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Pathogenetic and diagnostic significance of serotonin levels in platelets in children with epileptic and non-epileptic paroxisms
https://doi.org/10.30629/2658-7947-2025-30-5-46-52
Abstract
Justification. The content of serotonin in blood platelets has not been studied in children with various paroxysmal disorders of consciousness.
The aim of the study was to study of serotonin metabolism in the structures of the brain in children with epilepsy.
Material and methods. The study involved 106 children up to 4.5 years with paroxysmal disorders of consciousness, 88 their mothers, 113 healthy children and 15 their mothers.
Were studied the data of the content of serotonin in blood platelets and cerebrospinal fluid, also data of anamnesis, clinical and instrumental examination. The indicators of serotonin contained in blood platelets and cerebrospinal fluid were determined based on a modified fluorometric method. The methods used in the mathematical and statistical processing included the parametric Student t-test, as well as the χ2-distribution and Fisher's F-distribution.
Results. In healthy newborns the levels of serotonin contained in blood platelets were significantly higher compared to it levels in children older than 1 months. In children with epilepsy the levels of serotonin are significantly higher than in children with non-epileptic paroxysms older than 1 month. The levels of serotonin contained in the cerebrospinal fluid of children with epilepsy correlate with high levels of serotonin contained in blood platelets.
Conclusion. The data of the content of serotonin in children with epilepsy, healthy children and their mothers indicate the advisability of their direct use for the differential diagnosis in young children with paroxysmal conditions. The content of serotonin in the cerebrospinal fluid of children with epilepsy is significantly higher than its content in the cerebrospinal fluid of healthy adults.
About the Authors
V. I. Guzeva
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
St. Petersburg.
O. V. Guzeva
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
St. Petersburg.
V. V. Guzeva
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
St. Petersburg.
M. A. Razumovskii
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
St. Petersburg.
References
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Review
For citations:
Guzeva V.I., Guzeva O.V., Guzeva V.V., Razumovskii M.A. Pathogenetic and diagnostic significance of serotonin levels in platelets in children with epileptic and non-epileptic paroxisms. Russian neurological journal. 2025;30(5):46-52. (In Russ.) https://doi.org/10.30629/2658-7947-2025-30-5-46-52
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