<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">r-n-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский неврологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian neurological journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2658-7947</issn><issn pub-type="epub">2686-7192</issn><publisher><publisher-name>МИА</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/2658-7947-2023-28-1-67-72</article-id><article-id custom-type="elpub" pub-id-type="custom">r-n-j-398</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURE</subject></subj-group></article-categories><title-group><article-title>Комплексный подход к паллиативной медицинской помощи при неврологической патологии</article-title><trans-title-group xml:lang="en"><trans-title>A comprehensive approach to palliative care in neurological pathology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4293-3285</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">vrach315@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1256-2695</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьева</surname><given-names>Э. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Soloviova</surname><given-names>E. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">ellasolovieva@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0887-4995</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бонкало</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Bonkalo</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">bonkalotatyanaivanovna@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0390-194X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шмелева</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shmeleva</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">89151479832@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Soloviova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">solomar62@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I. Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУ «Научно-исследовательский институт организации здравоохранения и медицинского менеджмента Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Health Organization and Medical Management of the Moscow Department of Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Московский университет технологий и управления имени К.Г. Разумовского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow University of Technology and Management named after K.G. Razumovsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>16</day><month>03</month><year>2023</year></pub-date><volume>28</volume><issue>1</issue><fpage>67</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Орлова Н.В., Соловьева Э.Ю., Бонкало Т.И., Шмелева С.В., Соловьева М.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Орлова Н.В., Соловьева Э.Ю., Бонкало Т.И., Шмелева С.В., Соловьева М.В.</copyright-holder><copyright-holder xml:lang="en">Orlova N.V., Soloviova E.Y., Bonkalo T.I., Shmeleva S.V., Soloviova M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.r-n-j.com/jour/article/view/398">https://www.r-n-j.com/jour/article/view/398</self-uri><abstract><p>Паллиативная медицинская помощь (ПМП) неврологическим больным — это подход к уходу за пациентами и помощь их семьям, сталкивающимся с хроническими, прогрессирующими, ограничивающими жизнь и инвалидизирующими состояниями. Особенность ПМП в неврологии обусловлена значительной продолжительностью поздних стадий многих неврологических заболеваний и отличительными чертами некоторых заболеваний (когнитивные расстройства, психические расстройства, нарушение речи, нарушение функции тазовых органов, парезы, судороги, развитие контрактур и т.д.), а также наличием сопутствующих общих симптомов (нарушение питания, дисфагия, боль, пролежни, дыхательная недостаточность и др.). В статье обсуждается ПМП при некоторых неврологических заболеваниях. Описаны симптомы, развивающиеся в далеко зашедших стадиях, требующие паллиативной помощи, медикаментозные и немедикаментозные методы лечения, рассмотрены мероприятия, направленные на улучшение качества жизни и профилактику осложнений.</p></abstract><trans-abstract xml:lang="en"><p>Palliative care for neurological patients is an approach to patient care and assistance to their families facing chronic, progressive, life-limiting and disabling conditions. The peculiarity of palliative care in neurology is due to the signifi cant duration of the late stages of many neurological diseases and the distinctive features of some diseases (cognitive disorders, mental disorders, speech disorders, pelvic organ dysfunction, paresis, convulsions, contracture development, etc.), as well as the presence of concomitant common symptoms (eating disorders, pain, bedsores, respiratory failure, etc.). The symptoms developing in the advanced stages of neurological diseases requiring palliative care are described. Drug and non-drug methods of treatment are described, measures aimed at improving the quality of life and preventing complications are considered. The features of pharmacotherapy, taking into account their interaction with drugs for the treatment of concomitant pathology, are considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>неврологические заболевания</kwd><kwd>паллиативная медицинская помощь</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neurology</kwd><kwd>diseases</kwd><kwd>palliative care</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Provinciali L., Carlini G., Tarquini D., Defanti C.A., Veronese S., Pucci E. Need for palliative care for neurological diseases. Neurol Sci. 2016;37(10):1581–7. doi: 10.1007/s10072-016-2614-x</mixed-citation><mixed-citation xml:lang="en">Provinciali L., Carlini G., Tarquini D., Defanti C.A., Veronese S., Pucci E. Need for palliative care for neurological diseases. Neurol Sci. 2016;37(10):1581–7. doi: 10.1007/s10072-016-2614-x</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Higginson I.J., Gao W., Saleem T.Z. et al. Symptoms and quality of life in late stage Parkinson syndromes: a longitudinal community study of predictive factors. PLoS One. 2012;7(11):e46327. doi: 10.1371/journal.pone.0046327</mixed-citation><mixed-citation xml:lang="en">Higginson I.J., Gao W., Saleem T.Z. et al. Symptoms and quality of life in late stage Parkinson syndromes: a longitudinal community study of predictive factors. PLoS One. 2012;7(11):e46327. doi: 10.1371/journal.pone.0046327</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Congedo M., Causarano R.I., Alberti F., Chaudhuri K.R., Burman R., McCrone P., Leigh P.N. Bioethics and Palliative Care in Neurology Study Group of Italian Society of Neurology. Ethical issues in end of life treatments for patients with dementia. Eur. J. Neurol. 2010;17(6):774–9. doi: 10.1111/j.1468-1331.2010.02991.x</mixed-citation><mixed-citation xml:lang="en">Congedo M., Causarano R.I., Alberti F., Chaudhuri K.R., Burman R., McCrone P., Leigh P.N. Bioethics and Palliative Care in Neurology Study Group of Italian Society of Neurology. Ethical issues in end of life treatments for patients with dementia. Eur. J. Neurol. 2010;17(6):774–9. doi: 10.1111/j.1468-1331.2010.02991.x</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Boersma I., Miyasaki J., Kutner J., Kluger B. Palliative care and neurology: time for a paradigm shift. Neurology. 2014;83(6):561– 7. doi:10.1212/WNL.0000000000000674</mixed-citation><mixed-citation xml:lang="en">Boersma I., Miyasaki J., Kutner J., Kluger B. Palliative care and neurology: time for a paradigm shift. Neurology. 2014;83(6):561– 7. doi:10.1212/WNL.0000000000000674</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Borasio G.D. The role of palliative care in patients with neurological diseases. Nat. Rev. Neurol. 2013;9(5):292–5. doi: 10.1038/nrneurol.2013.49</mixed-citation><mixed-citation xml:lang="en">Borasio G.D. The role of palliative care in patients with neurological diseases. Nat. Rev. Neurol. 2013;9(5):292–5. doi: 10.1038/nrneurol.2013.49</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Turner-Stokes L., Sykes N., Silber E., Khatri A., Sutton L., Yuong E. From diagnosis to death: exploring the interface between neurology, rehabilitation and palliative care in managing people with long-term neurological conditions. Clin. Med. (Lond.). 2007;7(2):129–36. doi: 10.7861/clinmedicine.7-2-129</mixed-citation><mixed-citation xml:lang="en">Turner-Stokes L., Sykes N., Silber E., Khatri A., Sutton L., Yuong E. From diagnosis to death: exploring the interface between neurology, rehabilitation and palliative care in managing people with long-term neurological conditions. Clin. Med. (Lond.). 2007;7(2):129–36. doi: 10.7861/clinmedicine.7-2-129</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mitchell S.L., Kiely D.K., Hamel M.B. Dying with advanced dementia in the nursing home. Arch. Intern. Med. 2004;164(3):321–6. doi: 10.1001/archinte.164.3.321</mixed-citation><mixed-citation xml:lang="en">Mitchell S.L., Kiely D.K., Hamel M.B. Dying with advanced dementia in the nursing home. Arch. Intern. Med. 2004;164(3):321–6. doi: 10.1001/archinte.164.3.321</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Chahine L.M., Malik B., Davis M. Palliative care needs of patients with neurologic or neurosurgical conditions. Eur. J. Neurol. 2008;15(12):1265–72. doi: 10.1111/j.1468-1331.2008.02319.x</mixed-citation><mixed-citation xml:lang="en">Chahine L.M., Malik B., Davis M. Palliative care needs of patients with neurologic or neurosurgical conditions. Eur. J. Neurol. 2008;15(12):1265–72. doi: 10.1111/j.1468-1331.2008.02319.x</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Creutzfeldt C.J., Kluger B., Kelly A.G., Lemmon M., Hwang D., Galifi anakis N.B. et al. Neuropalliative care: Priorities to move the fi eld forward. Neurology. 2018;91(5):217–226. doi: 10.1212/WNL.0000000000005916</mixed-citation><mixed-citation xml:lang="en">Creutzfeldt C.J., Kluger B., Kelly A.G., Lemmon M., Hwang D., Galifi anakis N.B. et al. Neuropalliative care: Priorities to move the fi eld forward. Neurology. 2018;91(5):217–226. doi: 10.1212/WNL.0000000000005916</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Song J., Youn J., Huh Y.E. Motor and Non-motor Symptoms Associated with Exercise Behavior in Parkinson’s Disease Patients: Factors Diff er between Patients With and Without Postural Instability. Front Neurol. 2021;12:772391. doi: 10.3389/fneur.2021.772391</mixed-citation><mixed-citation xml:lang="en">Song J., Youn J., Huh Y.E. Motor and Non-motor Symptoms Associated with Exercise Behavior in Parkinson’s Disease Patients: Factors Diff er between Patients With and Without Postural Instability. Front Neurol. 2021;12:772391. doi: 10.3389/fneur.2021.772391</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации МЗ РФ. Рассеянный склероз. 2018:164 с. https://diseases.medelement.com/</mixed-citation><mixed-citation xml:lang="en">Klinicheskie rekomendacii MZ RF. Rasseyannyj skleroz. 2018:164 p. (In Russ.)]. https://diseases.medelement.com/</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Schwab R.S, England A.C. Projection Technique for Evaluating Surgery in Parkinson’s Disease. In: Third Symposium on Parkinson’s Disease, Gillingham J.F. and Donaldson I.M.L., eds. Edinburgh, Livingstone, 1969:152–157 ID: 80169192 https://www.semanticscholar.org/paper/</mixed-citation><mixed-citation xml:lang="en">Schwab R.S, England A.C. Projection Technique for Evaluating Surgery in Parkinson’s Disease. In: Third Symposium on Parkinson’s Disease, Gillingham J.F. and Donaldson I.M.L., eds. Edinburgh, Livingstone, 1969:152–157 ID: 80169192 https://www.semanticscholar.org/paper/</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hoehn M.M., Yahr M.D. Parkinsonism: onset, progression and mortality. Neurology. 1967;17(5):427–42. doi: 10.1212/wnl.17.5.427</mixed-citation><mixed-citation xml:lang="en">Hoehn M.M., Yahr M.D. Parkinsonism: onset, progression and mortality. Neurology. 1967;17(5):427–42. doi: 10.1212/wnl.17.5.427</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mahoney F., Barthel D. W. Functional evaluation; the Barthel index. A simple index of the independence useful in scoring improvement in the rehabilitation of the chronically ill. Maryland state medical journal. 1965. ID: 80218831 https://www.semanticscholar.org/author</mixed-citation><mixed-citation xml:lang="en">Mahoney F., Barthel D. W. Functional evaluation; the Barthel index. A simple index of the independence useful in scoring improvement in the rehabilitation of the chronically ill. Maryland state medical journal. 1965. ID: 80218831 https://www.semanticscholar.org/author</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Belkin A.A., Rudnik E.N., Belkin V.A. et al. Optimization of StepBy-Step Care for Patients in Intensive Care Units Based on Grade 6 of the Rehabilitation Routing Scale. Physical and rehabilitation medicine, medical rehabilitation. 2021;3(1):142–148. doi: 10.36425/rehab64082</mixed-citation><mixed-citation xml:lang="en">Belkin A.A., Rudnik E.N., Belkin V.A. et al. Optimization of StepBy-Step Care for Patients in Intensive Care Units Based on Grade 6 of the Rehabilitation Routing Scale. Physical and rehabilitation medicine, medical rehabilitation. 2021;3(1):142–148. doi: 10.36425/rehab64082</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Диагностика и лечение дисфагии при заболеваниях центральной нервной системы. Клинические рекомендации. Утверждено профильной комиссией по медицинской реабилитации Экспертного совета МЗ РФ. 2013:38 с. https://diseases.medelement.com/disease</mixed-citation><mixed-citation xml:lang="en">Diagnostika i lechenie disfagii pri zabolevaniyah central’noj nervnoj sistemy. Klinicheskie rekomendacii. Utverzhdeno profi l’noj komissiej po medicinskoj reabilitacii Ekspertnogo Soveta MZ RF. 2013:38 p. (In Russ.)]. https://diseases.medelement.com/disease</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">American Geriatrics Society Ethics Committee and Clinical Practice and Models of Care Committee. American Geriatrics Society feeding tubes in advanced dementia position statement. J. Am. Geriatr. Soc. 2014;62(8):1590–3. doi: 10.1111/jgs.12924</mixed-citation><mixed-citation xml:lang="en">American Geriatrics Society Ethics Committee and Clinical Practice and Models of Care Committee. American Geriatrics Society feeding tubes in advanced dementia position statement. J. Am. Geriatr. Soc. 2014;62(8):1590–3. doi: 10.1111/jgs.12924</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas S., MacMahon D. Parkinson’s disease, palliative care and older people: Part 1. Nurs. Older People. 2004;16(1):22–6. doi: 10.7748/nop2004.03.16.1.22.c2290</mixed-citation><mixed-citation xml:lang="en">Thomas S., MacMahon D. Parkinson’s disease, palliative care and older people: Part 1. Nurs. Older People. 2004;16(1):22–6. doi: 10.7748/nop2004.03.16.1.22.c2290</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Golla H., Galushko M., Pfaff H., Voltz R. Unmet needs of severely aff ected multiple sclerosis patients: the health professionals’ view. Palliat Med. 2012;26(2):139–51. doi: 10.1177/0269216311401465</mixed-citation><mixed-citation xml:lang="en">Golla H., Galushko M., Pfaff  H., Voltz R. Unmet needs of severely aff ected multiple sclerosis patients: the health professionals’ view. Palliat Med. 2012;26(2):139–51. doi: 10.1177/0269216311401465</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ahuja C.S., Wilson J.R., Nori S. et al. Traumatic spinal cord injury. Nat. Rev. Dis. Primers. 2017;3:17018. doi: 10.1038/nrdp.2017.18</mixed-citation><mixed-citation xml:lang="en">Ahuja C.S., Wilson J.R., Nori S. et al. Traumatic spinal cord injury. Nat. Rev. Dis. Primers. 2017;3:17018. doi: 10.1038/nrdp.2017.18</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">van den Berg M.E.L, Castellote J.M., Pedro-Cuesta J., Mahillo-Fernandez I. Survival after spinal cord injury: a systematic review. J. of Neurotrauma. 2010;27(8):1517–28. doi:10.1089/neu.2009.1138</mixed-citation><mixed-citation xml:lang="en">van den Berg M.E.L, Castellote J.M., Pedro-Cuesta J., Mahillo-Fernandez I. Survival after spinal cord injury: a systematic review. J. of Neurotrauma. 2010;27(8):1517–28. doi:10.1089/neu.2009.1138</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Payne S., Burton C., Addington-Hall J., Jones A. End-of-life issues in acute stroke care: a qualitative study of the experiences and preferences of patients and families. Palliat. Med. 2010; 24(2):146–53. doi: 10.1177/0269216309350252</mixed-citation><mixed-citation xml:lang="en">Payne S., Burton C., Addington-Hall J., Jones A. End-of-life issues in acute stroke care: a qualitative study of the experiences and preferences of patients and families. Palliat. Med. 2010; 24(2):146–53. doi: 10.1177/0269216309350252</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Горелик С.Г., Ильницкий А.Н., Прощаев К.И. и др. Опросники и шкалы в геронтологии и гериатрии. GERONTOLOGY Scientifi c Journal. 2021;9(1):90 c. http://gerontology.su</mixed-citation><mixed-citation xml:lang="en">Gorelik S.G., Il’nickij A.N., Proshchaev K.I. i dr. Oprosniki i shkaly v gerontologii i geriatrii GERONTOLOGY Scientifi c Journal. 2021;9(1):90 p. (In Russ.)]. http://gerontology.su</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Provinciali L., Carlini G., Tarquini D. et al. Need for palliative care for neurological diseases. Neurol. Sci. 2016;37(10):1581–7. doi: 10.1007/s10072-016-2614-x</mixed-citation><mixed-citation xml:lang="en">Provinciali L., Carlini G., Tarquini D. et al. Need for palliative care for neurological diseases. Neurol. Sci. 2016;37(10):1581–7. doi: 10.1007/s10072-016-2614-x</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Payne S., Burton C., Addington-Hall J., Jones A. End-of-life issues in acute stroke care: a qualitative study of the experiences and preferences of patients and families. Palliat. Med. 2010;24(2):146–53. doi: 10.1177/0269216309350252</mixed-citation><mixed-citation xml:lang="en">Payne S., Burton C., Addington-Hall J., Jones A. End-of-life issues in acute stroke care: a qualitative study of the experiences and preferences of patients and families. Palliat. Med. 2010;24(2):146–53. doi: 10.1177/0269216309350252</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Mitchell S.L., Teno J.M., Kiely D.K. et al. The clinical course of advanced dementia. N. Engl. J. Med. 2009;361(16):1529–38. doi: 10.1056/NEJMoa0902234</mixed-citation><mixed-citation xml:lang="en">Mitchell S.L., Teno J.M., Kiely D.K. et al. The clinical course of advanced dementia. N. Engl. J. Med. 2009;361(16):1529–38. doi: 10.1056/NEJMoa0902234</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Gove D., Sparr S., Dos Santos Bernardo A.M., Cosgrave M.P., Jansen S., Martensson B., Pointon B., Tudose C., Holmerova I. Recommendations on end-of-life care for people with dementia. J. Nutr. Health Aging. 2010;14(2):136–9. doi: 10.1007/s12603-0090229-0</mixed-citation><mixed-citation xml:lang="en">Gove D., Sparr S., Dos Santos Bernardo A.M., Cosgrave M.P., Jansen S., Martensson B., Pointon B., Tudose C., Holmerova I. Recommendations on end-of-life care for people with dementia. J. Nutr. Health Aging. 2010;14(2):136–9. doi: 10.1007/s12603-0090229-0</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kahveci K., Dinçer M., Doger C., Yaricı A.K. Traumatic brain injury and palliative care: a retrospective analysis of 49 patients receiving palliative care during 2013–2016 in Turkey. Neural Regen. Res. 2017;12(1):77–83. doi: 10.4103/1673-5374.198987</mixed-citation><mixed-citation xml:lang="en">Kahveci K., Dinçer M., Doger C., Yaricı A.K. Traumatic brain injury and palliative care: a retrospective analysis of 49 patients receiving palliative care during 2013–2016 in Turkey. Neural Regen. Res. 2017;12(1):77–83. doi: 10.4103/1673-5374.198987</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Solari A., Giordano A., Grasso M.G. et al. PeNSAMI Project. Home-based palliative approach for people with severe multiple sclerosis and their carers: study protocol for a randomized controlled trial. Trials. 2015;16:184. doi: 10.1186/s13063-015-0695-0 Erratum in: Trials. 2016;17:89. Erratum in: Trials. 2017;18(1):35.</mixed-citation><mixed-citation xml:lang="en">Solari A., Giordano A., Grasso M.G. et al. PeNSAMI Project. Home-based palliative approach for people with severe multiple sclerosis and their carers: study protocol for a randomized controlled trial. Trials. 2015;16:184. doi: 10.1186/s13063-015-0695-0 Erratum in: Trials. 2016;17:89. Erratum in: Trials. 2017;18(1):35.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Walbert T., Khan M. End-of-life symptoms and care in patients with primary malignant brain tumors: a systematic literature review. J. Neurooncol. 2014;117(2):217–24. doi: 10.1007/s11060-014-13936</mixed-citation><mixed-citation xml:lang="en">Walbert T., Khan M. End-of-life symptoms and care in patients with primary malignant brain tumors: a systematic literature review. J. Neurooncol. 2014;117(2):217–24. doi: 10.1007/s11060-014-13936</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Agar M.R., Lawlor P.G., Quinn S. et al. Effi cacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: a randomized clinical trial. JAMA Intern. Med. 2017;177:34–42. doi: 10.1001/jamainternmed.2016.7491/</mixed-citation><mixed-citation xml:lang="en">Agar M.R., Lawlor P.G., Quinn S. et al. Effi  cacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: a randomized clinical trial. JAMA Intern. Med. 2017;177:34–42. doi: 10.1001/jamainternmed.2016.7491/</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Veronese S., Gallo G., Valle A. et al. Specialist palliative care improves the quality of life in advanced neurodegenerative disorders: NE-PAL, a pilot randomised controlled study. BMJ Support Palliat. Care. 2017;7(2):164–172. https://doi.org/10.1136/bmjspcare-2014-000788</mixed-citation><mixed-citation xml:lang="en">Veronese S., Gallo G., Valle A. et al. Specialist palliative care improves the quality of life in advanced neurodegenerative disorders: NE-PAL, a pilot randomised controlled study. BMJ Support Palliat. Care. 2017;7(2):164–172. https://doi.org/10.1136/bmjspcare-2014-000788</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
