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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">r-n-j</journal-id><journal-title-group><journal-title xml:lang="ru">Российский неврологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian neurological journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2658-7947</issn><issn pub-type="epub">2686-7192</issn><publisher><publisher-name>МИА</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/2658-7947-2022-27-5-78-84</article-id><article-id custom-type="elpub" pub-id-type="custom">r-n-j-364</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL RESEARCHES AND CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Питание в профилактике и лечении пролежней у больных, перенесших инсульт</article-title><trans-title-group xml:lang="en"><trans-title>Nutrition in the prevention and treatment of pressure ulcers in stroke patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4619-291X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Погожева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pogozheva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Москва </p></bio><bio xml:lang="en"><p> Moscow </p></bio><email xlink:type="simple">allapogozheva@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУН «ФИЦ питания питания и биотехнологии», Минобрнауки</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Centre of Nutrition and Biotechnology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>24</day><month>11</month><year>2022</year></pub-date><volume>27</volume><issue>5</issue><fpage>78</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Погожева А.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Погожева А.В.</copyright-holder><copyright-holder xml:lang="en">Pogozheva A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.r-n-j.com/jour/article/view/364">https://www.r-n-j.com/jour/article/view/364</self-uri><abstract><p>Инсульт является одной из наиболее важних причин смертности и инвалидизации во всем мире. У 16–20% пациентов с острым инсультом при поступлении, во время госпитализации и реабилитации наблюдается белково-энергетическая, а также микронутриентная недостаточность, что связано с неблагоприятным прогнозом и риском развития пролежней. Назначение таким пациентам высококалорийных смесей для перорального или зондового энтерального питания, содержащих повышенные количества белка, аргинина, витаминов А, Е, С и минеральных веществ (цинка и селена) антиоксидантной направленности, может оказывать положительное влияние на заживление язв. Включение в диетотерапию специализированных лечебных смесей может также снизить риск развития пролежней.</p></abstract><trans-abstract xml:lang="en"><p>Stroke is one of the most important causes of mortality and disability of the population worldwide. In 16–20% of patients with acute stroke at admission, during hospitalization and rehabilitation, protein-energy deficiency, as well as micronutrient insufficiency is observed, which is associated with an unfavorable prognosis and the development of pressure ulcers. The widespread use of high-calorie mixtures for oral or probe enteral nutrition for such patients, containing increased amounts of protein, arginine, vitamins A, E, C and minerals (zinc and selenium) of an antioxidant orientation, can have a positive effect on the healing of pressure ulcers. The inclusion of specialized therapeutic mixtures in diet therapy can also potentially reduce the risk of developing pressure ulcers.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инсульт</kwd><kwd>диета</kwd><kwd>пищевые вещества</kwd><kwd>энтеральное питание</kwd><kwd>пролежни</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stroke</kwd><kwd>diet</kwd><kwd>nutrients</kwd><kwd>enteral nutrition</kwd><kwd>pressure ulcers</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. Ишемический инсульт и транзиторная ишемическая атака у взрослых, 2021-2022-2023 (01.09.2021). Утверждены Минздравом РФ. [Clinical recommendations. Ischemic stroke and transient ischemic attack in adults, 2021-2022-2023 (01.09.2021) approved by the Ministry of Health of Russia. (In Russ.)]. https://legalacts.ru/doc/klinicheskie-rekomendatsii-ishemicheskii-insult-i-tranzitornajaishemicheskaja-ataka-u/</mixed-citation><mixed-citation xml:lang="en">Клинические рекомендации. Ишемический инсульт и транзиторная ишемическая атака у взрослых, 2021-2022-2023 (01.09.2021). Утверждены Минздравом РФ. [Clinical recommendations. Ischemic stroke and transient ischemic attack in adults, 2021-2022-2023 (01.09.2021) approved by the Ministry of Health of Russia. (In Russ.)]. https://legalacts.ru/doc/klinicheskie-rekomendatsii-ishemicheskii-insult-i-tranzitornajaishemicheskaja-ataka-u/</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Spatz E.S., Jiang X., Lu J., Masoudi F.A., Spertus J.A., Wang Y. et al. Qingdao Port Cardiovascular Health Study: a prospective cohort study. BMJ Open. 2015;5:e008403. https://doi.org/10.1136/bmjopen-2015-008403</mixed-citation><mixed-citation xml:lang="en">Spatz E.S., Jiang X., Lu J., Masoudi F.A., Spertus J.A., Wang Y. et al. Qingdao Port Cardiovascular Health Study: a prospective cohort study. BMJ Open. 2015;5:e008403. https://doi.org/10.1136/bmjopen-2015-008403</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Aquilani R., Sessarego P., Iadarola P., Barbieri А., Boschi F. Nutrition for brain recovery after ischemic stroke: an added value to rehabilitation. Nutrition in Clinical Practice. 2011;26(3):339–345. https://doi.org/10.1177/0884533611405793</mixed-citation><mixed-citation xml:lang="en">Aquilani R., Sessarego P., Iadarola P., Barbieri А., Boschi F. Nutrition for brain recovery after ischemic stroke: an added value to rehabilitation. Nutrition in Clinical Practice. 2011;26(3):339–345. https://doi.org/10.1177/0884533611405793</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bouziana S.D., Tziomalos K. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Journal of Nutrition and Metabolism. 2011;Nov.1–7. Article ID 167898. https://doi.org/10.1155/2011/167898</mixed-citation><mixed-citation xml:lang="en">Bouziana S.D., Tziomalos K. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Journal of Nutrition and Metabolism. 2011;Nov.1–7. Article ID 167898. https://doi.org/10.1155/2011/167898</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sisto I.R., Hauck M., Plentz R.D.M. Muscular Atrophy in Cardiovascular Disease. Adv. Exp. Med. Biol. 2018;1088:369–391.</mixed-citation><mixed-citation xml:lang="en">Sisto I.R., Hauck M., Plentz R.D.M. Muscular Atrophy in Cardiovascular Disease. Adv. Exp. Med. Biol. 2018;1088:369–391.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Нутрициология и клиническая диетология: национальное руководство. Под ред. В.А. Тутельяна, Д.Б. Никитюка. 2-е изд. Москва: ГЭОТАР-Медиа, 2021:1008 с. [Nutritionology and clinical dietetics: national guidelines. Edited by V.A. Tutelyan, D.B. Nikityuk. 2nd ed. Moscow: GEOTAR-Media, 2021:1008 p. (In Russ.)]. DOI: 10.33029/9704-6280-5-NKD-2021-1-1008</mixed-citation><mixed-citation xml:lang="en">Нутрициология и клиническая диетология: национальное руководство. Под ред. В.А. Тутельяна, Д.Б. Никитюка. 2-е изд. Москва: ГЭОТАР-Медиа, 2021:1008 с. [Nutritionology and clinical dietetics: national guidelines. Edited by V.A. Tutelyan, D.B. Nikityuk. 2nd ed. Moscow: GEOTAR-Media, 2021:1008 p. (In Russ.)]. DOI: 10.33029/9704-6280-5-NKD-2021-1-1008</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Talhada D., Santos R.С.А., Gonçalves I., Ruscher К. Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke. Front Neurol. 2019;10:1103. https://doi.org/10.3389/fneur.2019.01103</mixed-citation><mixed-citation xml:lang="en">Talhada D., Santos R.С.А., Gonçalves I., Ruscher К. Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke. Front Neurol. 2019;10:1103. https://doi.org/10.3389/fneur.2019.01103</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sabbouh T., Torbey M.T. Malnutrition in Stroke Patients: Risk Factors, Assessment, and Management. Neurocrit Care. 2018;29(3):374–384. https://doi.org/10.1007/s12028-017-0436-1</mixed-citation><mixed-citation xml:lang="en">Sabbouh T., Torbey M.T. Malnutrition in Stroke Patients: Risk Factors, Assessment, and Management. Neurocrit Care. 2018;29(3):374–384. https://doi.org/10.1007/s12028-017-0436-1</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Пыко М.Е., Богданов А.Р., Пыко А.А. Питание как фактор риска развития цереброваскулярной болезни и инсульта. Вопросы диетологии. 2020;10(1):20–27. [Pyko М.Е., Bogdanov А.R., Pyko А.А. Nutrition as a risk factor for the development of cerebrovascular disease and stroke. Vopr. dietol. (Nutrition). 2020;10(1):20–26 (In Russian)]. https://doi.org/10.20953/2224-5448-2020-1-20-26</mixed-citation><mixed-citation xml:lang="en">Пыко М.Е., Богданов А.Р., Пыко А.А. Питание как фактор риска развития цереброваскулярной болезни и инсульта. Вопросы диетологии. 2020;10(1):20–27. [Pyko М.Е., Bogdanov А.R., Pyko А.А. Nutrition as a risk factor for the development of cerebrovascular disease and stroke. Vopr. dietol. (Nutrition). 2020;10(1):20–26 (In Russian)]. https://doi.org/10.20953/2224-5448-2020-1-20-26</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Залетова Т.С. Потребности в восполнении энергозатрат у пациентов после перенесенного инсульта. Медицина. Социология. Философия. Прикладные исследования. 2020;3:21–24. [Zaletova T.S. The need to replenish energy consumption in patients after a stroke. Medicine. Sociology. Philosophy. Applied research. 2020;3:21–24].</mixed-citation><mixed-citation xml:lang="en">Залетова Т.С. Потребности в восполнении энергозатрат у пациентов после перенесенного инсульта. Медицина. Социология. Философия. Прикладные исследования. 2020;3:21–24. [Zaletova T.S. The need to replenish energy consumption in patients after a stroke. Medicine. Sociology. Philosophy. Applied research. 2020;3:21–24].</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Jenkins D.J.A., Spence J.D., Giovannucci E.L., Kim Y.-In., Josse R., Reinhold Vieth R. et al. Supplemental Vitamins and Minerals for CVD Prevention and Treatment. J Am Coll Cardiol. 2018;71(22):2570–84. https://doi.org/10.1016/j.jacc.2018.04.020</mixed-citation><mixed-citation xml:lang="en">Jenkins D.J.A., Spence J.D., Giovannucci E.L., Kim Y.-In., Josse R., Reinhold Vieth R. et al. Supplemental Vitamins and Minerals for CVD Prevention and Treatment. J Am Coll Cardiol. 2018;71(22):2570–84. https://doi.org/10.1016/j.jacc.2018.04.020</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Погожева А.В. Роль калия и магния в профилактике и лечении сердечно-сосудистых заболеваний. Consilium Medicum. 2020;22(10):76–79. [Pogozheva A.V. The role of potassium and magnesium for prevention and treatment of cardiovascular disease. Consilium Medicum. 2020;22(10):76–79. (In Russ.)]. https://doi.org/10.26442/20751753.2020.10.200336</mixed-citation><mixed-citation xml:lang="en">Погожева А.В. Роль калия и магния в профилактике и лечении сердечно-сосудистых заболеваний. Consilium Medicum. 2020;22(10):76–79. [Pogozheva A.V. The role of potassium and magnesium for prevention and treatment of cardiovascular disease. Consilium Medicum. 2020;22(10):76–79. (In Russ.)]. https://doi.org/10.26442/20751753.2020.10.200336</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Реабилитация в отделении реанимации и интенсивной терапии (РеабИТ). Методические рекомендации Союза реабилитологов России и Федерации анестезиологов и реаниматологов. Вестник интенсивной терапии имени А.И. Салтанова. 2022;2:7–40. [Clinical practice recommendations of the national Union of Physical and Rehabilitation Medicine Specialists of Russia and of the national Federation of Anesthesiologists and Reanimatologists. Russian Federation of anesthesiologists and reanimatologists guidelines. Annals of Critical Care. 2022;2:7–40. (In Russ.)]. https://doi.org/10.21320/1818-474X-2022-2-7-40</mixed-citation><mixed-citation xml:lang="en">Реабилитация в отделении реанимации и интенсивной терапии (РеабИТ). Методические рекомендации Союза реабилитологов России и Федерации анестезиологов и реаниматологов. Вестник интенсивной терапии имени А.И. Салтанова. 2022;2:7–40. [Clinical practice recommendations of the national Union of Physical and Rehabilitation Medicine Specialists of Russia and of the national Federation of Anesthesiologists and Reanimatologists. Russian Federation of anesthesiologists and reanimatologists guidelines. Annals of Critical Care. 2022;2:7–40. (In Russ.)]. https://doi.org/10.21320/1818-474X-2022-2-7-40</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">https://tvntv.co.uk/pressure-ulcers/reposition-reposition-andreposition-covid-19/15. https://tvs.org.uk/pressure-ulcer-prevention-and-management</mixed-citation><mixed-citation xml:lang="en">https://tvntv.co.uk/pressure-ulcers/reposition-reposition-andreposition-covid-19/15. https://tvs.org.uk/pressure-ulcer-prevention-and-management</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tannen A., Dassen Т., Halfens R.. Differences in prevalence of pressure ulcers between the Netherlands and Germany—associations between risk, prevention and occurrence of pressure ulcers in hospitals and nursing homes. J Clin Nurs. 2008;17(9):1237–44.</mixed-citation><mixed-citation xml:lang="en">Tannen A., Dassen Т., Halfens R.. Differences in prevalence of pressure ulcers between the Netherlands and Germany—associations between risk, prevention and occurrence of pressure ulcers in hospitals and nursing homes. J Clin Nurs. 2008;17(9):1237–44.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Neyens J.C.L., Cereda E., Meijer E.P., Lindholm C., Schols J.M.G.A. Arginine-enriched oral nutritional supplementation in the treatment of pressure ulcers: A literature review. Wound Medicine. 2017;16:46–51. http://dx.doi.org/10.1016Zj.wndm.2016.07.002</mixed-citation><mixed-citation xml:lang="en">Neyens J.C.L., Cereda E., Meijer E.P., Lindholm C., Schols J.M.G.A. Arginine-enriched oral nutritional supplementation in the treatment of pressure ulcers: A literature review. Wound Medicine. 2017;16:46–51. http://dx.doi.org/10.1016Zj.wndm.2016.07.002</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Iizaka S., Kaitani Т., Nakagami G., Sugama J., Sanada H. Clinical validity of the estimated energy requirement and the average protein requirement for nutritional status change and wound healing in older patients with pressure ulcers: a multicenter prospective cohort study. Geriatr. Gerontol. Int. 2015;15(11):1201–1209. https://doi.org/10.1111/ggi.12420. 10.1111/ggi.12420</mixed-citation><mixed-citation xml:lang="en">Iizaka S., Kaitani Т., Nakagami G., Sugama J., Sanada H. Clinical validity of the estimated energy requirement and the average protein requirement for nutritional status change and wound healing in older patients with pressure ulcers: a multicenter prospective cohort study. Geriatr. Gerontol. Int. 2015;15(11):1201–1209. https://doi.org/10.1111/ggi.12420. 10.1111/ggi.12420</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Posthauer M.E., Banks M., Dorner B., Schols J.M.G.A. The role of nutrition for pressure ulcer management: national pressure ulcer advisory panel, european pressure ulcer advisory panel, and pan pacific pressure injury alliance white paper. Adv. Skin Wound Care. 2015;28(4):175–188. https://doi.org/10.1097/01.ASW.0000461911.31139.62</mixed-citation><mixed-citation xml:lang="en">Posthauer M.E., Banks M., Dorner B., Schols J.M.G.A. The role of nutrition for pressure ulcer management: national pressure ulcer advisory panel, european pressure ulcer advisory panel, and pan pacific pressure injury alliance white paper. Adv. Skin Wound Care. 2015;28(4):175–188. https://doi.org/10.1097/01.ASW.0000461911.31139.62</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cereda E., Neyens J.C.L., Cаccialanza R., Rondanelli M., Schols J.M.G.A. Efficacy of a disease-specific nutritional support for pressure ulcer healing: a systematic review and metaanalysis. J Nutr Health Aging. 2017;21(6):655–661. https://doi.org/10.1007/s12603-016-0822-y</mixed-citation><mixed-citation xml:lang="en">Cereda E., Neyens J.C.L., Cаccialanza R., Rondanelli M., Schols J.M.G.A. Efficacy of a disease-specific nutritional support for pressure ulcer healing: a systematic review and metaanalysis. J Nutr Health Aging. 2017;21(6):655–661. https://doi.org/10.1007/s12603-016-0822-y</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Инновации в питании для взрослых: Ежегодное издание с каталогом. Выпуск 1. Под ред. В.А. Тутельяна, Д.Б. Никитюка, А.В. Погожевой, А.Е. Шестопалова, Т.С. Поповой. Москва: ООО «Медицинское информационное агентство», 2021:166 с. [Innovations in nutrition for adults: An annual publication with a catalog. Issue 1. Edited by V.A. Tutelyan, D.B. Nikityuk, A.V. Pogozheva, A.E. Shestopalov, T.S. Popova. Moscow: LLC “Medical Information Agency”, 2021:166 p. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Инновации в питании для взрослых: Ежегодное издание с каталогом. Выпуск 1. Под ред. В.А. Тутельяна, Д.Б. Никитюка, А.В. Погожевой, А.Е. Шестопалова, Т.С. Поповой. Москва: ООО «Медицинское информационное агентство», 2021:166 с. [Innovations in nutrition for adults: An annual publication with a catalog. Issue 1. Edited by V.A. Tutelyan, D.B. Nikityuk, A.V. Pogozheva, A.E. Shestopalov, T.S. Popova. Moscow: LLC “Medical Information Agency”, 2021:166 p. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Руководство по клиническому питанию. Под ред. В.М. Луфта. 3-е переизд. СПб.: «Арт Экспресс», 2016:275 с. [Guidelines for clinical nutrition. Edited by V.M. Luft. 3rd reprint. St. Petersburg: “Art Express”, 2016:275 p. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Руководство по клиническому питанию. Под ред. В.М. Луфта. 3-е переизд. СПб.: «Арт Экспресс», 2016:275 с. [Guidelines for clinical nutrition. Edited by V.M. Luft. 3rd reprint. St. Petersburg: “Art Express”, 2016:275 p. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">ГОСТ Р 56819-2015. Надлежащая медицинская практика. Инфологическая модель. Прифилактика пролежней. [GOST R 56819-2015. Good medical practice. Infological model. Prevention of bedsores. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">ГОСТ Р 56819-2015. Надлежащая медицинская практика. Инфологическая модель. Прифилактика пролежней. [GOST R 56819-2015. Good medical practice. Infological model. Prevention of bedsores. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">European Pressure Ulcer Advisory Panel, National Pressure Injury Advisory Panel and Pan Pacific Pressure Injury Alliance. Prevention and Treatment of Pressure Ulcers/I njuries: Clinical Practice Guideline. The International Guideline. EPUAP/NPIAP/PPPIA — 2019.</mixed-citation><mixed-citation xml:lang="en">European Pressure Ulcer Advisory Panel, National Pressure Injury Advisory Panel and Pan Pacific Pressure Injury Alliance. Prevention and Treatment of Pressure Ulcers/I njuries: Clinical Practice Guideline. The International Guideline. EPUAP/NPIAP/PPPIA — 2019.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Schols J.M.G.A., Heyman H., Meijer E.P. Nutritional support in the treatment and prevention of pressure ulcers: an overview of studies with an arginine enriched oral nutritional supplement. Journal of Tissue Viability. 2009;18(3):72–79. https://doi.org/10.1007/978-1-62703-700</mixed-citation><mixed-citation xml:lang="en">Schols J.M.G.A., Heyman H., Meijer E.P. Nutritional support in the treatment and prevention of pressure ulcers: an overview of studies with an arginine enriched oral nutritional supplement. Journal of Tissue Viability. 2009;18(3):72–79. https://doi.org/10.1007/978-1-62703-700</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Frías Soriano L., Lage Vázquez M.A., Pérez-Portabella Maristany C., Xandri Graupera J.M., Wouters-Wesseling W., Wagenaar L. The effectiveness of oral nutritional supplementation in the healing of pressure ulcers, J. Wound Care. 2004; 13(8): 319–322. https://doi.org/10.12968/jowc.2004.13.8.26654</mixed-citation><mixed-citation xml:lang="en">Frías Soriano L., Lage Vázquez M.A., Pérez-Portabella Maristany C., Xandri Graupera J.M., Wouters-Wesseling W., Wagenaar L. The effectiveness of oral nutritional supplementation in the healing of pressure ulcers, J. Wound Care. 2004; 13(8): 319–322. https://doi.org/10.12968/jowc.2004.13.8.26654</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Heyman H., Van De Looverbosch D.E.J., Meijer E.P., Schols M.G.A. Benefits of an oral nutritional supplement on pressure ulcer healing in long-term care residents. J. Wound Care. 2008;17:476–478(480). https://doi.org/10.12968/jowc.2008.17.11.31475</mixed-citation><mixed-citation xml:lang="en">Heyman H., Van De Looverbosch D.E.J., Meijer E.P., Schols M.G.A. Benefits of an oral nutritional supplement on pressure ulcer healing in long-term care residents. J. Wound Care. 2008;17:476–478(480). https://doi.org/10.12968/jowc.2008.17.11.31475</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Benati G., Delvecchio S., Cilla D., Pedone V. Impact on pressure ulcer healing of an arginine-enriched nutritional solution in patients with severe cognitive impairment. Arch. Gerontol. Geriatr. 2001;1:43–47. https://doi.org/10.1016/s0167-4943(01)00120-0</mixed-citation><mixed-citation xml:lang="en">Benati G., Delvecchio S., Cilla D., Pedone V. Impact on pressure ulcer healing of an arginine-enriched nutritional solution in patients with severe cognitive impairment. Arch. Gerontol. Geriatr. 2001;1:43–47. https://doi.org/10.1016/s0167-4943(01)00120-0</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Cereda E., Klersy C., Serioli M., Crespi A., Dándrea F. A Nutritional Formula Enriched With Arginine, Zinc, and Antioxidants for the Healing of Pressure Ulcers. Ann Intern Med. 2015;162:167–174. https://doi.org/10.7326 /m14-0696</mixed-citation><mixed-citation xml:lang="en">Cereda E., Klersy C., Serioli M., Crespi A., Dándrea F. A Nutritional Formula Enriched With Arginine, Zinc, and Antioxidants for the Healing of Pressure Ulcers. Ann Intern Med. 2015;162:167–174. https://doi.org/10.7326 /m14-0696</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Cereda E., Gini A.G., Pedrolli C., Alfredo A. Disease-specific, versus standard, nutritional support for the treatment of pressure ulcers in institutionalized older adults: a randomized controlled trial. J Am Geriatr Soc. 2009;57(8):1395–1402. https://doi.org/10.1111 / j.1532-5415.2009.02351.x</mixed-citation><mixed-citation xml:lang="en">Cereda E., Gini A.G., Pedrolli C., Alfredo A. Disease-specific, versus standard, nutritional support for the treatment of pressure ulcers in institutionalized older adults: a randomized controlled trial. J Am Geriatr Soc. 2009;57(8):1395–1402. https://doi.org/10.1111 / j.1532-5415.2009.02351.x</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Desneves K.J., Todorovic B.E., Cassar A., Crowe T.C. Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomized controlled trial. Clin. Nutr. 2005;24:979–987. https://doi.org/10.1016/j.clnu.2005.06.011</mixed-citation><mixed-citation xml:lang="en">Desneves K.J., Todorovic B.E., Cassar A., Crowe T.C. Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomized controlled trial. Clin. Nutr. 2005;24:979–987. https://doi.org/10.1016/j.clnu.2005.06.011</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">van Anholt R.D., Sobotka L., Meijer E.P., Heyman H., Groen H.W., Topinkova E, van Leen M., Schols J.M.G.A. Specific nutritional support accelerates pressure ulcer healing and reduces wound care intensity in non-malnourished patients. Nutrition. 2010;26:867–872. https://doi.org/10.1016/j.nut.2010.05.009</mixed-citation><mixed-citation xml:lang="en">van Anholt R.D., Sobotka L., Meijer E.P., Heyman H., Groen H.W., Topinkova E, van Leen M., Schols J.M.G.A. Specific nutritional support accelerates pressure ulcer healing and reduces wound care intensity in non-malnourished patients. Nutrition. 2010;26:867–872. https://doi.org/10.1016/j.nut.2010.05.009</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Brewer S., Desneves K., Pearce L.M., Mills K.J., Dunn L., Brown D., Crowe T. Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal cord patients. J. Wound Care. 2010;19(7):311–316. https://doi.org/10.12968/jowc.2012.21.3.150</mixed-citation><mixed-citation xml:lang="en">Brewer S., Desneves K., Pearce L.M., Mills K.J., Dunn L., Brown D., Crowe T. Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal cord patients. J. Wound Care. 2010;19(7):311–316. https://doi.org/10.12968/jowc.2012.21.3.150</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Chapman B.R., Mills K.J., Pearce L.M., Crowe T.C. Use of an arginine-enriched oral nutritional supplement in the healing of pressure ulcers in patients with spinal cord injuries: an observational study. Nutr. Dietetics. 2011;68(3):208–213. https://doi.org/10.1007/978-1-4471-7413-4_4</mixed-citation><mixed-citation xml:lang="en">Chapman B.R., Mills K.J., Pearce L.M., Crowe T.C. Use of an arginine-enriched oral nutritional supplement in the healing of pressure ulcers in patients with spinal cord injuries: an observational study. Nutr. Dietetics. 2011;68(3):208–213. https://doi.org/10.1007/978-1-4471-7413-4_4</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Leigh B., Desneves K., Rafferty J., Pearce L.M., King S., Woodward M.C., Brown D. The effect of different doses of an arginine-containing supplement on the healing of pressure ulcers. J. Wound Care. 2012;31(3):150–156. https://doi.org/10.12968/jowc.2012.21.3.150</mixed-citation><mixed-citation xml:lang="en">Leigh B., Desneves K., Rafferty J., Pearce L.M., King S., Woodward M.C., Brown D. The effect of different doses of an arginine-containing supplement on the healing of pressure ulcers. J. Wound Care. 2012;31(3):150–156. https://doi.org/10.12968/jowc.2012.21.3.150</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Wong A., Chew A., Wang C.M., Ong L., Zhang S.H. The use of a specialised amino acid mixture for pressure ulcers: a placebocontrolled trial. J. Wound Care. 2014;23(5):259–269. https://doi.org/10.1016/j.jnim.2017.05.001</mixed-citation><mixed-citation xml:lang="en">Wong A., Chew A., Wang C.M., Ong L., Zhang S.H. The use of a specialised amino acid mixture for pressure ulcers: a placebocontrolled trial. J. Wound Care. 2014;23(5):259–269. https://doi.org/10.1016/j.jnim.2017.05.001</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Невзорова Д.В. Результаты многоцентрового рандомизированного пострегистрационного сравнительного исследования нутризон эдванст кубизон в комплексном лечении пролежней в сравнении со стандартным зондовым питанием. [Nevzorova D.V. Results of a multicenter randomized postregistration comparative study of nutrizon advanst kubizon in the complex treatment of bedsores in comparison with standard probe nutrition. (In Russ.)]. https://b-com.mci-group.com/EventProgramme/ESPEN2022.aspx</mixed-citation><mixed-citation xml:lang="en">Невзорова Д.В. Результаты многоцентрового рандомизированного пострегистрационного сравнительного исследования нутризон эдванст кубизон в комплексном лечении пролежней в сравнении со стандартным зондовым питанием. [Nevzorova D.V. Results of a multicenter randomized postregistration comparative study of nutrizon advanst kubizon in the complex treatment of bedsores in comparison with standard probe nutrition. (In Russ.)]. https://b-com.mci-group.com/EventProgramme/ESPEN2022.aspx</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
