Аутоиммунный энцефалит, ассоциированный с анти-LGI-1-антителами

Аутоиммунный энцефалит, ассоциированный с антителами к богатому лейцином инактивируемому глиомой протеину 1 (LGI-1 — Leucine-rich glioma-inactivated antibody), представляет собой новый тип аутоиммунного неврологического заболевания. Приводится описание клинического случая заболевания у пациентки, первыми проявлениями заболевания у которой были когнитивные нарушения, в том числе амнестический синдром, и судорожные приступы. В крови и цереброспинальной жидкости были выявлены антитела — IgG к анти-LGI-1.
Иммунная терапия, включавшая внутривенное введение глюкокортикостероидов, иммуноглобулина, плазмаферез, привела к выраженной положительной динамике состояния пациентки. Пациентка после курса терапии вернулась к прежней работе.

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