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Cognitive status in institutionalized oldest old

https://doi.org/10.30629/2658-7947-2022-27-6-63-69

Abstract

Introduction. Oldest old are the fastest growing age group in most countries of the world, including the Russian Federation. A signifi cant part of oldest old are feel lonely, need care and live in long term care facilities (institutionalized). Disability and institutionalization are associated with an increased risk of cognitive impairment in oldest old. The cognitive status in this group has been studied insuffi ciently in Russia. Determination of diagnostic standards for cognitive functions assessment scales in oldest old is important both for clinical practice and for scientifi c research.

Objective: to evaluate cognitive functions and to determine diagnostic value for various psychological tests in persons aged ≥ 90, who live in long term care facilities (LTCF).

Material and methods. The persons aged ≥ 90 years that live in LTCF (boarding houses or nursing homes) in Moscow were examined. All patients passed neuropsychological examination, which included Mini-mental State Examination (MMSE), Frontal Assessment Battery (FAB), 5-word test, clock-drawing test and verbal fl uency tests. In addition, original questionnaire was used for cognitive impairment screening.

Results. Dementia was found in 69% of oldest old, who live in LTCF; frontal dysfunction in 89.1% and “hippocampal type” of memory disorders in 57.5%. The results of phonemic verbal fl uency test were normal in 6.7% only and of semantic verbal fl uency test in 8.1%. For diagnosis of dementia in institutionalized subjects sensitivity of MMSE ≤ 23 points was 97% and specifi city was 90.9%. For the FAB optimal sensitivity/specifi city ratio (98/83.7%) was at score of ≤ 14. The clock-drawing test sensitivity for dementia was 91.9% and specifi city was 69.7% at total score ≤ 6 .

Conclusion. Institutionalized persons aged ≥ 90 years have a high prevalence of dementia. The above mentioned tests can be used for oldest old examination. Further studies of the relationship of cognitive impairment with other geriatric disorders in oldest old are needed.

About the Authors

R. I. Isaev
Pirogov Russian National Research Medical University, Gerontology Research and Clinical Centre
Russian Federation

Moscow



E. A. Mkhitaryan
Pirogov Russian National Research Medical University, Gerontology Research and Clinical Centre
Russian Federation

Moscow



I. D. Strazhesko
Pirogov Russian National Research Medical University, Gerontology Research and Clinical Centre
Russian Federation

Moscow



N. M. Vorobyeva
Pirogov Russian National Research Medical University, Gerontology Research and Clinical Centre
Russian Federation

Moscow



V. S. Ostapenko
Pirogov Russian National Research Medical University, Gerontology Research and Clinical Centre
Russian Federation

Moscow



O. N. Tkacheva
Pirogov Russian National Research Medical University, Gerontology Research and Clinical Centre
Russian Federation

Moscow



N. N. Yakhno
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Moscow



References

1. United Nations Department of Economic and Social Aff airs, Population Division (2020). World Population Ageing 2020 Highlights: Living arrangements of older persons (ST/ESA/ SER.A/451).

2. United Nations, Department of Economic and Social Aff airs, Population Division, Population Estimates and Projections Section. World Population Prospects, the 2019 Revision. Probabilistic Population Projections based on the World Population Prospects 2019. Total population (both sexes combined) by fi ve-year age group, region, subregion and country, 2020–2100. Median (50 percent) prediction interval, 2020–2100. https://population.un.org/wpp/Download/Probabilistic/Population/

3. Bulletin «Population of the Russian Federation by gender and age as of January 1, 2010». (In Russ.). https://gks.ru/bgd/regl/B10_111/Main.htm

4. Bulletin «Population of the Russian Federation by gender and age as of January 1, 2020». (In Russ.). https://gks.ru/bgd/regl/b20_111/Main.htm

5. Gibson D., Goss J. Ninety and not out-Understanding our oldest old. Australas J Ageing. 2020;39(1):e62–e69. https://doi.org/10.1111/ajag.12695

6. Kawas C.H. The oldest old and the 90+ Study. Alzheimers Dement. 2008;4(1 Suppl 1):S56–9. https://doi.org/10.1016/j.jalz.2007.11.007

7. Yang Z., Slavin M.J., Sachdev P.S. Dementia in the oldest old. Nat Rev Neurol. 2013;9(7):382–93. https://doi.org/10.1038/nrneurol.2013.105

8. Bullain S.S., Corrada M.M. Dementia in the oldest old. Continuum (Minneap Minn). 2013;19(2Dementia):457–69. https://doi.org/10.1212/01.CON.0000429172.27815.3f

9. Brookmeyer R., Johnson E., Ziegler-Graham K., Arrighi H.M. Forecasting the global burden of Alzheimer’s disease. Alzheimers Dement. 2007;3:186–91. https://doi.org/10.1016/j.jalz.2007.04.381

10. World Health Organization. World report on Ageing and Health. 2015. Available from: http://apps.who.int/iris/bitstream/10665/186463/1/9789240694811_eng.pdf?ua=1

11. Gerritsen L., Wang H.X., Reynolds C.A., Fratiglioni L., Gatz M., Pedersen N.L. Infl uence of Negative Life Events and Widowhood on Risk for Dementia. Am J Geriatr Psychiatry. 2017;25(7):766– 778. https://doi.org/10.1016/j.jagp.2017.02.009

12. Zaharov V.V., Voznesenskaуa T.G. Neuro-psychiatric disorders: diagnostic tests. M.: MEDpressinform, 2013:315 р. (In Russ.).

13. Shin S.H., Kim G., Park S. Widowhood Status as a Risk Factor for Cognitive Decline among Older Adults. Am J Geriatr Psychiatry. 2018;26(7):778–787. https://doi.org/10.1016/j.jagp.2018.03.013

14. Arosio B., Ostan R., Mari D., Damanti S., Ronchetti F., Arcudi S. et al. Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically diffi cult to assess. Mech Ageing Dev. 2017;165(Pt B):185–194. https://doi.org/10.1016/j.mad.2017.02.010

15. Selbaek G., Kirkevold Ø., Engedal K. The prevalence of psychiatric symptoms and behavioural disturbances and the use of psychotropic drugs in Norwegian nursing homes. Int J Geriatr Psychiatry. 2007;22(9):843–9. https://doi.org/10.1002/gps.1749. PMID: 17193341

16. Harada C.N., Natelson Love M.C., Triebel K.L. Normal cognitive aging. Clin Geriatr Med. 2013;29(4):737–752. https://doi.org/10.1016/j.cge

17. Blazer D.G., Yaff e K., Karlawish J. Cognitive aging: a report from the Institute of Medicine. JAMA. 2015;313(21):2121–2. https://doi.org/10.1001/jama.2015.4380

18. Slavin M.J., Brodaty H., Sachdev P.S. Challenges of diagnosing dementia in the oldest old population. J Gerontol A Biol Sci Med Sci. 2013;68(9):1103–11. https://doi.org/10.1093/gerona/glt051

19. Inagaki H., Gondo Y., Hirose N., Masui Y., Kitagawa K., Arai Y. et al. Cognitive function in Japanese centenarians according to the Mini-Mental State Examination. Dement Geriatr Cogn Disord. 2009;28(1):6–12. https://doi.org/10.1159/000228713

20. Brodaty H., Woolf C., Andersen S., ICC-dementia et al. (International Centenarian Consortium — dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol. 2016;16:52. https://doi.org/10.1186/s12883-016-0569-4

21. Heeren T.J., Lagaay A.M., von Beek W.C., Rooymans H.G., Hijmans W. Reference values for the Mini-Mental State Examination (MMSE) in octo- and nonagenarians. J Am Geriatr Soc. 1990;38(10):1093–6. https://doi.org/10.1111/j.1532-5415.1990.tb01371.x

22. Kahle-Wrobleski K., Corrada M.M., Li B., Kawas C.H. Sensitivity and specifi city of the mini-mental state examination for identifying dementia in the oldest-old: the 90 + study. J Am Geriatr Soc. 2007;55(2):284–289. https://doi.org/10.1111/j.1532-5415.2007.01049.x

23. Iavarone A., Lorè E., De Falco C., Milan G., Mosca R., Pappatà S. et al.Dysexecutive performance of healthy oldest old subjects on the Frontal Assessment Battery. Aging Clin Exp Res. 2011;23(5– 6):351–6. https://doi.org/10.1007/BF03337760


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For citations:


Isaev R.I., Mkhitaryan E.A., Strazhesko I.D., Vorobyeva N.M., Ostapenko V.S., Tkacheva O.N., Yakhno N.N. Cognitive status in institutionalized oldest old. Russian neurological journal. 2022;27(6):63-69. (In Russ.) https://doi.org/10.30629/2658-7947-2022-27-6-63-69

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ISSN 2658-7947 (Print)
ISSN 2686-7192 (Online)