Еarly diagnosis of multiple sclerosis: experience with the use of class G oligoclonal immunoglobulin
https://doi.org/10.30629/2658-7947-2021-26-3-34-39
Abstract
The article presents the literature review and our experience in early diagnosis of multiple sclerosis based on the updated McDonald criteria of 2017. The study included 256 patients with clinic symptoms of probable idiopathic infl ammatory demyelinating disease, including rare and atypical forms of demyelination. As a result of the study the sensitivity and specifi city of the determination of oligoclonal immunoglobulin G in the population of Rostov-on-Don was described for the fi rst time, including dependence of the duration of the disease. The relationship of clinical and MRI features of the fi rst attack of the disease with the probability of determining oligoclonal IgG in the cerebrospinal fl uid is refl ected
About the Authors
Z. A. Goncharova
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
Y. Y. Pogrebnova
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
N. M. Yarosh
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
S. M.M. Sehweil
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
References
1. Hartung H.P., Montalban X., Sorensen P.S., Vermersch P., Olsson T. Principles of a new treatment algorithm in multiple sclerosis. Expert Rev. Neurotherap. 2011;11(3):351–362. https://doi.org/10.1586/ern.11.15
2. Thompson A.J., Banwell B.L., Barkhov F., Carroll W.M., Coetzee T., Comi G. et al. Diagnosis of multiple sclerosis: 2017 revisions of McDonald criteria. Lancet Neurol. 2017;17:162–173. https://doi.org/10.1016/S1474-4422 (17)30470-2
3. Ziemssen T., Ziemssen F. The role of the humoral immune system in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Autoimmun. Rev. 2005;4:460–467. https://doi.org/10.1016/j.autrev.2005.03.005
4. Fust G. The role of the Epstein-Barr virus in the pathogenesis of some autoimmune disorders — similarities and diff erences. Journal of Microbiology and Immunology. 2011;1(4):267–278. https://doi.org/10.1556/eujmi.1.2011.4.2
5. Owens G.P., Gilden D., Burgoon M.P., Xiaoli Y., Jeff rey L. Bennett Viruses and multiple sclerosis. The Neuroscientist. 2011;17(6):659–676. https://doi.org/10.1177/1073858410386615
6. Reiber H., Felgenhauer K. Protein transfer at the blood cerebrospinal fl uid barrier and the quantitation of the humoral immune response within the central nervous system. Clin. Chim. Acta. 1987;163:319–328. https://doi.org/10.1016/0009-8981 (87)90250-6.
7. Idiman E., Ozakbas S., Dogan Y., Kosehasanogullari G. The signifi cance of oligoclonal bands in multiple sclerosis: Relevance of demographic and clinical features, and immunogenetic backgrounds. J. Neuroimmunol. 2009;212:121–124. https://doi.org/10.1016/j.jneuroim.2009.04.014
8. Schwenkenbecher P., Sarikidi A., Wurster U., Bronzlik P., Sühs K.W., Raab P. et al. McDonald criteria 2010 and 2005 compared: persistence of high oligoclonal band prevalence despite almost doubled diagnostic sensitivity. Int. J. Mol. Sci. 2016;17:1592. https://doi.org/10.3390/ijms17091592
9. Kuhle J., Disanto G., Dobson R., Adiutori R., Bianchi L., Topping J. et al. Conversion from clinically isolated syndrome to multiple sclerosis: a large multicentre study. Mult. Scler. 2015;21:1013–1024. https://doi.org/10.1177/1352458514568827
10. Schwenkenbecher P., Sarikidi A., Bönig L., Wurster U., Bronzlik P., Sühs K.W. et al. Clinically isolated syndrome according to McDonald 2010: intrathecal IgG synthesis still predictive for conversion to multiple sclerosis. Int. J. Mol. Sci. 2017;18:2061. https://doi.org/10.3390/ijms18102061
11. Polman C.H., Reingold S.C., Banwell B., Clanet M., Cohen J.A., Filippi M. et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 2011;69:292–302. https://doi.org/10.1002/ana.22366
12. Strupp M., Katsarava Z. Post-lumbar puncture syndrome and spontaneous low CSF. pressure syndrome. Nervenarzt. 2009;80(12):1509–1519. https://doi.org/10.1007/s00115-009-2833-y
13. Owens G.P., Bennett J., Lassmann H., O’Connor K., Ritchie A., Shearer A. et al. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fl uid. Annals of Neurology. 2009;65(6):639–649. https://doi.org/10.1002/ana.21641
14. Bourahoui A., de Seze J., Guttierez R., Onraed B., Hennache B., Ferriby D. et al. CSF isoelectrofocusing in a large cohort of MS and other neurological diseases. Eur. J. Neurol. 2004;11(8):525–529. https://doi.org/10.1111/j.1468-1331.2004.00822.x
15. Heussinger N., Kontopantelis E., Gburek-Augustat J., Jenke A., Vollrath G., Korinthenberg R. et al. Oligoclonal bands predict multiple sclerosis in children with optic neuritis. Ann. Neurol. 2015;77(6):1076–82. https://doi.org/10.1002/ana.24409
16. Darnell R.B., Jerome B., Posner M.D. Paraneoplastic Syndromes. 2011;467. https://doi.org/10.1016/B0-44-306557-8/50180-5
17. Ponomarev B.B., Selitsky M.M., Ivanchik G.I., Mezina E.V. Innovative biomarkers of autoimmune diseases of the nervous system. Medical News. 2016;1:3–8. (In Russian).
Review
For citations:
Goncharova Z.A., Pogrebnova Y.Y., Yarosh N.M., Sehweil S.M. Еarly diagnosis of multiple sclerosis: experience with the use of class G oligoclonal immunoglobulin. Russian neurological journal. 2021;26(3):34-39. (In Russ.) https://doi.org/10.30629/2658-7947-2021-26-3-34-39
Views:
526
Email this article 