r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2026-31-3-43-50r-n-j-855Research ArticleИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL RESEARCHES AND CASE REPORTSОценка устойчивости к гипоксии пациентов с болезнью ПаркинсонаAssessment of hypoxia resistance in patients with Parkinson’s diseasehttps://orcid.org/0000-0001-8659-9832ГусеваО. В.GusevaO. V.

Томск

Tomsk

guseva.ov@ssmu.ruhttps://orcid.org/0000-0001-6547-6622ЖуковаН. Г.ZhukovaN. G.

Томск

Tomsk

Сибирский государственный медицинский университетРоссияSiberian State Medical UniversityRussian Federation2026310820263134350Copyright © Гусева О.В., Жукова Н.Г., 20262026Гусева О.В., Жукова Н.Г.Guseva O.V., Zhukova N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/855

Цель исследования — оценка устойчивости к гипоксии при болезни Паркинсона (БП), связь с демографическими факторами, тяжестью заболевания, физическим и функциональным состоянием.Материал и методы. В исследование включено 263 пациента с БП и 145 человек контрольной группы (КГ). Пациентам проводили оценку пробы Штанге для определения устойчивости к гипоксии, двигательной функции по шкале (MDS UPDRS) — часть III, силы кисти, теста «6-минутной ходьбы» (ТШХ), когнитивного статуса по шкале MOCA.Результаты. У пациентов с БП и в КГ устойчивость к гипоксии мужчин была больше, чем женщин, при этом показатели мужчин с БП и КГ не различались. Устойчивость к гипоксии пациенток с БП была меньше, чем в КГ и снижалась при повышении тяжести БП. Не получено связи устойчивости к гипоксии и возраста при БП и в КГ. Устойчивость к гипоксии женщин с БП была связана с силой кисти, ТШХ и показателем MOCA; у мужчин с БП — с силой кисти и показателем MOCA. У мужчин и женщин КГ подобных корреляций не получено.Заключение: установлена гендерная зависимость устойчивости к гипоксии — снижение у женщин с БП и КГ, больше выраженное при БП, обусловленное тяжестью заболевания, снижением физического и функционального статуса. Связь устойчивости к гипоксии с физическими и когнитивными характеристиками предопределяют выбор направления тренировок для коррекции сниженной устойчивости к гипоксии при БП.

The aim of the study — an assessment of resistance to hypoxia in Parkinson’s disease (PD), relationship with demographic factors, severity of the disease, physical and functional state.Material and methods. The study included 263 patients with PD and 145 people in the control group (CG). Patients were assessed with Barge test to determine resistance to hypoxia, motor function of PD on the scale (MDS UPDRS) — part III, grip strength, the “6-minute walk” test, cognitive status on the MOCA scale.Results. In PD and in CG, men’s resistance to hypoxia was greater than that of women, while the indicators of men with PD and CG did not differ. The resistance to hypoxia in women with PD was less than KG and decreased with increasing severity of PD. The relationship of resistance to hypoxia in PD and CG with age has not been obtained. The resistance to hypoxia of women with PD was correlated with grip strength, “6-minute walk” test and the result of MOCA, while men’s strength was correlated with hand strength, which did not differ from CG, and the result of MOCA. No correlations were found of men and women in CG.Conclusion. Gender dependence of resistance to hypoxia has been established: the decrease in women with PD and in CG which is more pronounced in PD, due to decrease in physical and functional status. The interrelationships with the physical and cognitive levels determine the choice of training direction to correct the reduced resistance to hypoxia in PD.

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The authors declare that there are no conflicts of interest present.