., Doshhicin V.L., Drapkina O.M., Dudinskaja E.N., Kotovskaja Ju.V., Lila A.M., Mamedov M.N.O., Mardanov B.U., Miller O.N., Petrova M.M., Pozdnjakov Ju.M., Runihina N.K., Sajganov S.A., Tarasov A.V., Tkacheva O.N., Urinskij A.M., Shal'nova S.A. Komorbidnaja patologija v klinicheskoj praktike. Klinicheskie rekomendacii. Kardiovaskuljarnaja terapija i profilaktika. 2017;16(6):5–56. (In Russian).
9. Kadyrova L.R., Akarachkova E.S., Kerimova K.S., Kotova O.V., Lebedeva D.I., Orlova A.S., Tkachev A.M., Travnikova E.V., Careva E.V. Mul'tidisciplinarnyj podhod k pacientu s hronicheskoj bol'ju. RMZh. 2018;7:28–32. (In Russian).
10. Mozolevsky Yu.V, Barinov A.N. Combination treatment for tunnel neuropathies of the lower extremities. Neurology, neuropsychiatry, psychosomatics. 2013;(4):10–20. (In Russian). DOI: 10.14412/2074-2711-2013-2449.
11. Kamchatnov PR, Abusueva BA, Kazakov AY. Alpha-lipoic Acid in Treatment of Nervous System Diseases. Zh. Nevrol. Psikhiatr. im S.S. Korsakova. 2014;114(10):131–135. (In Russian).
12. Shavlovskaja O.A. Tioktovaja kislota: antioksidantnaja terapija nevrologicheskih zabolevanij. RMZh. 2014;22(13):960–965. (In Russian).
13. Strokov I.A., Phokina A.S. α-Lipoic acid as the main pharmacological drug for in- and outpatient treatment of diabetic polyneuropathy. Zh. Nevrol. Psikhiatr. Im S.S. Korsakova. 2017;117(3):50–55. (In Russian). doi:10.17116/jnevro20171173150-55.
14. Katunina E.A., Avanesova O.V., Pestovskaya O.R., Abdrakhmanova E.K., Bezdol'nyi Yu.N. Use of acetylcholine esterase inhibitors in the treatment of peripheral nervous system diseases. Farmateka. 2009;189(15):66–69. (In Russian). https://lib.medvestnik.ru/articles/Primenenie-ingibitorov-acetilholinesterazy-pri-lechenii-zabolevanii-perifericheskoi-nervnoi-sistemy.html.
15. Zhivolupov S.A., Samartsev I.N. Central mechanisms of therapeutic effectiveness of neuromidin in the treatment of peripheral nerve lesions. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2010;110(3):25–30. (In Russian). https://mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatriiim-s-s-korsakova/2010/3/downloads/ru/031997-7298201035.
16. Damulin I.V., Zhivolupov S.A., Zaitsev O.S., Maksimova M.Yu., Markin S.P., Samartsev I.N., Sanadze A.G., Strokov I.A. Neiromidin v klinicheskoi praktike. 2-e izd., pererabotannoe i dopolnennoe. M.: OOO Meditsinskoe informatsionnoe agentstvo. 2016;56. (In Russian).
17. Avakyan G.N., Avakyan G.G. A clinical-electroneuromyographic study of the efficacy of ipidacrine in patients with mononeuropathies. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2015;115(9):9–17. (In Russian). https://doi.org/10.17116/jnevro20151159117-22.
18. Magomedova A.M., Merkulov Yu.A., Biglova A.N., Smolentseva K.V., Merkulova D.M. An outpatient with hand numbness: old prejudices, new strategies of differential diagnosis and treatment. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(3):16–23. (In Russian). DOI:10.17116/jnevro201911903116.
19. Gur'eva I.V., Davydov O.S. Nevropaticheskaja bol' pri saharnom diabete: prichiny, diagnostika i obzor mezhdunarodnyh rekomendacij i algoritmov lechenija. Consilium medicum. 2013;15(4):14–20. (In Russian).
20. Barulin A.E., Kurushina O.V., Kalinchenko B.M., Chernovolenko E.P. Hronicheskaja bol' i depressija. Lekarstvennyj vestnik. 2016;10(1):3–10. (In Russian).
21. Tabeeva G.R. Komorbidnost' hronicheskoj boli i depressii u nevrologicheskih bol'nyh. Nevrologija, nejropsihiatrija, psihosomatika. 2013;(3):4–12. (In Russian).
22. Agüera L., Failde I., Cervilla J.A., Díaz-Fernández P., Mico J.A. Medically unexplained pain complaints are associated with underlying unrecognized mood disorders in primary care. BMC Fam. Pract. 2010;11:17. doi:10.1186/1471-2296-11-17.
23. Kukushkin M.L. Mehanizmy razvitija hronicheskoj boli. Podhody k profilaktike i lecheniju. Consilium Medicum. 2017;19(2):110–117. (In Russian).
24. Koreshkina M.I. Nevropaticheskaja bol'. Problemy i reshenija. Nervnye bolezni. 2016;4:3–37. (In Russian).
25. Bair M.J., Wu J., Damush T.M., Sutherland J.M., Kroenke K. Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients. Psychosom. Med. 2008;70(8):890–897. doi:10.1097/PSY.0b013e318185c510.
26. Williams D.A. The importance of psychological assessment in chronic pain. Curr. Opin. Urol. 2013;23(6):554–559. doi:10.1097/MOU.0b013e3283652af1.
27. Danilov A.B., Danilov A.B. Upravlenie bol'ju. Biopsihosocial'nyj podhod. M.: AMM PRESS. 2014. (In Russian).
28. Gupta S.K., Benstead T.J. Symptoms experienced by patients with carpal tunnel syndrome. Can. J. Neurol. Sci. 1997;24(4):338–342. doi:10.1017/s0317167100033023.
29. American Academy of Orthopaedic Surgeons. Management of Carpal Tunnel Syndrome. Evidence-Based Clinical Practice Guideline. www.aaos.org/ctsguideline. Published February 29, 2016.
30. Huisstede B.M., Fridén J., Coert J.H., Hoogvliet P., European HANDGUIDE Group. Carpal tunnel syndrome: hand surgeons, hand therapists, and physical medicine and rehabilitation physicians agree on a multidisciplinary treatment guideline — results from the European HANDGUIDE Study. Arch. Phys. Med. Rehabil. 2014;95:2253–2263.
31. Caliandro P., La Torre G., Padua R., Giannini F., Padua L. Treatment for ulnar neuropathy at the elbow. Cochrane Database of Systematic Reviews. 2016;11:6839. DOI: 10.1002/14651858.CD006839.pub4.
32. Gilverg A.S., Parfenov V.A., Evzikov G.Y. Questions of diagnosis and treatment of carpal tunnel syndrome. Neurology, neuropsychiatry, psychosomatics. 2019;11(2):46–51. (In Russian). https://doi.org/10.14412/2074-2711-20192S-46-51.
33. Sharov M.N., Stepanchenko O.A., Suslina Z.A. Sovremennyi opyt primeneniya antikholinesteraznykh preparatov v nevrologii. Lechashchii vrach. 2008;5:91–94. (In Russian). http://amp.lvrach.ru/2008/05/5161513.
Review
For citations:
Merkulov Yu.A., Magomedova A.M., Gamburg A.M., Merkulova D.M. Сlinical Practice of Ipidacrinum Application in Tunnel Neuropathy. Russian neurological journal. 2020;25(2):42-46. (In Russ.) https://doi.org/10.30629/2658-7947-2020-25-2-42-46
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