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Glomus tumor as a cause of neuropathic finger pain masquerading as neuropathy

https://doi.org/10.30629/2658-7947-2025-30-6-56-60

Abstract

   Glomus tumors (GT) are benign yet exquisitely painful neoplasms, with approximately 65 % occurring in the subungual region or fingertip. Primary manifestation is an intense neuropathic pain syndrome that is typically refractory to standard analgesic agents. A high rate of diagnostic errors (43–65 %) frequently leads to misdiagnosis, with diagnostic delays ranging from 3 to 15 years.

   The aim of this article is to present your own observations, literature data.

About the Authors

O. A. Tikhonova
Immanuel Kant Baltic Federal University
Russian Federation

Kaliningrad



E. S. Druzhinina
Pirogov Russian National Research Medical University
Russian Federation

Moscow



A. S. Karapetyan
Center for Hand Surgery and Reconstructive Microsurgery, S.S. Yudin City Clinical Hospital
Russian Federation

Moscow



D. S. Druzhinin
I.M. Sechenov First Moscow State Medical University (Sechenov University); Yaroslavl State Medical University
Russian Federation

Moscow; Yaroslavl



E. Ya. Reznik
Immanuel Kant Baltic Federal University
Russian Federation

Kaliningrad



References

1. Tang CYK, Tipoe T, Fung B. Where is the Lesion? Glomus Tumours of the Hand. Arch Plast Surg. 2013 ;40(5):492–5. doi: 10.5999/aps.2013.40.5.492

2. Santoshi J, Kori V, Khurana U. Glomus tumor of the fingertips: A frequently missed diagnosis. J Family Med Prim Care. 2019;8(3):904. doi: 10.4103/jfmpc.jfmpc_88_19

3. Kumar S, Tiwary S, More R, Kumar P, Khanna A. Digital glomus tumor: An experience of 57 cases over 20 years. J Family Med Prim Care.2020;9(7):3514. doi: 10.4103/jfmpc.jfmpc_446_20

4. Altarifi ME, Kalas A, Alnajjar A, Yasin Dali M, Alkhowailed MS. Glomus tumor: A rare differential diagnosis for subungual lesions. Radiology Case Reports. 2024;19(12):6034–8. doi: 10.1016/j.radcr.2024.08.116

5. Stepanova Yu.A., Glotov A.V., Shirokov V.S., Kovalenko A.A., Sapelkin S.V., Akhtanin E.A., Lednev A.N. Glomus angioma : series of cases and literature review. Medical Visualization. (Medicinskaja visualisacija).2024;28(1):120–140. (In Russ.) doi: 10.24835/1607-0763-1356

6. Shin D-K, Kim M-S, Kim S-W, Kim S-H. A Painful Glomus Tumor on the Pulp of the Distal Phalanx. J Korean Neurosurg Soc. 2010;48(2):185. doi: 10.3340/jkns.2010.48.2.185

7. Schiefer TK, Parker WL, Anakwenze OA, Amadio PC, Inwards CY, Spinner RJ. Extradigital Glomus Tumors: A 20-Year Experience. Mayo Clinic Proceedings. 2006;81(10):1337–44. doi: 10.4065/81.10.1337

8. Venugopal PR. Extradigital Glomus Tumor – a Rare Cause for Undiagnosed Chronic Pain in Unusal Sites. Indian J Surg. 2015;77(Suppl 3):910–2. doi: 10.1007/s12262-014-1062-1 PMID: 27011481

9. Baek HJ, Lee SJ, Cho KH, Choo HJ, Lee SM, Lee YH, Suh KJ, Moon TY, Cha JG, Yi JH, Kim MH, Jung SJ, Choi JH. Subungual tumors: clinicopathologic correlation with US and MR imaging findings. Radiographics. 2010;30(6):1621–36. doi: 10.1148/rg.306105514

10. Hazani R, Houle JM, Kasdan ML, Wilhelmi BJ. Glomus tumors of the hand. Eplasty. 2008;8:e48. PMID: 18997858; PMCID: PMC2567120

11. Bhaskaranand K, Navadgi BC. Glomus Tumour of the Hand. Journal of Hand Surgery. 2002;27(3):229–31. doi: 10.1054/jhsb.2001.0746

12. Giele H. Hildreth’s Test is a Reliable Clinical Sign for the Diagnosis of Glomus Tumours. Journal of Hand Surgery. 2002 Apr;27(2):157–8. doi: 10.1054/JHSB.2001.0724

13. Netscher DT, Aburto J, Koepplinger M. Subungual Glomus Tumor. The Journal of Hand Surgery. 2012;37(4):821–3. doi: 10.1016/j.jhsa.2011.10.026

14. Samaniego E, Crespo A, Sanz A. Key diagnostic features and treatment of subungual glomus tumor. Actas Dermosifiliogr. 2009;100(10):875–82. PMID: 20038364

15. Morey VM, Garg B, Kotwal PP. Glomus tumours of the hand : Review of literature. J Clin Orthop Trauma. 2016;7(4):286–91. doi: 10.1016/j.jcot.2016.04.006

16. Horcajadas BA, Lafuente LJ, De La Cruz Burgos R, Muñiz HS, Roca AS, Ortega GS, et al. Ultrasound and MR findings in tumor and tumor-like lesions of the fi ngers. Eur Radiol. 2003;13(4):672–85. doi: 10.1007/s00330-002-1477-0

17. Dhami A, Vale SM, Richardson ML, Schachtel AK, Fleckman P. Comparing Ultrasound with Magnetic Resonance Imaging in the Evaluation of Subungual Glomus Tumors and Subungual Myxoid Cysts. Skin Appendage Disord. 2023;9(4):262–7. doi: 10.1159/000530397 PMID: 37564693

18. Wang H, Han J, Wang Z, Zhou H, Alhaskawi A, Dong Y, Lu H. Ten Years’ Experience with Diagnosis and Treatment of Non-Subungual Glomus Tumor in the Fingers. Technol Cancer Res Treat. 2024; 23:15330338241287087. doi: 10.1177/15330338241287087

19. Vandenberghe L, De Smet L. Subungual glomus tumours: a technical tip towards diagnosis on plain radiographs. Acta Orthop Belg. 2010;76(3):396–7. PMID: 20698463

20. Al-Qattan MM, Al-Namla A, Al-Thunayan A, Al-Subhi F, El-Shayeb AF. Magnetic Resonance Imaging in the Diagnosis of Glomus Tumours of the Hand. Journal of Hand Surgery. 2005;30(5):535–40. doi: 10.1016/j.jhsb.2005.06.009

21. Mazhar FN, Nasab OM. A case report: Multiple synchronous pain full glomus tumors in adjacent fingers; a review of multiple glomus tumors. Int J Surg Case Rep. 2025; 126:110724. doi: 10.1016/j.ijscr.2024.110724

22. Saaiq M. Presentation and Management Outcome of Glomus Tumors of the Hand. Arch Bone Jt Surg. 2021;9(3):312–8. doi: 10.22038/abjs.2020.47878.2367

23. Lin Y-C, Hsiao P-F, Wu Y-H, Sun F-J, Scher RK. Recurrent Digital Glomus Tumor: Analysis of 75 Cases. Dermatologic Surgery. 2010 Sept;36(9):1396–400. doi: 10.1111/j.1524-4725.2010.01647.x

24. Folpe AL, Fanburg–Smith JC, Miettinen M, Weiss SW. Atypical and Malignant Glomus Tumors: Analysis of 52 Cases, With a Proposal for the Reclassifi cation of Glomus Tumors. The American Journal of Surgical Pathology. 2001;25(1):1–12. doi: 10.1097/00000478-200101000-00001


Review

For citations:


Tikhonova O.A., Druzhinina E.S., Karapetyan A.S., Druzhinin D.S., Reznik E.Ya. Glomus tumor as a cause of neuropathic finger pain masquerading as neuropathy. Russian neurological journal. 2025;30(6):56-60. (In Russ.) https://doi.org/10.30629/2658-7947-2025-30-6-56-60

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