Difficulties in diagnosing atypical variants of Alzheimer’s disease
https://doi.org/10.30629/2658-7947-2021-26-5-16-23
Abstract
Alzheimer’s disease (AD) is the most common cause of dementia in the population. Late onset AD has a classic clinical picture with short-term memory deficit, apraxia and agnosia. Patients with early-onset AD may have an atypical clinical picture which complicates diagnosis. Atypical AD variants include the logopenic variant of primary progressive aphasia, posterior cortical atrophy, behavioral, biparietal, and cortico-basal variants. These variants have pathomorphological signs similar to classical AD, but at an early stage they are characterized by focal atrophy which explains their clinical polymorphism. This article provides a review of the current literature on atypical types of AD and presents a clinical case of a 62-year-old patient in whom the disease debuted with prosopagnosia due to focal atrophy of the temporo-occipital regions of the non-dominant hemisphere.
About the Authors
A. A. Tappakhov
M.K. Ammosov North-Eastern Federal University;
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Yakutsk
T. Ya. Nikolaeva
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Yakutsk
T. E. Popova
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Yakutsk
N. A. Shnayder
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology;
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Saint Petersburg; Krasnoyarsk
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For citations:
Tappakhov A.A., Nikolaeva T.Ya., Popova T.E., Shnayder N.A. Difficulties in diagnosing atypical variants of Alzheimer’s disease. Russian neurological journal. 2021;26(5):16-23. (In Russ.) https://doi.org/10.30629/2658-7947-2021-26-5-16-23
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