Serotonin Theory of Depression: Modern View
https://doi.org/10.30629/2658-7947-2020-25-3-40-44
Abstract
In development of the «serotonin» hypothesis of depression put forward by I.P. Lapin and G.F. Oxenkrug in 1969, the combination of the two factors is proposed which are responsible for depression formation: reduced “basal” 5-HT cerebral level and excessive duration of early morning REM sleep periods during which the release of cerebral serotonin ceases altogether. As a means of prevention and treatment, not the deprivation, but rather fragmentation of REM sleep is proposed, which is much easier for patients to tolerate.
Supporting agencies: This work was supported by the Russian Science Foundation (project №17-15-01433).
About the Author
V. M. Kovalzon
Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences
Russian Federation
Moscow
Russian Federation
Moscow
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For citations:
Kovalzon V.M. Serotonin Theory of Depression: Modern View. Russian neurological journal. 2020;25(3):40-44. (In Russ.) https://doi.org/10.30629/2658-7947-2020-25-3-40-44
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