INFLUENCE OF SINGLE NUCLEOTIDE POLYMORPHISMS OF “ZINC FINGERS” PROTEINS GENES ON MULTIPLE SCLEROSIS
https://doi.org/10.30629/2658-7947-2019-24-3-19-23
Abstract
The genes ZFAT and ZFHX4 encoding the zinc finger proteins were previously identified as predisposing to autoimmune pathology and various cancer diseases, as well as influencing on therapeutic effect of interferonbeta in patients with multiple sclerosis. The aim of the study is to determine the associations of single nucleotide polymorphisms rs11787532 ZFHX4 and rs733254 ZFAT and development and severity of clinical manifestations of multiple sclerosis in Perm krai. A significant predominance of the C/A genotype of rs733254 ZFAT gene, and GC and CC haplotypes in people with multiple sclerosis was found. The association of single nucleotide polymorphisms with the severity of clinical manifestations of multiple sclerosis was not detected.
Supporting agencies: The study was supported by U.M.N.I.K. grant of Federal State Budgetary Institution “Innovation Promotion Fund”, contract №13195GU / 2018.
About the Authors
E. E. Arbuzova
E.A.Vagner Perm State Medical University
Russian Federation
post-graduate student of the Department of Neurology named after V.P.Pervushin
Russian Federation
post-graduate student of the Department of Neurology named after V.P.Pervushin
N. V. Selyanina
E.A.Vagner Perm State Medical University
Russian Federation
Russian Federation
A. V. Krivtsov
FBSI FSC Medical and Preventive Health Risk Management Technologies
Russian Federation
Russian Federation
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Review
For citations:
Arbuzova E.E., Selyanina N.V., Krivtsov A.V. INFLUENCE OF SINGLE NUCLEOTIDE POLYMORPHISMS OF “ZINC FINGERS” PROTEINS GENES ON MULTIPLE SCLEROSIS. Russian neurological journal. 2019;(3):19-23. (In Russ.) https://doi.org/10.30629/2658-7947-2019-24-3-19-23
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