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Features of therapy for a 12-year-old child with severe combined trauma

https://doi.org/10.30629/2658-7947-2025-30-3-61-65

Abstract

The article presents a clinical observation of the treatment of severe combined trauma in a 12-year-old child. Due to the presence of brainstem disorders and prolonged impairment of consciousness after surgical treatment and two weeks after the injury, a solution of cytoflavin (20 ml/day) was used intravenously by drip (off  label) in the conservative treatment regimen with a positive effect. The neuroprotector cytoflavin may have a positive effect in children with severe TBI not only during the “therapeutic window” period, but also later. The results obtained may serve as a basis for further research.

About the Authors

V. F. Byankin
Ivano-Matreninsk City Children’s Clinical Hospital
Russian Federation

Irkutsk



A. V. Livadarov
Ivano-Matreninsk City Children’s Clinical Hospital
Russian Federation

Irkutsk



G. S. Zhdanovich
Ivano-Matreninsk City Children’s Clinical Hospital
Russian Federation

Irkutsk



A. S. Popov
Ivano-Matreninsk City Children’s Clinical Hospital
Russian Federation

Irkutsk



References

1. Traumatic brain injury in children. Clinical recommendations, M., 2022, 94 p ID: 493. As of 09/30/2022 on the website of the Ministry of Health of the Russian Federation https://minzdrav.gov.ru/

2. Gregory W J Hawryluk 1, Andres M Rubiano 2 3, Annette M Totten 4, Cindy O’Reilly 4, Jamie S Ullman 5, Susan L Bratton 6, Randall Chesnut 7, Odette A Harris 8, Niranjan Kissoon 9, Lori Shutter 10, Robert C Tasker 11, Monica S Vavilala 7, Jack Wilberger 12, David W Wright 13, Angela Lumba-Brown 8, Jamshid Ghajar 8 Guidelines for the Management of Severe Traumatic Brain Injury: 2020 Update of the Decompressive Craniectomy Recommendations Neurosurgery. 2020 Sep 1;87(3):427–434. doi: 10.1093/neuros/nyaa278.

3. Semenova Zh. B., Melnikov A.V., Savvina I.A., Lekmanov A.U., Khachatryan V.A., Gorelyshev S.K. Recommendations for the treatment of children with traumatic brain injury. Russian Bulletin of Pediatric Surgery, Anesthesiology and Traumatology. 2016; T. VI (No. 2):112–13. doi: 10.17816/psaic258

4. Krylov V.V. Surgery of severe traumatic brain injury. Edited by Krylov V.V., Talypov A.E., Levchenko O.V. Moscow, 2019. 647 p

5. Focal brain injury. Clinical guidelines, M., 2022, 83 p. https://legalacts.ru/doc/klinicheskie

6. Kochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS et al. Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies Pediatr Crit Care Med. 2019 Mar;20(3):269–279. doi: 10.1097/PCC.0000000000001737.

7. Treatment of children with traumatic brain injury. Clinical recommendations M., 2015, 36 p.

8. Lavrik S.Yu., Shprakh V.V., Domitrak S.V., Borisov A.S. Use of cytofl avin in children of preschool and early school age with consequences of perinatal hypoxic lesions of the central nervous system. Journal of Neurology and Psychiatry named after S.S. Korsakov. 2016;10:34–37. doi: 10.17116/jnevro201611610134-37.

9. Kovalchuk V.V., Zueva I.B., Nesterin K.V., et al. The use of the drug cytofl avin in neonatology and pediatrics as a factor in increasing the eff ectiveness of therapy for patients with central nervous system damage of various etiologies. S.S. Korsakov Journal of Neurology and Psychiatry. 2018; Issue 2 (5):46–50. https://doi.org/10.17116/jnevro20181185246

10. Salikhova K. Sh., Agzamkhodzhaeva B.U., Abdurakhmanova F.R., Ishniyazova N.D., Salikhova S.M. Neuroprotective eff ect of Cytofl avin in the treatment of premature infants with hypoxic-ischemic encephalopathy. Korsakov Journal of Neurology and Psychiatry. 2024;124(9):68 72. https://doi.org/10.17116/jnevro202412409168

11. Kan T.V., Simonova N.V., Kan A.Ch. Effi ciency of cytoflavin in optimizing pharmacotherapy for traumatic brain injury. Russian Neurological Journal. 2022;27(2):85–92. https://doi.org/10.30629/2658-7947-2022-27-2-85-92

12. Byankin V.F., Zhdanovich G.S., Livadarov A.V., Popov A.S. Severe traumatic brain injury with damage to the posterior cranial fossa in an adolescent. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(8):113117) https://doi.org/10.17116/jnevro2024124081113


Review

For citations:


Byankin V.F., Livadarov A.V., Zhdanovich G.S., Popov A.S. Features of therapy for a 12-year-old child with severe combined trauma. Russian neurological journal. 2025;30(3):61-65. (In Russ.) https://doi.org/10.30629/2658-7947-2025-30-3-61-65

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ISSN 2658-7947 (Print)
ISSN 2686-7192 (Online)