r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2026-31-3-27-34r-n-j-853Research ArticleИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL RESEARCHES AND CASE REPORTSОсмотический демиелинизирующий синдромOsmotic demyelinating syndromehttps://orcid.org/0000-0002-4084-3307РаевскаяА. И.RaevskayaA. I.

Ставрополь

Stavropol

nastya_raevskaya96@mail.ruhttps://orcid.org/0009-0001-9907-5912КовалеваО. Д.KovalevaO. D.

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Stavropol

olg.kovalyova2010@yandex.ruhttps://orcid.org/0009-0000-0335-1488ЗинченкоД. А.ZinchenkoD. A.

Ставрополь

Stavropol

Daniel.Zz@yandex.ruhttps://orcid.org/0009-0006-6798-8721БоюнсузоваЗ. Р.BoyunsuzovaZ. R.

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Stavropol

zuhra1094@mail.ruhttps://orcid.org/0000-0001-9187-8481ВышловаИ. А.VyshlovaI. A.

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Stavropol

irisha2801@yandex.ruhttps://orcid.org/0000-0003-1472-6024КарповС. М.KarpovS. M.

Ставрополь

Stavropol

karpov25@rambler.ruСтавропольский государственный медицинский университетРоссияStavropol State Medical UniversityRussian FederationСтавропольская краевая клиническая больницаРоссияStavropol Regional Clinical HospitalRussian Federation2026310820263132734Copyright © Раевская А.И., Ковалева О.Д., Зинченко Д.А., Боюнсузова З.Р., Вышлова И.А., Карпов С.М., 20262026Раевская А.И., Ковалева О.Д., Зинченко Д.А., Боюнсузова З.Р., Вышлова И.А., Карпов С.М.Raevskaya A.I., Kovaleva O.D., Zinchenko D.A., Boyunsuzova Z.R., Vyshlova I.A., Karpov S.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/853

Осмотический демиелинизирующий синдром (ОДС) — редкое заболевание, возникающее при быстром изменении осмотического давления крови и приводящее к серьезным неврологическим расстройствам.Материал и методы. Проведен обзор литературных источников на русском и английском языках за период 2015–2025 гг., использованы базы данных РИНЦ, PubMed. Представлено клиническое наблюдение пациентки с ОДС.Результаты. В представленном случае ОДС проведение нейровизуалиационных исследований позволило подтвердить центральный понтинный и экстрапонтинный миелинолиз. Лабораторные анализы позволили своевременно выявить развитие тяжёлого полиорганного поражения. Применение комплексного терапевтического подхода с учётом всех аспектов клинической картины привело к стабилизации состояния пациента.Заключение. Представленный клинический случай подчеркивает сложность дифференциальной диагностики ОДС и необходимость комплексной оценки состояния пациента, включающей дополнительные методы обследования. Междисциплинарное взаимодействие обеспечивает адекватное управление заболеванием и улучшение результатов лечения.

Osmotic demyelinating syndrome (ODS) is a rare disorder that occurs when the osmotic pressure of the blood changes rapidly and leads to serious neurological disorders.Purpose: to conduct a review of literary sources of domestic and foreign authors examining ODS, and also to describe it using the example of our own clinical observation.Material and methods. A review of literary sources in Russian and English for the period 2015–2025 was conducted, using the RSCI and PubMed databases. A clinical case of a patient with ODS is presented.Results. A clinical case of osmotic demyelination syndrome is presented. Modern neuroimaging studies confi rmed central pontine and extrapontine myelinolysis. Neuroimaging and laboratory tests enabled the timely detection of severe multiorgan damage. This case highlights the need for timely diagnosis and a multidisciplinary approach to the management of this pathology. Conclusion. This clinical case highlights the complexity of diff erential diagnosis and the need for a comprehensive assessment of the patient’s condition, including additional diagnostic methods. The importance of interdisciplinary collaboration is evident, ensuring adequate disease management and improving treatment outcomes.

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The authors declare that there are no conflicts of interest present.