Serologic markers of Еpstein-Вarr virus infection in patients with pediatric multiple sclerosis
Abstract
Epstein–Barr virus (EBV) infection is considered as risk factor for multiple sclerosis (MS) and possibly a factor in the adverse course of the disease. Forty-three patients with remitting MS in remission with the onset of the disease before the age of 18 years and 49 volunteers without MS participated in the study. It was found that the majority of patients with MS, as well as the majority of the control were seropositive for EBV infection (100% and 91.8%, respectively, р = 0.120). All identified seropositive patterns are typical of EBV past-infection. The combination of anti-VCA IgG and anti-EBNA-1 IgG is more common in patients with MS (97.7% vs. 83.7% in control, p = 0.034). The anti-VCA IgG level above the median and the seropositive result for anti-EBNA-1 IgG are associated with MS (OR 5.29; 95СI 1.99–14.04; p < 0.001 and OR 15.36; 95СI 1.95–20.70; p = 0.009, respectively). Anti-VCA IgG levels above the median are associated with HLA-DRB1*1501 in patients with MS (OR 8.4; 95CI 0.87–80.92; p = 0.047). Anti-VCA IgG level, anti-EBNA-1 IgG are not correlated with the age of the MS onset, disability, frequency of exacerbations, as well as with serum concentrations of 25-hydroxy vitamin D. It can be assumed that the patients with remitting MS have features of the EBV past-infection immune status. Dynamic observation of the serological markers levels of EBV infection is important not only in remission, but also in exacerbation of MS. The results of these observations will assess the prospects of EBV infection control and treatment for the management of patients with MS.
About the Authors
I. V. Smagina
Altai state medical University
Russian Federation
Russian Federation
Barnaul, 656038.
E. Yu. Elchaninova
Altai state medical University
Russian Federation
Russian Federation
Barnaul, 656038.
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Smagina I.V., Elchaninova E.Yu. Serologic markers of Еpstein-Вarr virus infection in patients with pediatric multiple sclerosis. Russian neurological journal. 2019;24(5):38-45. (In Russ.)
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