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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">r-n-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский неврологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian neurological journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2658-7947</issn><issn pub-type="epub">2686-7192</issn><publisher><publisher-name>МИА</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/2658-7947-2024-29-4-54-61</article-id><article-id custom-type="elpub" pub-id-type="custom">r-n-j-607</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL RESEARCHES AND CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Клиническая характеристика и долгосрочный прогноз при вертебрально-базилярном инсульте</article-title><trans-title-group xml:lang="en"><trans-title>Clinical characteristic and long-term prognosis in vertebrobasilar stroke</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4680-3250</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Еремина</surname><given-names>Ю. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Eremina</surname><given-names>Y. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Красноярск; Пермь</p></bio><bio xml:lang="en"><p>Krasnoyarsk; Perm</p></bio><email xlink:type="simple">ereminajuliya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6061-8118</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулеш</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulesh</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пермь</p></bio><bio xml:lang="en"><p>Perm</p></bio><email xlink:type="simple">aleksey.kulesh@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хало</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Halo</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Красноярск</p></bio><bio xml:lang="en"><p>Krasnoyarsk</p></bio><email xlink:type="simple">halo_natalya@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1854-8686</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Астанин</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Astanin</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Красноярская межрегиональная клиническая больница №20 им. И.С. Берзона» ; Пермский государственный медицинский университет им. академика Е.А. Вагнера<country>Россия</country></aff><aff xml:lang="en">Krasnoyarsk Interdistrict Clinical Hospital №20 named after I.S. Berzona ; Acad. E.A. Vagner Perm State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Пермский государственный медицинский университет им. академика Е.А. Вагнера ; Городская клиническая больница №4<country>Россия</country></aff><aff xml:lang="en">Acad. E.A. Vagner Perm State Medical University ; City Clinical Hospital №4<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Красноярская межрегиональная клиническая больница №20 им. И.С. Берзона»<country>Россия</country></aff><aff xml:lang="en">Krasnoyarsk Interdistrict Clinical Hospital №20 named after I.S. Berzona<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова<country>Россия</country></aff><aff xml:lang="en">Russian National Research Medical University named after N.I. Pirogov<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>05</day><month>11</month><year>2024</year></pub-date><volume>29</volume><issue>4</issue><fpage>54</fpage><lpage>61</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Еремина Ю.О., Кулеш А.А., Хало Н.В., Астанин П.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Еремина Ю.О., Кулеш А.А., Хало Н.В., Астанин П.А.</copyright-holder><copyright-holder xml:lang="en">Eremina Y.O., Kulesh A.A., Halo N.V., Astanin P.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.r-n-j.com/jour/article/view/607">https://www.r-n-j.com/jour/article/view/607</self-uri><abstract><p>Вертебрально-базилярный инсульт (ВБИ) составляет 20–25% в структуре ишемического инсульта, однако клинические особенности и долгосрочное течение заболевания в отечественной популяции мало изучены.</p><sec><title>Цель исследования</title><p>Цель исследования: проанализировать клинические особенности острого периода ВБИ и рассчитать 5-летний риск развития сердечно-сосудистых событий и смерти.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Изучены данные 1569 пациентов с ишемическим инсультом. Проведен анализ жалоб, неврологического статуса, данных нейровизуализации; применены шкалы NIHSS и POST-NIHSS. Для оценки предикторов пятилетней летальности построена логистическая регрессионная модель.</p></sec><sec><title>Результаты</title><p>Результаты. Из 1569 пациентов ВБИ диагностирован у 386 пациентов (25%), подтвержден с помощью КТ у 147 (9,4%). Ведущие жалобы у пациентов с ВБИ: головокружение (51%), неустойчивость при ходьбе (37%) и нечеткость речи (39%). 49% пациентов при поступлении имели малый неврологический дефицит, наиболее частыми нарушениями явились атаксия, прозопарез, дизартрия и нистагм. Более чем у 60% пациентов не удалось установить подтип инсульта, несмотря на проведенный диагностический поиск. Внутривенный тромболизис или тромбэктомия были выполнены всего 3 пациентам (1,7%). В течение 5 лет у 19,4% пациентов развился повторный ишемический инсульт у 0,8% — кровоизлияние в мозг, у 10,1% — инфаркт миокарда, более трети (37,2%) пациентов умерли. Предикторами смертности явились увеличение возраста, наличие сердечно-сосудистых заболеваний, прозопарез в дебюте заболевания.</p></sec><sec><title>Заключение</title><p>Заключение. ВБИ характеризуется преимущественно неспецифической клинической картиной заболевания, в половине случаев малым неврологическим дефицитом, недостаточной информативностью первичной компьютерной томографии головного мозга, низкой частотой проведения внутривенного тромболизиса и тромбэктомии, трудностями определения причины инсульта, а также высоким риском повторного инсульта и смерти в течение 5 лет.</p></sec></abstract><trans-abstract xml:lang="en"><p>Vertebrobasilar stroke (VBS) is 20-25% of the ischemic stroke structure, however, the clinical features and long-term outcome of the disease studied poorly in the domestic population.</p><p>The aim of the study was to analyze the clinical features of the acute period of VBS and calculate the 5-year risk of cardiovascular events and death.</p><sec><title>Material and methods</title><p>Material and methods. We analyzed the data of 1569 patients with ischemic stroke. There were analyses of patient complaints, neurological status, brain imaging, NIHSS and POST-NIHSS. The logistic regression model was built for an integral assessment of predictors of five-year mortality.</p></sec><sec><title>Results</title><p>Results. 386 (25%) patients with VBS were diagnosed and 147 (9,4%) cases of VBS were diagnosed with CT-scan. The top complaints were dizziness, unsteadiness and blurred speech. 72 (48,9%) patients were low neurological deficit, the most common neurological syndromes were ataxia, prosoparesis, hemiparesis, dysarthria and nystagmus. More than 60% of patients had an unspecified stroke subtype, despite the diagnostic search performed. The 19,4% patients were recurrent ischemic stroke and 37,2% patients died. Predictors of mortality were age and the presence of cardiovascular disease. Conclusion. Patients with VBS are characterized by a predominantly nonspecific clinical picture of the disease, in half of the cases a minor neurological deficit, insufficient information content of the initial computed tomography of the brain, a low frequency of intravenous thrombolysis, difficulties in determining the cause of stroke and a high risk of recurrent stroke and death within 5 years.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>вертебрально-базилярный инсульт</kwd><kwd>клиническая характеристика</kwd><kwd>прогноз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>vertebrobasilar stroke</kwd><kwd>clinical characteristics</kwd><kwd>prognosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кулеш А.А., Демин Д.А., Виноградов О.И. Дифференциальная диагностика ишемического инсульта в артериях вертебробазилярной системы. 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