Показатели системы цитокинов и неоангиогенеза в крови при острой дискогенной пояснично-крестцовой радикулопатии у пациентов молодого возраста

Введение. Патогенез дискогенной пояснично-крестцовой боли у лиц молодого возраста является сложным и многокомпонентным. Данные по содержанию цитокинов и факторов неоангиогенеза при острой дискогенной пояснично-крестцовой радикулопатии немногочисленны и зачастую противоречивы.

Цель исследования: оценить показатели системы цитокинов и неоангиогенеза в крови при острой дискогенной пояснично-крестцовой радикулопатии у пациентов молодого возраста.

Материал и методы. В исследовании приняли участие 49 пациентов (27 (55,1%) мужчин и 22 (44,9%) женщины) в возрасте 36 [27; 45] лет с острой пояснично-крестцовой болью, обусловленной дегенеративными изменениями позвоночника и компрессией спинномозговых нервов по данным МРТ. Группу контроля составили 17 здоровых лиц (10 (58,8%) мужчин и 7 (41,2%) женщин) в возрасте 33 [25; 41] лет. Уровень C-реактивного белка измеряли на автоматическом биохимическом анализаторе Konelab 30Iprime (ThermoFisher, Финляндия). Уровни интерлейкина-1β (ИЛ-1β), интерлейкина-6 (ИЛ-6), интерлейкина-8 (ИЛ-8), фактора некроза опухоли альфа (ФНО-α), фактора роста эндотелия cосудов А (ФРЭС-А) в крови определяли твердофазным иммуноферментным методом (ELISA) на плашечном ИФА-анализаторе Реал-бест (Россия) с использованием наборов реагентов Cloud-Clone Corp. (США, Китай).

Результаты. У пациентов молодого возраста с острой дискогенной пояснично-крестцовой радикулопатией по сравнению с контрольной группой выявлено повышение уровней С-реактивного белка (11,2 [7,1; 15,3] против 4,2 [3,5; 4,9] мг/мл; р = 0,011), ФНО-α (23,1 [16,8; 29,5] против 9,7 [6,9; 12,5] пг/мл; р = 0,001), ИЛ-1β (4,7 [3,1; 6,3] против 3,2 [2,3;4,1] пг/мл; р = 0,041), ИЛ-6 (11,2 [6,1; 16,3] против 4,5 [3,1; 5,9] пг/мл; р = 0,007), ИЛ-8 (30,3 [21,9; 48,8] против 20,5 [8,5; 32,6] пг/мл; р = 0,023) и ФРЭС-А (318 [260; 570] против 168 [100; 240] пг/мл; р = 0,002).

Заключение. Полученные результаты подтверждают значение провоспалительных факторов и показателей неоангиогенеза в развитии острой дискогенной пояснично-крестцовой радикулопатии у пациентов молодого возраста.

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