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Frontal variant of Аlzheimer's disease
K. V. Nevzorova,
Yu. A. Shpilyukova,
N. Yu. Abramycheva,
A. A. Shabalina,
E. Yu. Fedotova,
S. N. Illarioshkin https://doi.org/10.30629/2658-7947-2024-29-6-56-63
Abstract
Alzheimer’s disease (AD) is a chronic neurodegenerative disease, that is the most common cause of dementia. Late on-set AD is usually associated with the classic picture of short-term memory deficits, while early onset AD demonstrates atypical symptoms. The frontal variant is the rarest non-amnestic AD phenotype, which associated with selective neurodegeneration in frontal control networks, which is confirmed by the presence of biomarkers of amyloid pathology. The clinical picture includes a wide variety of symptoms, including disinhibition, apathy, compulsive behavior and executive dysfunction, which often leads to difficulties in making a differential diagnosis with the behavioral variant of frontotemporal dementia) and, as a result, underestimation of the true prevalence of AD. The article provides a brief review of modern literature and a description of two clinical cases of the frontal variant of AD, confirmed by the study of cerebrospinal fluid biomarkers.
About the Authors
K. V. Nevzorova
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
Yu. A. Shpilyukova
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
N. Yu. Abramycheva
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
A. A. Shabalina
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
E. Yu. Fedotova
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
S. N. Illarioshkin
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
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For citations:
Nevzorova K.V., Shpilyukova Yu.A., Abramycheva N.Yu., Shabalina A.A., Fedotova E.Yu., Illarioshkin S.N. Frontal variant of Аlzheimer's disease. Russian neurological journal. 2024;29(6):56-63. (In Russ.) https://doi.org/10.30629/2658-7947-2024-29-6-56-63
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