r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2020-25-3-40-44r-n-j-86Research ArticleИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL RESEARCHES AND CASE REPORTSСовременный взгляд на серотониновую теорию депрессииSerotonin Theory of Depression: Modern Viewhttps://orcid.org/0000-0002-0941-2242КовальзонВ. М.KovalzonV. M.

Москва

Moscow

kovalzon@sevin.ruФГБУН институт проблем экологии и эволюции им. А.Н. Северцова РАНРоссияSevertsov Institute of Ecology and Evolution of the Russian Academy of SciencesRussian Federation2020140820202534044Copyright © Ковальзон В.М., 20202020Ковальзон В.М.Kovalzon V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/86

«Серотониновая» гипотеза, выдвинутая И.П. Лапиным и Г.Ф. Оксенкругом в 1969 г., предполагает, что формирование эндогенной депрессии обусловлено сочетанием двух факторов: сниженным «базальным» уровнем мозгового серотонина и чрезмерно длительными предутренними периодами сна с быстрыми движениями глаз, во время которых выброс мозгового серотонина прекращается вовсе. В качестве средства лечения депрессии предлагается не депривация, а дробление этой фазы сна, что значительно легче переносится больными.

In development of the «serotonin» hypothesis of depression put forward by I.P. Lapin and G.F. Oxenkrug in 1969, the combination of the two factors is proposed which are responsible for depression formation: reduced “basal” 5-HT cerebral level and excessive duration of early morning REM sleep periods during which the release of cerebral serotonin ceases altogether. As a means of prevention and treatment, not the deprivation, but rather fragmentation of REM sleep is proposed, which is much easier for patients to tolerate.

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The authors declare that there are no conflicts of interest present.