Пятилетний опыт применения нового класса препаратов для таргетной профилактической терапии мигрени
https://doi.org/10.30629/2658-7947-2021-26-3-4-14
Аннотация
Статья посвящена новому классу антимигренозных препаратов — моноклональным антителам (мАТ), нарушающим передачу сигнала кальцитонин-ген родственного пептида (КГРП). Кратко рассматриваются биологические эффекты КГРП в периферической и центральной нервной системе и его роль в патогенезе мигрени. Анализируются данные систематических обзоров рандомизированных клинических исследований эффективности и безопасности мАТ к КГРП (фреманезумаб, эптинезумаб и галканезумаб) и его рецептору (эренумаб) при эпизодической и хронической мигрени. Обсуждаются результаты пятилетнего применения эренумаба в рамках клинических исследований и реальной практики.
Об авторах
А. В. Амелин
ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава России
Россия
Россия
Санкт-Петербург
А. Ю. Соколов
ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава России; ФГБУН «Институт физиологии им. И.П. Павлова» Российской академии наук
Россия
Россия
Санкт-Петербург
Ю. С. Ваганова
ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава России
Россия
Россия
Санкт-Петербург
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Рецензия
Для цитирования:
Амелин А.В., Соколов А.Ю., Ваганова Ю.С. Пятилетний опыт применения нового класса препаратов для таргетной профилактической терапии мигрени. Российский неврологический журнал. 2021;26(3):4-14. https://doi.org/10.30629/2658-7947-2021-26-3-4-14
For citation:
Amelin A.V., Sokolov A.Yu., Vaganova Yu.S. Five-year experience of using a new class of drugs for targeted preventive therapy of migraine. Russian neurological journal. 2021;26(3):4-14. (In Russ.) https://doi.org/10.30629/2658-7947-2021-26-3-4-14
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