r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2021-26-3-34-39r-n-j-185Research ArticleИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL RESEARCHES AND CASE REPORTSРанняя диагностика рассеянного склероза: опыт использования олигоклонального иммуноглобулина класса GЕarly diagnosis of multiple sclerosis: experience with the use of class G oligoclonal immunoglobulinhttps://orcid.org/0000-0001-7093-9548ГончароваЗ. А.GoncharovaZ. A.

Гончарова Зоя Александровна

Ростов-на-Дону

Rostov-on-Don

centrms@mail.ruhttps://orcid.org/0000-0002-7112-767XПогребноваЮ. Ю.PogrebnovaY. Y.

Ростов-на-Дону

Rostov-on-Don

3ay40n0k@mail.ruhttps://orcid.org/0000-0002-4616-0750ЯрошН. М.YaroshN. M.

Ростов-на-Дону

Rostov-on-Don

yarosh-nats@mail.ruhttps://orcid.org/0000-0003-3942-7442СехвейлС. M.M.SehweilS. M.M.

Ростов-на-Дону

Rostov-on-Don

salahsehweil@yandex.ruФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииРоссияRostov State Medical UniversityRussian Federation2021210720212633439Copyright © Гончарова З.А., Погребнова Ю.Ю., Ярош Н.М., Сехвейл С.M., 20212021Гончарова З.А., Погребнова Ю.Ю., Ярош Н.М., Сехвейл С.M.Goncharova Z.A., Pogrebnova Y.Y., Yarosh N.M., Sehweil S.M.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/185

В статье представлены данные литературы и собственный опыт ранней диагностики рассеянного склероза на основании обновленных критериев McDonald 2017 г. В исследование включено 256 пациентов с клиникой вероятного идиопатического воспалительного демиелинизирующего заболевания, в том числе с редкими и нетипичными формами демиелинизации. В результате исследования описана чувствительность и специфичность определения олигоклонального иммуноглобулина G в популяции г. Ростова-на-Дону, в том числе в зависимости от длительности заболевания. Отражена связь клинических и МРТ-особенностей первой атаки заболевания с вероятностью определения олигоклонального IgG в ликворе.

The article presents the literature review and our experience in early diagnosis of multiple sclerosis based on the updated McDonald criteria of 2017. The study included 256 patients with clinic symptoms of probable idiopathic infl ammatory demyelinating disease, including rare and atypical forms of demyelination. As a result of the study the sensitivity and specifi city of the determination of oligoclonal immunoglobulin G in the population of Rostov-on-Don was described for the fi rst time, including dependence of the duration of the disease. The relationship of clinical and MRI features of the fi rst attack of the disease with the probability of determining oligoclonal IgG in the cerebrospinal fl uid is refl ected

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The authors declare that there are no conflicts of interest present.