r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2024-29-5-23-30r-n-j-619Research ArticleОБЗОРЫREVIEWSРоль нейротрофических факторов в ходе восстановительной терапии у пациентов с детским церебральным параличомThe role of neurotrophic factors during rehabilitation therapy in patients with cerebral palsyhttps://orcid.org/0000-0003-0958-130XКорсунскаяЛ. Л.KorsunskayaL. L.

Симферополь

Simferopol

neurocrimea@mail.ruhttps://orcid.org/0000-0003-4590-3580АгееваЕ. С.AgeevaE. S.

Симферополь

Simferopol

https://orcid.org/0000-0002-6996-4823ЛаринаН. В.LarinaN. V.

Симферополь

Simferopol

Крымский федеральный университет им. В.И. Вернадского, Медицинский институт им. С.И. ГеоргиевскогоРоссияV.I. Vernadsky Crimean Federal University, Medical Institute named after S.I. GeorgievskyRussian Federation2024060120252952330Copyright © Корсунская Л.Л., Агеева Е.С., Ларина Н.В., 20252025Корсунская Л.Л., Агеева Е.С., Ларина Н.В.Korsunskaya L.L., Ageeva E.S., Larina N.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/619

Результаты исследования динамики концентрации нейротрофических факторов (НТФ) в крови пациентов с детским церебральным параличом (ДЦП) после применения методики «неинвазивный интерфейс мозг-компьютер-экзокисть» с биологической обратной связью продемонстрировали снижение уровня НТФ на 10-й день после проведения реабилитационных тренингов, что сопровождалось улучшением двигательных, когнитивных функций и эмоционального статуса пациентов. При этом различные НТФ продемонстрировали разный уровень изменения концентрации. Проведен анализ литературы, посвященной механизмам влияния НТФ на процессы нейропластичности. В обзоре представлены результаты исследований механизмов влияния НТФ на различные функции мозга и способность проникать через гематоэнцефалический барьер. Анализ данных литературы свидетельствует об активном вовлечении НТФ в механизмы функциональной перестройки и их возможной роли в восстановлении двигательной активности у детей с ДЦП, положительном влиянии на когнитивные функции и эмоциональный статус.

Blood concentration of neurotrophic factors (NTF) in patients with cerebral palsy after the use of the “non-invasive brain-computer-exohand interface” technique demonstrated a decrease in the level of NTFs on the 10th day after rehabilitation training, which was accompanied by an improvement in motor, cognitive functions and emotional status of patients. Moreover, different NTFs demonstrated different levels of concentration changes. The literature base about influence of NTFs on the mechanisms of neuroplasticity was analyzed. The review presents the results of studies on the therapeutic targets of NTFs and their different abilities to penetrate the blood-brain barrier, which apparently explains their participation in the processes of neuroplasticity. Analysis of literature data indicates the active involvement of NTF in the mechanisms of functional restructuring and their possible role in restoring motor activity in children with cerebral palsy, positive effect on cognitive functions and emotional status.

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The authors declare that there are no conflicts of interest present.