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The role of neurotrophic factors during rehabilitation therapy in patients with cerebral palsy
https://doi.org/10.30629/2658-7947-2024-29-5-23-30
Abstract
Blood concentration of neurotrophic factors (NTF) in patients with cerebral palsy after the use of the “non-invasive brain-computer-exohand interface” technique demonstrated a decrease in the level of NTFs on the 10th day after rehabilitation training, which was accompanied by an improvement in motor, cognitive functions and emotional status of patients. Moreover, different NTFs demonstrated different levels of concentration changes. The literature base about influence of NTFs on the mechanisms of neuroplasticity was analyzed. The review presents the results of studies on the therapeutic targets of NTFs and their different abilities to penetrate the blood-brain barrier, which apparently explains their participation in the processes of neuroplasticity. Analysis of literature data indicates the active involvement of NTF in the mechanisms of functional restructuring and their possible role in restoring motor activity in children with cerebral palsy, positive effect on cognitive functions and emotional status.
Supporting agencies: The study was supported by the Russian Science Foundation and Republic of Crimea grant 22-15-20035. https://rscf.ru/project/22-15-20035
About the Authors
L. L. Korsunskaya
V.I. Vernadsky Crimean Federal University, Medical Institute named after S.I. Georgievsky
Russian Federation
Russian Federation
Simferopol
E. S. Ageeva
V.I. Vernadsky Crimean Federal University, Medical Institute named after S.I. Georgievsky
Russian Federation
Russian Federation
Simferopol
N. V. Larina
V.I. Vernadsky Crimean Federal University, Medical Institute named after S.I. Georgievsky
Russian Federation
Russian Federation
Simferopol
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Korsunskaya L.L., Ageeva E.S., Larina N.V. The role of neurotrophic factors during rehabilitation therapy in patients with cerebral palsy. Russian neurological journal. 2024;29(5):23-30. (In Russ.) https://doi.org/10.30629/2658-7947-2024-29-5-23-30
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