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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">r-n-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский неврологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian neurological journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2658-7947</issn><issn pub-type="epub">2686-7192</issn><publisher><publisher-name>МИА</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/2658-79472025-30-5-40-45</article-id><article-id custom-type="elpub" pub-id-type="custom">r-n-j-758</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL RESEARCHES AND CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Головная боль у пациентов с рассеянным склерозом: коморбидные эмоциональные и диссомнические нарушения</article-title><trans-title-group xml:lang="en"><trans-title>Headache and multiple sclerosis: comorbid emotional and insomnia disorders</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4084-3307</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Раевская</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Raevskaya</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ставрополь.</p></bio><bio xml:lang="en"><p>Stavropol.</p></bio><email xlink:type="simple">nastya_raevskaya96@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9187-8481</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вышлова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vyshlova</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ставрополь.</p></bio><bio xml:lang="en"><p>Stavropol.</p></bio><email xlink:type="simple">irisha2801@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-8181-9607</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткаченко</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachenko</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ставрополь.</p></bio><bio xml:lang="en"><p>Stavropol.</p></bio><email xlink:type="simple">nickypack@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-8779-3478</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конарева</surname><given-names>Я. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Konareva</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ставрополь.</p></bio><bio xml:lang="en"><p>Stavropol.</p></bio><email xlink:type="simple">yakonareva2610@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-1618-4197</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лычагин</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lychagin</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ставрополь.</p></bio><bio xml:lang="en"><p>Stavropol.</p></bio><email xlink:type="simple">dimyan.boxing@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-2535-9458</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кочкаров</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kochkarov</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ставрополь.</p></bio><bio xml:lang="en"><p>Stavropol.</p></bio><email xlink:type="simple">kochckarov.nf@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1472-6024</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпов</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpov</surname><given-names>S. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ставрополь.</p></bio><bio xml:lang="en"><p>Stavropol.</p></bio><email xlink:type="simple">karpov25@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Ставропольский государственный медицинский университет<country>Россия</country></aff><aff xml:lang="en">Stavropol State Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2025</year></pub-date><volume>30</volume><issue>5</issue><fpage>40</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Раевская А.И., Вышлова И.А., Ткаченко Н.М., Конарева Я.В., Лычагин Д.В., Кочкаров Н.Н., Карпов С.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Раевская А.И., Вышлова И.А., Ткаченко Н.М., Конарева Я.В., Лычагин Д.В., Кочкаров Н.Н., Карпов С.М.</copyright-holder><copyright-holder xml:lang="en">Raevskaya A.I., Vyshlova I.A., Tkachenko N.M., Konareva I.V., Lychagin D.V., Kochkarov N.N., Karpov S.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.r-n-j.com/jour/article/view/758">https://www.r-n-j.com/jour/article/view/758</self-uri><abstract><p>Головная боль (ГБ) распространена среди пациентов с рам сеянным склерозом (РС), однако ее связь с другими сопутствующими расстройствами, такими как депрессия, иинсомния, остается недостаточно изученной. Цель исследования. Оценить частоту встречаемости ГБ у пациентов с РС, а также исследовать частоту и выраженность эмоциональных нарушений (депрессии, тревожности) и нарушений сна у пациентов с РС. Материал и методы. В исследование включено 60 пациентов, которые были разделены на 3 группы по 20 человек в каждой. Первую группу составили пациенты с РС, предъявляющие жалобы на ГБ, вторая группа (группа сравнения) — пациенты без ГБ. Контрольную группу составили 20 пациентов с первичными ГБ (головная боль напряжения и мигрень). Для оценки интенсивности головной боли использовалась числовая рейтинговая шкала (ЧРШ) боли. Эмоциональные нарушения оценивали по шкале депрессии Бэка и шкале тревоги Спилбергера–Ханина, выраженность нарушений сна по Питтсбургскому опроснику индекса качества сна. Статистический анализ проводился методами описательной статистики. Количественные показатели, выборочное распределение которых соответствовало нормальному, описывались с помощью средних арифметических величин (M) и стандартных отклонений (SD). Сравнение процентных долей при анализе многопольных таблиц сопряженности выполнялось с помощью критерия хи-квадрат Пирсона. Различия считались статистически значимыми при p &lt; 0,05.</p><sec><title>Результаты</title><p>Результаты. Средний показатель выраженности ГБ согласно цифровой рейтинговой шкале боли составил 5,42 ± 1,34 баллов (первая группа — 5,75 ± 1,33, контрольная группа — 5,10 ± 1,29, p = 0,126), что соответствует умеренной выраженности цефалалгии. Установлено, что наличие ГБ связано с повышенным уровнем депрессии и тревоги, а также с увеличением числа в случае инсомнии. Отмечены статистически значимые различия выраженности депрессии между первой и контрольной группами (p &lt; 0,001), причем большее число пациентов с РС и сопутствующей ГБ испытывают депрессию, а также чаще проявляют высокий уровень ситуационной и личностной тревожности. Интенсивность ГБ коррелирует с выраженностью ситуационной и личностной тревоги. Проблемы со сном чаще встречаются у пациентов с РС с ГБ, при этом нарушения сна увеличиваются с ростом неврологического дефицита.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные данные свидетельствуют о необходимости комплексного подхода к лечению пациентов с РС, включающего оценку и коррекцию не только основных неврологических нарушений, но и сопутствующих эмоциональных расстройств и нарушений сна. ГБ может рассматриваться как индикатор общего состояния пациента и потенциального риска развития изученных коморбидных состояний при РС.</p></sec></abstract><trans-abstract xml:lang="en"><p>Multiple sclerosis (MS) is often accompanied by various neurological disorders, including headache, which is common among patients with MS, but its relationship with other comorbid conditions such as depression and insomnia remains poorly understood.</p><sec><title>The aim</title><p>The aim. To assess the incidence of headache in patients with MS, and to examine the incidence and severity of emotional disorders (depression, anxiety) and insomnia in patients with MS.</p></sec><sec><title>Material and methods</title><p>Material and methods. The study included 60 patients who were divided into 3 groups of 20 people each. The fi rst group consisted of patients with MS complaining of headache, the second group (comparison group) consisted of patients with multiple sclerosis without headache. The control group consisted of 20 patients with primary headache (tension headache and migraine). A numerical pain rating scale was used to assess headache intensity. Emotional disorders were assessed using the Beck Depression Inventory and the Spielberger–Hanin Anxiety Scale, and the severity of sleep disorders was assessed using the Pittsburgh Sleep Quality Index Questionnaire. Descriptive statistics methods were used for statistical analysis. Quantitative indicators with a normal sample distribution were described using arithmetic means (M) and standard deviations (SD). Comparison of percentages in the analysis of multifield contingency tables was performed using the Pearson chi-square test. Differences were considered statistically significant at p &lt; 0.05.</p></sec><sec><title>Results</title><p>Results. The average severity of headache according to the digital pain rating scale was 5.42 ± 1.34 points (the fi rst group — 5.75 ± 1.33, the control group — 5.10 ± 1.29, p = 0.126), which corresponds to moderate severity of cephalalgia. It was found that the presence of headache is associated with an increased level of depression and anxiety, as well as with an increase in the number of cases of insomnia. Statistically significant differences in the severity of depression between the first and control groups were noted (p &lt; 0.001), with a greater number of patients with MS and concomitant headache experiencing depression, and also more often demonstrating a high level of situational and personal anxiety. The intensity of headache correlates with the severity of situational and personal anxiety. Sleep problems are more common in patients with MS with headache, while sleep disorders increase with the growth of neurological deficit.</p></sec><sec><title>Conclusion</title><p>Conclusion. The obtained data indicate the need for a comprehensive approach to the treatment of patients with MS, including assessment and correction of not only the main neurological symptoms, but also concomitant emotional and insomnia disorders. Headache may be considered as an important indicator of the patient's general condition and the potential risk of developing the studied comorbid conditions.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рассеянный склероз</kwd><kwd>головная боль</kwd><kwd>тревожность</kwd><kwd>депрессия</kwd><kwd>диссомния</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multiple sclerosis</kwd><kwd>headache</kwd><kwd>anxiety</kwd><kwd>depression</kwd><kwd>insomnia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Киселев Д.В., Спирин Н.Н., Баранова Н.С., Карпова М.С., Грись М.С. 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