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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">r-n-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский неврологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian neurological journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2658-7947</issn><issn pub-type="epub">2686-7192</issn><publisher><publisher-name>МИА</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/2658-7947-2024-29-5-46-54</article-id><article-id custom-type="elpub" pub-id-type="custom">r-n-j-622</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL RESEARCHES AND CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Роль определения деформации миокарда левого предсердия в комплексной диагностике кардиоэмболического инсульта</article-title><trans-title-group xml:lang="en"><trans-title>The role of left atrial myocardial deformation assessment in the comprehensive diagnosis of cardioembolic stroke</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9669-9164</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хамидова</surname><given-names>Л. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Khamidova</surname><given-names>L. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6973-4430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыбалко</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rybalko</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9738-1801</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванников</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivannikov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-3850-2683</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баширова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bashirova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">dr.bashirova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6824-4114</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рамазанов</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Ramazanov</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НИИ скорой помощи им. Н.В. Склифосовского<country>Россия</country></aff><aff xml:lang="en">Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>07</day><month>01</month><year>2025</year></pub-date><volume>29</volume><issue>5</issue><fpage>46</fpage><lpage>54</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хамидова Л.Т., Рыбалко Н.В., Иванников А.А., Баширова Е.А., Рамазанов Г.Р., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Хамидова Л.Т., Рыбалко Н.В., Иванников А.А., Баширова Е.А., Рамазанов Г.Р.</copyright-holder><copyright-holder xml:lang="en">Khamidova L.T., Rybalko N.V., Ivannikov A.A., Bashirova E.A., Ramazanov G.R.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.r-n-j.com/jour/article/view/622">https://www.r-n-j.com/jour/article/view/622</self-uri><abstract><sec><title>Введение</title><p>Введение. Одним из новых методов оценки предсердной кардиомиопатии (ПКМ) является спекл-трекинг эхокардиография, позволяющая провести неинвазивную диагностику дисфункции левого предсердия (ЛП).</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Определение диагностической роли деформации миокарда ЛП в развитии кардиоэмболического инсульта (КЭИ).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включено 150 пациентов в остром периоде ишемического инсульта (ИИ). Пациенты разделены на 2 группы: группу I составили 30 пациентов с КЭИ, II — 120 человек с другими этиопатогенетическими типами ИИ. Всем пациентам выполнена трансторакальная ЭхоКГ с оценкой деформации миокарда левых камер сердца.</p></sec><sec><title>Результаты</title><p>Результаты. Значения диаметра, объема и индексированного объема ЛП в группе I были больше и составили 39 [36,3; 41] мм, 65,5 [55,8; 77,5] мл и 37 [25,8; 44,8] мл/м2 , соответственно. Показатели деформации миокарда ЛП у пациентов группы I выходили за пределы нормальных значений и статистически значимо отличались, составив 14,1 [22; 5,25]%, −10 [−11,5; −5,25]% и −4,25 [−10,4; 0,575]% для показателей деформации в фазу резервуара (ЛПСрКД), проводника (ЛПСпрКД) и сокращения (ЛПСскрКД), соответственно. При проведении многофакторного регрессионного анализа с поправками на конфаудеры, статистически значимыми показателями оставались ЛПСпрКД и ЛПСскрКД. Так, каждое последующее увеличение показателя ЛПСпрКД на 1% увеличивало шансы КЭИ в 1,151 раза (ОШ: 1,151, 95% ДИ: 1,043–1,271, p = 0,006), каждое последующее увеличение показателя ЛПСскрКД на 1% — в 1,11 раза (ОШ: 1,102, 95% ДИ: 1,032–1,178, p = 0,004). Для определения оптимального диагностического порога и диагностической эффективности анализа деформации в отношении КЭИ проведен ROC-анализ.</p></sec><sec><title>Заключение</title><p>Заключение. В группе I регистрировали статистически значимо более высокие значения размеров и объемов ЛП, а показатели деформации ЛП статистически значимо отличались от показателей II группы и выходили за пределы нормы. Установлено, что статистически значимыми показателями деформации миокарда ЛП, позволяющими диагностировать КЭИ, были ЛПСпрКД и ЛПСскрКД. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. One of the new methods for assessing atrial cardiomyopathy is speckle tracking echocardiography, which allows for non-invasive diagnosis of left atrial (LA) dysfunction.</p></sec><sec><title>Purpose</title><p>Purpose. Determination the diagnostic role of LA myocardial deformation in the development of cardioembolic stroke (CS).</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 150 patients in the acute period of ischemic stroke (IS). The patients were divided into 2 groups: group I consisted of 30 patients with EI, group II — 120 people with other etiopathogenetic types of IS. All patients underwent transthoracic echocardiography with assessment of myocardial deformation of the left chambers of the heart.</p></sec><sec><title>Results</title><p>Results. The values of LA diameter, volume and indexed volume in group I were greater and amounted to 39 [36.3; 41] mm, 65.5 [55.8; 77.5] ml and 37 [25.8; 44.8] ml/m2, respectively. Indicators of myocardial deformation of the LA in patients of group I went beyond normal values and differed statistically significantly, amounting to 14.1 [5.25; 22]%, −10 [−11.5; −5.25]% and −4.25 [−10.4; 0.575]% for the deformation indicators in the reservoir phase (LP-SrKD), conductor (LPSprKD) and contraction (LPSkKD), respectively. When conducting multivariate regression analysis adjusted for confounders, LPSprKD and LPScrKD remained statistically significant indicators. Thus, each subsequent increase in the LPScrCD indicator by 1% increased the chances of CEI by 1.151 times (OR: 1.151, 95% CI: 1.043–1.271, p = 0.006), each subsequent increase in the LPScrCD indicator by 1% — by 1.11 times (OR : 1.102, 95% CI: 1.032–1.178, p = 0.004). ROC analysis was performed to determine the optimal diagnostic threshold and diagnostic performance of strain analysis in relation to CS.</p></sec><sec><title>Conclusions</title><p>Conclusions. In group I, statistically significantly higher values of LA sizes and volumes were recorded, and LA deformation indicators were statistically significantly different from the indicators of group II and were outside the normal range. It was established that statistically significant indicators of LA myocardial deformation, allowing for the diagnosis of CEI, were LPSprCD and LPScrCD. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>деформация миокарда</kwd><kwd>левое предсердие</kwd><kwd>кардиоэмболический инсульт</kwd><kwd>эхокардиография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>myocardial deformation</kwd><kwd>left atrium</kwd><kwd>cardioembolic stroke</kwd><kwd>echocardiography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Стаховская Л.В., Клочихина О.А., Богатырева М.Д., Коваленко В.В. Эпидемиология инсульта в России по результатам территориально-популяционного регистра (2009–2010). Журнал неврологии и психиатрии им. С.С. 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