r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2024-29-4-5-15r-n-j-602Research ArticleОБЗОРЫREVIEWSСтруктурная эпилепсия: современное состояние проблемыStructural epilepsy: current state of the problemhttps://orcid.org/0000-0002-7682-6672МаксимоваМ. Ю.MaksimovaM. Yu.

Москва

Moscow 

ncnmaximova@mail.ruhttps://orcid.org/0000-0003-2970-8136ГулевскаяТ. С.GulevskayaT. S.

Москва

Moscow 

Научный центр неврологииРоссияResearch Center of NeurologyRussian Federation202405112024294515Copyright © Максимова М.Ю., Гулевская Т.С., 20242024Максимова М.Ю., Гулевская Т.С.Maksimova M.Y., Gulevskaya T.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/602

В обзоре освещены современные представления о фундаментальных и клинических аспектах структурной эпилепсии. Отмечается вклад в изучение этой проблемы высокоинформативных нейровизуализиционных, электрофизиологических и патоморфологических методов диагностики. Приведены современные данные о патогенезе и клинической картине наиболее распространенных форм фармакорезистентной эпилепсии: склероза гиппокампа, фокальной корковой дисплазии и методах их хирургической коррекции. Рассматриваются перспективные направления фундаментальных клинических и экспериментальных исследований, направленных на изучение механизмов эпилептогенеза с целью разработки эффективных методов профилактики и лечения.

This review emphasizes modern conceptions in the fundamental and clinical aspects of structural epilepsy. Highly informative neuroimaging, electrophysiological and pathomorphological diagnostic methods contribution to the study of this problem is noted. Current understanding of the pathogenesis and clinical picture of the most common types of drug resistant epilepsy are presented: hippocampal sclerosis, focal cortical dysplasia and their surgical correction methods. We considered perspective directions of fundamental clinical and experimental research, focusing on the study of epileptogenesis mechanisms and developing effective methods for prevention and treatment.

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The authors declare that there are no conflicts of interest present.