r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2022-27-5-14-22r-n-j-355Research ArticleОБЗОРЫREVIEWSСовременный взгляд на проблему синкинезий у пациентов с невропатией лицевого нерваSynkinesis in patients with neuropathy of the facial nervehttps://orcid.org/0000-0003-2763-0320ЧехонацкаяК. И.ChekhonatskayaK. Ig.

 г. Красногорск 

  Krasnogorsk 

https://orcid.org/0000-0002-8572-7094ЗавалийЛ. Б.ZavaliyL. B.

  Москва 

 Moscow 

ZavaliyLB@sklif.mos.ruhttps://orcid.org/0000-0001-6824-4114РамазановГ. Р.RamazanovG. R.

  Москва 

 Moscow 

https://orcid.org/0000-0001-5026-0060СинкинМ. В.SinkinM. V.

  Москва 

 Moscow 

https://orcid.org/0000-0003-1691-9516СалиховК. С.SalikhovK. S.

  Москва

 Moscow 

https://orcid.org/0000-0003-1141-2919ПетриковС. С.PetrikovS. S.

Москва

 Moscow 

АО Ильинская больницаРоссияJSC Ilyinskaya HospitalRussian FederationГБУЗ Научно-исследовательский институт скорой помощи им. Н.В. СклифосовскогоРоссияN.V. Sklifosovskii Research Institute of Emergency Medical CareRussian FederationФГБУ НМИЦ Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии Минздрава РоссииРоссияCentral Research Institute of Dentistry and Maxillofacial SurgeryRussian FederationГБУЗ Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского; ФГБОУ ВО Московский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияN.V. Sklifosovskii Research Institute of Emergency Medical Care; A.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation2022231120222751422Copyright © Чехонацкая К.И., Завалий Л.Б., Рамазанов Г.Р., Синкин М.В., Салихов К.С., Петриков С.С., 20222022Чехонацкая К.И., Завалий Л.Б., Рамазанов Г.Р., Синкин М.В., Салихов К.С., Петриков С.С.Chekhonatskaya K.I., Zavaliy L.B., Ramazanov G.R., Sinkin M.V., Salikhov K.S., Petrikov S.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/355

Лицевые синкинезии представляют собой непроизвольные сокращения мимических мышц, возникающие во время осуществления ими произвольного движения. Представлен обзор литературы по проблеме патологических синкинезий как осложнения невропатии лицевого нерва. Описан механизм их развития и основные теории возникновения. Данный вопрос по настоящее время вызывает дискуссии. Информация о частоте развития синкинезий в литературе также противоречива. Описаны виды (паттерны) синкинезий, методы их выявления, клиническая характеристика. Рассмотрены основные виды консервативного и оперативного лечения, реабилитация.

Facial synkinesis is involuntary contractions of unrelated groups of facial muscles that occur during voluntary movement. The article presents a review of scientific literature of the problem pathological synkinesis as a complication of facial neuropathy. The mechanism of their development and the main theories of occurrence are described. We describе the types (patterns) of synkinesis, methods for theirs detecting, description of clinical manifestations, methods of instrumental diagnostics. We reviewed approaches to treatment and rehabilitation, the main types of conservative and surgical treatment.

синкинезияпостпаралитический гемиспазмневропатия лицевого нервапаралич Беллаботулинический токсин типа Ахирургическое лечение синкинезийsynkinesissynkinesiafacial synkinesispostparalytic hemispasmfacial neuropathyBell’s palsybotulinum toxin type Asurgical treatment of synkinesisReferencesShokri T., Patel S., Ziai K., Harounian J., Lighthall J.G. Facial synkinesis: A distressing sequela of facial palsy. Ear Nose Throat J. 2021:1455613211054627. https://doi.org/10.1177/01455613211054627Shokri T., Patel S., Ziai K., Harounian J., Lighthall J.G. Facial synkinesis: A distressing sequela of facial palsy. Ear Nose Throat J. 2021:1455613211054627. https://doi.org/10.1177/01455613211054627Рахманина А.А., Калантарова М.В., Холмогорова А.Б., Завалий Л.Б. Переживание болезни и эмоциональное неблагополучие при невропатии лицевого нерва. В кн.: Консультативная психология: вызовы практики: Москва: ФБГНУ «Психологический институт РАО», 2020:211–212. [Rakhmanina A.A., Kalantarova M.V., Kholmogorova A.B., Zavaliĭ L.B. Experiencing illness and emotional distress in neuropathy of the facial nerve. In: Konsul’tativnaya psikhologiya: vyzovy praktiki: Moscow: FBGNU «Psikhologicheskiĭ institut RAO», 2020:211–212. (In Russ.)].Рахманина А.А., Калантарова М.В., Холмогорова А.Б., Завалий Л.Б. Переживание болезни и эмоциональное неблагополучие при невропатии лицевого нерва. В кн.: Консультативная психология: вызовы практики: Москва: ФБГНУ «Психологический институт РАО», 2020:211–212. [Rakhmanina A.A., Kalantarova M.V., Kholmogorova A.B., Zavaliĭ L.B. Experiencing illness and emotional distress in neuropathy of the facial nerve. In: Konsul’tativnaya psikhologiya: vyzovy praktiki: Moscow: FBGNU «Psikhologicheskiĭ institut RAO», 2020:211–212. (In Russ.)].Калантарова М.В., Рахманина А.А., Холмогорова А.Б., Завалий Л.Б. Проблема эмоциональной дезадаптации при невропатии лицевого нерва. В кн.: Зейгарниковские чтения. Диагностика и психологическая помощь в современной клинической психологии: проблема научных и этических оснований. Москва: 2020:697–700. [Kalantarova M.V., Rakhmanina A.A., Kholmogorova A.B., Zavaliy L.B. The problem of emotional maladjustment in neuropathy of the facial nerve. In: Zeygarnikovskie chteniya. Diagnostika i psikhologicheskaya pomoshch’ v sovremennoy klinicheskoy psikhologii: problema nauchnykh i eticheskikh osnovaniy. Moscow: 2020:697–700. (In Russ.)].Калантарова М.В., Рахманина А.А., Холмогорова А.Б., Завалий Л.Б. Проблема эмоциональной дезадаптации при невропатии лицевого нерва. В кн.: Зейгарниковские чтения. Диагностика и психологическая помощь в современной клинической психологии: проблема научных и этических оснований. Москва: 2020:697–700. [Kalantarova M.V., Rakhmanina A.A., Kholmogorova A.B., Zavaliy L.B. The problem of emotional maladjustment in neuropathy of the facial nerve. In: Zeygarnikovskie chteniya. Diagnostika i psikhologicheskaya pomoshch’ v sovremennoy klinicheskoy psikhologii: problema nauchnykh i eticheskikh osnovaniy. Moscow: 2020:697–700. (In Russ.)].Fowler E.P. Jr., Edmund P. Abnormal movements following injury to the facial nerve. J Amer Med. 1939;113(11):1003–1008. https://doi.org/10.1001/jama.1939.02800360017006Fowler E.P. Jr., Edmund P. Abnormal movements following injury to the facial nerve. J Amer Med. 1939;113(11):1003–1008. https://doi.org/10.1001/jama.1939.02800360017006Богорад Ф.А. Синдром «крокодильих» слез. Лечебное дело. 1928;(17):1328–1330. [Bogorad F.A. Sindrom «krokodil’ikh» slez. Lechebnoe delo. 1928;(17):1328–1330. (In Russ.)].Богорад Ф.А. Синдром «крокодильих» слез. Лечебное дело. 1928;(17):1328–1330. [Bogorad F.A. Sindrom «krokodil’ikh» slez. Lechebnoe delo. 1928;(17):1328–1330. (In Russ.)].Kroll M. Syndrome der Reflexstorungen. In: Die Neuropathologischen Syndrom. Zugleich Differialdiagnostik der Nervenkrankheiten. Berlin, Heidelberg: Springer; 1929:222. https://link.springer.com/chapter/10.1007/978-3-642-91845-2_4Kroll M. Syndrome der Reflexstorungen. In: Die Neuropathologischen Syndrom. Zugleich Differialdiagnostik der Nervenkrankheiten. Berlin, Heidelberg: Springer; 1929:222. https://link.springer.com/chapter/10.1007/978-3-642-91845-2_4Kaminsky S.D. Ueber das Syndrom der Krokodilstranen. Deutsche Ztschr fuir Nervenh. 1929;110:151.Kaminsky S.D. Ueber das Syndrom der Krokodilstranen. Deutsche Ztschr fuir Nervenh. 1929;110:151.Ford R.F. Paroxysmal Lacrimation During Eating as a Sequel of Facial Palsy (Syndrome of Crocodile Tears); Report of Four Cases with Possible Interpretation and Comparison with Auriculotemporal Syndrome. Arch Neurol Psychiat. 1933;29(6):1279–1288. https://doi.org/10.1001/archneurpsyc.1933.02240120102008Ford R.F. Paroxysmal Lacrimation During Eating as a Sequel of Facial Palsy (Syndrome of Crocodile Tears); Report of Four Cases with Possible Interpretation and Comparison with Auriculotemporal Syndrome. Arch Neurol Psychiat. 1933;29(6):1279–1288. https://doi.org/10.1001/archneurpsyc.1933.02240120102008Sunderland S. Nerve and Nerve Injuries. 2nd ed. London, UK: Churchill Livingstone;1978:88–97.Sunderland S. Nerve and Nerve Injuries. 2nd ed. London, UK: Churchill Livingstone;1978:88–97.Mav M. Anatomy of the Facial Nerve. Laryngoscope. 1973;83(8):1311–1329. https://doi.org/10.1288/00005537-197308000-00015Mav M. Anatomy of the Facial Nerve. Laryngoscope. 1973;83(8):1311–1329. https://doi.org/10.1288/00005537-197308000-00015Baker R.S., Stava M.W., Nelson K.R., May P.J., Huffman M.D., Porter J.D. Aberrant reinnervation of facial musculature in a subhuman primate: a correlative analysis of eyelid kinematics, muscle synkinesis, and motoneuron localization. Neurology. 1994;44(11):2165–2173. https://doi.org/10/1212/WNL.44.11.2165Baker R.S., Stava M.W., Nelson K.R., May P.J., Huffman M.D., Porter J.D. Aberrant reinnervation of facial musculature in a subhuman primate: a correlative analysis of eyelid kinematics, muscle synkinesis, and motoneuron localization. Neurology. 1994;44(11):2165–2173. https://doi.org/10/1212/WNL.44.11.2165Yamada H., Hato N., Murakami S., Honda N., Wakisaka H., Takahashi H. et al. Facial synkinesis after experimental compression of the facial nerve comparing intratemporal and extratemporal lesions. Laryngoscope. 2010;120(5):1022–1027. https://doi.org/10.1002/lary.20840Yamada H., Hato N., Murakami S., Honda N., Wakisaka H., Takahashi H. et al. Facial synkinesis after experimental compression of the facial nerve comparing intratemporal and extratemporal lesions. Laryngoscope. 2010;120(5):1022–1027. https://doi.org/10.1002/lary.20840Montserrat L., Benito M. Facial synkinesis and aberrant regeneration of facial nerve. Adv Neurol. 1988;49:211–24. PMID: 3278542Montserrat L., Benito M. Facial synkinesis and aberrant regeneration of facial nerve. Adv Neurol. 1988;49:211–24. PMID: 3278542Choi D., Raisman G. Somatotopic organization of the facial nucleus is disrupted after lesioning and regeneration of the facial nerve: the histological representation of synkinesis. Neurosurgery. 2002;50(2):355–362; discussion 362–363. https://doi.org/10.1097/00006123-200202000-00022Choi D., Raisman G. Somatotopic organization of the facial nucleus is disrupted after lesioning and regeneration of the facial nerve: the histological representation of synkinesis. Neurosurgery. 2002;50(2):355–362; discussion 362–363. https://doi.org/10.1097/00006123-200202000-00022Oge A.E., Yayla V., Demir G.A., Eraksoy M. Excitability of facial nucleus and related brain-stem reflexes in hemifacial spasm, post-facial palsy synkinesis and facial myokymia. Clin Neurophysiol. 2005;116(7):1542–1554. https://doi.org/10.1016/j.clinph.2005.02.021Oge A.E., Yayla V., Demir G.A., Eraksoy M. Excitability of facial nucleus and related brain-stem reflexes in hemifacial spasm, post-facial palsy synkinesis and facial myokymia. Clin Neurophysiol. 2005;116(7):1542–1554. https://doi.org/10.1016/j.clinph.2005.02.021Ma J., Hua X.Y., Zheng M.X., Wu J.J., Huo B.B., Xing X.X. et al. Spatial patterns of intrinsic brain activity and functional connectivity in facial synkinesis patients. Br J Neurosurg. 2021;35(6):730–735. https://doi.org/10.1080/02688697.2020.1773396Ma J., Hua X.Y., Zheng M.X., Wu J.J., Huo B.B., Xing X.X. et al. Spatial patterns of intrinsic brain activity and functional connectivity in facial synkinesis patients. Br J Neurosurg. 2021;35(6):730–735. https://doi.org/10.1080/02688697.2020.1773396Wang Y., Yang L., Wang W.W., Ding W., Liu H.Q. Decreased Distance between Representation Sites of Distinct Facial Movements in Facial Synkinesis-A Task fMRI Study. Neuroscience. 2019;397:12–17. https://doi.org/10.1016/j.neuroscience.2018.11.036Wang Y., Yang L., Wang W.W., Ding W., Liu H.Q. Decreased Distance between Representation Sites of Distinct Facial Movements in Facial Synkinesis-A Task fMRI Study. Neuroscience. 2019;397:12–17. https://doi.org/10.1016/j.neuroscience.2018.11.036Ton Van C., Giot J.P. Synkinesis in facial palsy: What do we know about the physiopathology? Ann Chir Plast Esthet. 2021;66(5):371–378. https://doi.org/10.1016/j.anplas.2021.03.008Ton Van C., Giot J.P. Synkinesis in facial palsy: What do we know about the physiopathology? Ann Chir Plast Esthet. 2021;66(5):371–378. https://doi.org/10.1016/j.anplas.2021.03.008Crumley R.L. Mechanisms of synkinesis. Laryngoscope. 1979;89(11):1847–1854. https://doi.org/10.1288/00005537-197911000-00020Crumley R.L. Mechanisms of synkinesis. Laryngoscope. 1979;89(11):1847–1854. https://doi.org/10.1288/00005537-197911000-00020Celik M., Forta H., Vural C. The development of synkinesis after facial nerve paralysis. Eur Neurol. 2000;43(3):147–151. https://doi.org/10.1159/000008154Celik M., Forta H., Vural C. The development of synkinesis after facial nerve paralysis. Eur Neurol. 2000;43(3):147–151. https://doi.org/10.1159/000008154Husseman J., Mehta R.P. Management of synkinesis. Facial Plast Surg. 2008;24(2):242–249. https://doi.org/10.1055/s-2008-1075840Husseman J., Mehta R.P. Management of synkinesis. Facial Plast Surg. 2008;24(2):242–249. https://doi.org/10.1055/s-2008-1075840Завалий Л.Б., Рамазанов Г.Р., Чехонацкая К.И., Синкин М.В., Селиверстова Е.Г., Семенов Л.Л., и др. Комплексный подход к диагностике, лечению и реабилитации пациентов с невропатией лицевого нерва в разные периоды заболевания. Российский неврологический журнал. 2022;27(1):69–79. [Zavaliy L.B., Ramazanov G.R., Chekhonatskaya K.I., Sinkin M.V., Seliverstova E.G., Semenov L.L. et al. Comprehensive approach to the diagnosis, treatment and rehabilitation of patients with facial nerve neuropathy at different periods of the disease. Russian neurological journal. 2022;27(1):69–79. (In Russ.)]. https://doi.org/10.30629/2658-7947-2022-27-1-69-79Завалий Л.Б., Рамазанов Г.Р., Чехонацкая К.И., Синкин М.В., Селиверстова Е.Г., Семенов Л.Л., и др. Комплексный подход к диагностике, лечению и реабилитации пациентов с невропатией лицевого нерва в разные периоды заболевания. Российский неврологический журнал. 2022;27(1):69–79. [Zavaliy L.B., Ramazanov G.R., Chekhonatskaya K.I., Sinkin M.V., Seliverstova E.G., Semenov L.L. et al. Comprehensive approach to the diagnosis, treatment and rehabilitation of patients with facial nerve neuropathy at different periods of the disease. Russian neurological journal. 2022;27(1):69–79. (In Russ.)]. https://doi.org/10.30629/2658-7947-2022-27-1-69-79Wu Z.B., Silverman C.A., Linstrom C.J., Tesseman B., Cosetti M.K. Objective computerized versus subjective analysis of facial synkinesis. Laryngoscope. 2005;115(12):2118Y22. https://doi.org/10.1097/01.mlg.0000182811.49686.76Wu Z.B., Silverman C.A., Linstrom C.J., Tesseman B., Cosetti M.K. Objective computerized versus subjective analysis of facial synkinesis. Laryngoscope. 2005;115(12):2118Y22. https://doi.org/10.1097/01.mlg.0000182811.49686.76Maria C.M., Kim J. Individualized management of facial synkinesis based on facial function. Acta Otolaryngol. 2017;137(9):1010–1015. https://doi.org/10.1080/00016489.2017.1316871Maria C.M., Kim J. Individualized management of facial synkinesis based on facial function. Acta Otolaryngol. 2017;137(9):1010–1015. https://doi.org/10.1080/00016489.2017.1316871Beurskens C.H.G., Oosterhof J. Nijhuis-van der Sanden MWG. Frequency and location of synkineses in patients with peripheralfacial nerve paresis. Otol Neurotol. 2010;31(4):671–675. https://doi.org/10.1097/MAO.0b013e3181d8d84dBeurskens C.H.G., Oosterhof J. Nijhuis-van der Sanden MWG. Frequency and location of synkineses in patients with peripheralfacial nerve paresis. Otol Neurotol. 2010;31(4):671–675. https://doi.org/10.1097/MAO.0b013e3181d8d84dMoran C.J., Neely J.G. Patterns of facial nerve synkinesis. Laryngoscope. 1996;106(12Pt1):1491–1496. https://doi.org/10.1097/00005537-199612000-00009Moran C.J., Neely J.G. Patterns of facial nerve synkinesis. Laryngoscope. 1996;106(12Pt1):1491–1496. https://doi.org/10.1097/00005537-199612000-00009Bajaj-Luthra A., Van Swearingen J., Thornton R.H., Johnson P.C. Quantitation of patterns of facial movement in patients with ocular to oral synkinesis. Plast Reconstr Surg. 1998;101(6):1473–1480. https://doi.org/10.1097/00006534-199805000-00007Bajaj-Luthra A., Van Swearingen J., Thornton R.H., Johnson P.C. Quantitation of patterns of facial movement in patients with ocular to oral synkinesis. Plast Reconstr Surg. 1998;101(6):1473–1480. https://doi.org/10.1097/00006534-199805000-00007Williams T., Tungland B., Stobbs N., Watson G. Oculostapedial synkinesis following idiopathic facial palsy: something to listen out for. J Laryngol Otol. 2018;132(8):757–758. https://doi.org/10.1017/S0022215118001147Williams T., Tungland B., Stobbs N., Watson G. Oculostapedial synkinesis following idiopathic facial palsy: something to listen out for. J Laryngol Otol. 2018;132(8):757–758. https://doi.org/10.1017/S0022215118001147Brichacek M.A., Brandt M.G., Carey J.P., Byrne P.J. Stapedial synkinesis causing change in hearing threshold with facial motion. Otol Neurotol. 2013;34(4):762–765. https://doi.org/10.1097/MAO.0b013e31827f1909Brichacek M.A., Brandt M.G., Carey J.P., Byrne P.J. Stapedial synkinesis causing change in hearing threshold with facial motion. Otol Neurotol. 2013;34(4):762–765. https://doi.org/10.1097/MAO.0b013e31827f1909Bahk S., Hwang S., Eo S. Idiopathic Synkinesis of the Facial Musculature: Oculo-Nasal, Oculo-Zygomatic, and Fronto-Nasal Synkinesis. J Craniofac Surg. 2017;28(1):e61–e64. https://doi.org/10.1097/SCS.0000000000003214Bahk S., Hwang S., Eo S. Idiopathic Synkinesis of the Facial Musculature: Oculo-Nasal, Oculo-Zygomatic, and Fronto-Nasal Synkinesis. J Craniofac Surg. 2017;28(1):e61–e64. https://doi.org/10.1097/SCS.0000000000003214Ma M.S., van der Hoeven J.H., Nicolai J.P., Meek M.F. Soundinduced facial synkinesis following facial nerve paralysis. J Plast Reconstr Aesthet Surg. 2009;62(8):1025–1029. https://doi.org/10.1016/j.bjps.2007.12.049Ma M.S., van der Hoeven J.H., Nicolai J.P., Meek M.F. Soundinduced facial synkinesis following facial nerve paralysis. J Plast Reconstr Aesthet Surg. 2009;62(8):1025–1029. https://doi.org/10.1016/j.bjps.2007.12.049Jacome D.E. Catamenial synkinetic retroauricular pain. Cephalalgia. 2003;23(3):214–217. https://doi.org/10.1046/j.1468-2982.2003.00483.xJacome D.E. Catamenial synkinetic retroauricular pain. Cephalalgia. 2003;23(3):214–217. https://doi.org/10.1046/j.1468-2982.2003.00483.xGrauer J.S., Shapiro S.Z., Ostrower S.T. Cochlear Implantation and Facial Nerve Synkinesis in an Infant with Hypoplastic Internal Auditory Canals — A Case Report. Cureus. 2019;11(8):e5420. https://doi.org/10.7759/cureus.5420Grauer J.S., Shapiro S.Z., Ostrower S.T. Cochlear Implantation and Facial Nerve Synkinesis in an Infant with Hypoplastic Internal Auditory Canals — A Case Report. Cureus. 2019;11(8):e5420. https://doi.org/10.7759/cureus.5420Jethani J. Marin-Amat syndrome: a rare facial synkinesis. Indian J Ophthalmol. 2007;55(5):402–403. https://doi.org/10.4103/0301-4738.33842Jethani J. Marin-Amat syndrome: a rare facial synkinesis. Indian J Ophthalmol. 2007;55(5):402–403. https://doi.org/10.4103/0301-4738.33842Sinis N., Horn F., Genchev B., Skouras E., Merkel D., Angelova S.K. et al. Electrical stimulation of paralyzed vibrissal muscles reduces endplate reinnervation and does not promote motor recovery after facial nerve repair in rats. Ann Anat. 2009;191(4):356–370. https://doi.org/10.1016/j.aanat.2009.03.004Sinis N., Horn F., Genchev B., Skouras E., Merkel D., Angelova S.K. et al. Electrical stimulation of paralyzed vibrissal muscles reduces endplate reinnervation and does not promote motor recovery after facial nerve repair in rats. Ann Anat. 2009;191(4):356–370. https://doi.org/10.1016/j.aanat.2009.03.004Mehta R.P., WernickRobinson M., Hadlock T.A. Validation of the Synkinesis Assessment Questionnaire. Laryngoscope. 2007;117(5):923–926. https://doi.org/10.1097/MLG.0b013e3180412460Mehta R.P., WernickRobinson M., Hadlock T.A. Validation of the Synkinesis Assessment Questionnaire. Laryngoscope. 2007;117(5):923–926. https://doi.org/10.1097/MLG.0b013e3180412460Krane N.A., Genther D., Weierich K., Hanseler H., Liu S.W., Mowery A. et al. Degree of Self-Reported Facial Impairment Correlates with Social Impairment in Individuals with Facial Paralysis and Synkinesis. Facial Plast Surg Aesthet Med. 2020; May 14. https://doi.org/10.1089/fpsam.2020.0082 Online ahead of print.Krane N.A., Genther D., Weierich K., Hanseler H., Liu S.W., Mowery A. et al. Degree of Self-Reported Facial Impairment Correlates with Social Impairment in Individuals with Facial Paralysis and Synkinesis. Facial Plast Surg Aesthet Med. 2020; May 14. https://doi.org/10.1089/fpsam.2020.0082 Online ahead of print.Cabrol C., Elarouti L., Montava A.L., Jarze S., Mancini J., Lavieille J.P. et al. Sunnybrook Facial Grading System: Intra-rater and Inter-rater Variabilities. Otol Neurotol. 2021;42(7):1089–1094. https://doi.org/10.1097/MAO.0000000000003140Cabrol C., Elarouti L., Montava A.L., Jarze S., Mancini J., Lavieille J.P. et al. Sunnybrook Facial Grading System: Intra-rater and Inter-rater Variabilities. Otol Neurotol. 2021;42(7):1089–1094. https://doi.org/10.1097/MAO.0000000000003140Waubant A., Franco-Vidal V., Ribadeau Dumas A. Validation of a French version of the Sunnybrook facial grading system. Eur Ann Otorhinolaryngol Head Neck Dis. 2022:139(3):119–124. https://doi.org/10.1016/j.anorl.2021.08.003Waubant A., Franco-Vidal V., Ribadeau Dumas A. Validation of a French version of the Sunnybrook facial grading system. Eur Ann Otorhinolaryngol Head Neck Dis. 2022:139(3):119–124. https://doi.org/10.1016/j.anorl.2021.08.003Banks C.A., Jowett N., Azizzadeh B., Beurskens C., Bhama P., Borschel G. et al. Worldwide Testing of the eFACE Facial Nerve Clinician-Graded Scale. Plast Reconstr Surg. 2017;139(2):491e–498e. https://doi.org/10.1097/PRS.0000000000002954Banks C.A., Jowett N., Azizzadeh B., Beurskens C., Bhama P., Borschel G. et al. Worldwide Testing of the eFACE Facial Nerve Clinician-Graded Scale. Plast Reconstr Surg. 2017;139(2):491e–498e. https://doi.org/10.1097/PRS.0000000000002954Banks C.A., Bhama P.K., Park J., Hadlock C.R., Hadlock T.A. Clinician-Graded Electronic Facial Paralysis Assessment: The eFACE. Plast Reconstr Surg. 2015;136(2):223e–230e. https://doi.org/10.1097/PRS.0000000000001447Banks C.A., Bhama P.K., Park J., Hadlock C.R., Hadlock T.A. Clinician-Graded Electronic Facial Paralysis Assessment: The eFACE. Plast Reconstr Surg. 2015;136(2):223e–230e. https://doi.org/10.1097/PRS.0000000000001447Azuma T., Nakamura K., Takahashi M., Miyoshi H., Toda N., Iwasaki H. et al. Electroneurography cannot predict when facial synkinesis develops in patients with facial palsy. J Med Invest. 2020;67(1.2):87–89. https://doi.org/10.2152/jmi.67.87Azuma T., Nakamura K., Takahashi M., Miyoshi H., Toda N., Iwasaki H. et al. Electroneurography cannot predict when facial synkinesis develops in patients with facial palsy. J Med Invest. 2020;67(1.2):87–89. https://doi.org/10.2152/jmi.67.87Azuma T., Nakamura K., Takahashi M., Miyoshi H., Toda N., Iwasaki H. et al. Auris Electroneurography in the acute stage of facial palsy as a predictive factor for the development of facial synkinesis sequela. Nasus Larynx. 2018;45(4):728–731. https://doi.org/10.1016/j.anl.2017.09.016Azuma T., Nakamura K., Takahashi M., Miyoshi H., Toda N., Iwasaki H. et al. Auris Electroneurography in the acute stage of facial palsy as a predictive factor for the development of facial synkinesis sequela. Nasus Larynx. 2018;45(4):728–731. https://doi.org/10.1016/j.anl.2017.09.016Kanaya K., Ushio M., Kondo K., Hagisawa M., Suzukawa K., Yamaguchi T. et al. Recovery of facial movement and facial synkinesis in Bell’s –644. https://doi.org/10.1097/MAO.0b013e3181ab31afKanaya K., Ushio M., Kondo K., Hagisawa M., Suzukawa K., Yamaguchi T. et al. Recovery of facial movement and facial synkinesis in Bell’s –644. https://doi.org/10.1097/MAO.0b013e3181ab31afOge A.E., Yazici J., Boyaciyan A., Tanyeri S., Celik M.,Konyalioğlu R. et al. Magnetic stimulation in hemifacial spasmand post-facial palsy synkinesis. Muscle Nerve. 1993;16(11):1154–1160. https://doi.org/10.1002/mus.880161103Oge A.E., Yazici J., Boyaciyan A., Tanyeri S., Celik M.,Konyalioğlu R. et al. Magnetic stimulation in hemifacial spasmand post-facial palsy synkinesis. Muscle Nerve. 1993;16(11):1154–1160. https://doi.org/10.1002/mus.880161103Kimura J., Rodnitzky R.L., Okawara S. Electrophysiological analysis of aberrant regeneration after facial nerve paralysis. Neurology. 1975;25(10):989–993. https://doi.org/10.1212/wnl.25.10.989Kimura J., Rodnitzky R.L., Okawara S. Electrophysiological analysis of aberrant regeneration after facial nerve paralysis. Neurology. 1975;25(10):989–993. https://doi.org/10.1212/wnl.25.10.989Pashov A., Pashova O. Facial synkinesis in patients with longstanding Bell’s palsy is a reversible consequence of disruption of reciprocal inhibition caused by prolonged absence of proprioceptive feedback. J Neurol Sci. 2019;405(Suppl):94–96. https://doi.org/10.1016/j.jns.2019.10.396Pashov A., Pashova O. Facial synkinesis in patients with longstanding Bell’s palsy is a reversible consequence of disruption of reciprocal inhibition caused by prolonged absence of proprioceptive feedback. J Neurol Sci. 2019;405(Suppl):94–96. https://doi.org/10.1016/j.jns.2019.10.396Balogh B., Frühwald F., Millesi W., Millesi H., Firbas W. Sonoanatomy of the muscles of facial expression. Surg Radiol Anat. 1988;10(2):101–106. https://doi.org/10.1007/BF02307817Balogh B., Frühwald F., Millesi W., Millesi H., Firbas W. Sonoanatomy of the muscles of facial expression. Surg Radiol Anat. 1988;10(2):101–106. https://doi.org/10.1007/BF02307817Volk G.F., Pohlmann M., Finkensieper M., Chalmers H.J., Guntinas-Lichius O. 3D-Ultrasonography for evaluation of facial muscles in patients with chronic facial palsy or defective healing: a pilot study. BMC Ear Nose Throat Disord. 2014;14:4. https://doi.org/10.1186/1472-6815-14-4 eCollection 2014Volk G.F., Pohlmann M., Finkensieper M., Chalmers H.J., Guntinas-Lichius O. 3D-Ultrasonography for evaluation of facial muscles in patients with chronic facial palsy or defective healing: a pilot study. BMC Ear Nose Throat Disord. 2014;14:4. https://doi.org/10.1186/1472-6815-14-4 eCollection 2014Farrugia M.E., Bydder G.M., Francis J.M., Robson M.D. Magnetic resonance imaging of facial muscles. Clin Radiol. 2007;62(11):1078–1086. https://doi.org/10.1016/j.crad.2007.05.003Farrugia M.E., Bydder G.M., Francis J.M., Robson M.D. Magnetic resonance imaging of facial muscles. Clin Radiol. 2007;62(11):1078–1086. https://doi.org/10.1016/j.crad.2007.05.003Roggenkamper P., Laskawi R., Damenz W., Schroder M., Nussgens Z. Botulinum toxin treatment of synkinesis following facial paralysis. HNO. 1990;38(8):295–297. PMID: 2228744Roggenkamper P., Laskawi R., Damenz W., Schroder M., Nussgens Z. Botulinum toxin treatment of synkinesis following facial paralysis. HNO. 1990;38(8):295–297. PMID: 2228744Borodic G., Bartley M., Slattery W., Glasscock M., Johnson E., Malazio C. et al. Botulinum toxin for aberrant facial nerve regeneration: double blind, placebo-controlled trial using subjective endpoints. Plast Reconstr Surg. 2005;116(1):36–43. https://doi.org/10.1097/01.prs.0000169689.27829.c4Borodic G., Bartley M., Slattery W., Glasscock M., Johnson E., Malazio C. et al. Botulinum toxin for aberrant facial nerve regeneration: double blind, placebo-controlled trial using subjective endpoints. Plast Reconstr Surg. 2005;116(1):36–43. https://doi.org/10.1097/01.prs.0000169689.27829.c4Завалий Л.Б., Петриков С.С., Рамазанов Г.Р., Чехонацкая К.И. Ботулинотерапия при невропатии лицевого нерва. Российский неврологический журнал. 2020;25(1):23–28. [Zavaliy L.B., Petrikov S.S., Ramazanov G.R., Chekhonatskaya K.I. Botulinum Therapy in Facial Nerve Neuropathy. Russian neurological journal. 2020;25(1):23–28. (In Russ.)]. https://doi.org/10.30629/2658-7947-2020-25-1-23-28Завалий Л.Б., Петриков С.С., Рамазанов Г.Р., Чехонацкая К.И. Ботулинотерапия при невропатии лицевого нерва. Российский неврологический журнал. 2020;25(1):23–28. [Zavaliy L.B., Petrikov S.S., Ramazanov G.R., Chekhonatskaya K.I. Botulinum Therapy in Facial Nerve Neuropathy. Russian neurological journal. 2020;25(1):23–28. (In Russ.)]. https://doi.org/10.30629/2658-7947-2020-25-1-23-28Акулов М.А., Орлова О.Р., Орлова А.С. Коррекция функции мимической мускулатуры после поражения лицевого нерва в остром и отдаленном периодах. РМЖ. Русский медицинский журнал. 2016;(14):902–906. [Akulov M.A., Orlova O.R., Orlova A.S. Correction of mimic muscles function after facial nerve lesions in acute and follow-up periods. RMJ. Russian medical journal. 2016;(14):902–906. (In Russ.)].Акулов М.А., Орлова О.Р., Орлова А.С. Коррекция функции мимической мускулатуры после поражения лицевого нерва в остром и отдаленном периодах. РМЖ. Русский медицинский журнал. 2016;(14):902–906. [Akulov M.A., Orlova O.R., Orlova A.S. Correction of mimic muscles function after facial nerve lesions in acute and follow-up periods. RMJ. Russian medical journal. 2016;(14):902–906. (In Russ.)].Чехонацкая К.И., Завалий Л.Б., Синкин М.В., Семенов Л.Л., Рамазанов Г.Р., Петриков С.С. Клинический случай восстановления функции мимических мышц у пациента с идиопатическим поражением лицевого нерва при неблагоприятных миографических предикторах. Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2021;10(1):216–223. [Chekhonatskaya K.I., Zavaliy L.B., Sinkin M.V., Semenov L.L., Ramazanov G.R., Petrikov S.S. Clinical Case of Facial Muscles Function Recovery in a Patient with Idiopathic Lesions of the Facial Nerve with Unfavorable Myographic Predictors. Russian Sklifosovsky Journal “Emergency Medical Care” (Zhurnal im. N.V. Sklifosovskogo). 2021;10(1):216–223. (In Russ.)]. https://doi.org/10.23934/2223-9022-2021-10-1-216-223Чехонацкая К.И., Завалий Л.Б., Синкин М.В., Семенов Л.Л., Рамазанов Г.Р., Петриков С.С. Клинический случай восстановления функции мимических мышц у пациента с идиопатическим поражением лицевого нерва при неблагоприятных миографических предикторах. Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2021;10(1):216–223. [Chekhonatskaya K.I., Zavaliy L.B., Sinkin M.V., Semenov L.L., Ramazanov G.R., Petrikov S.S. Clinical Case of Facial Muscles Function Recovery in a Patient with Idiopathic Lesions of the Facial Nerve with Unfavorable Myographic Predictors. Russian Sklifosovsky Journal “Emergency Medical Care” (Zhurnal im. N.V. Sklifosovskogo). 2021;10(1):216–223. (In Russ.)]. https://doi.org/10.23934/2223-9022-2021-10-1-216-223Саксонова Е.В., Орлова O.P., Куренков А.Л. Функциональная асимметрия нейро-моторного аппарата лица при невропатии лицевого нерва и ее коррекция ботулотоксином типа А. Журнал неврологии и психиатрии им. С.С. Корсакова. 2013;10:29–35. [Saxonova E.V., Orlova O.P., Kurenkov A.L. The functional combination of the neuromotor apparatus of the face in neuropathy of the facial nerve and correction with botulinum toxin type A. Journal of Neurology and psychiatry S.S. Korsakova. 2013;10:29–35. (In Russ.)]. https://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatrii-im-s-s-korsakova/2013/10/downloads/ru/031997-72982013105Саксонова Е.В., Орлова O.P., Куренков А.Л. Функциональная асимметрия нейро-моторного аппарата лица при невропатии лицевого нерва и ее коррекция ботулотоксином типа А. Журнал неврологии и психиатрии им. С.С. Корсакова. 2013;10:29–35. [Saxonova E.V., Orlova O.P., Kurenkov A.L. The functional combination of the neuromotor apparatus of the face in neuropathy of the facial nerve and correction with botulinum toxin type A. Journal of Neurology and psychiatry S.S. Korsakova. 2013;10:29–35. (In Russ.)]. https://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatrii-im-s-s-korsakova/2013/10/downloads/ru/031997-72982013105Ross B., Julian M. Efficacy of feedback training in long-standing facial nerve paresis. Laryngoscope. 1991;101(7):744–50. https://doi.org/10.1288/00005537-199107000-00009Ross B., Julian M. Efficacy of feedback training in long-standing facial nerve paresis. Laryngoscope. 1991;101(7):744–50. https://doi.org/10.1288/00005537-199107000-00009Dalla Toffola E., Tinelli C., Lozza A., Bejor M., Pavese C., Agosti D.I. et al. Choosing the best rehabilitation treatment for Bell’s palsy. Eur J Phys Rehabil Med. 2012;48(4):635–642. PMID: 22522431Dalla Toffola E., Tinelli C., Lozza A., Bejor M., Pavese C., Agosti D.I. et al. Choosing the best rehabilitation treatment for Bell’s palsy. Eur J Phys Rehabil Med. 2012;48(4):635–642. PMID: 22522431Beurskens C.H., Heymans P.G. Mime therapy improves facial symmetry in people with long-term facial nerve paresis: a randomised controlled trial.Australian J Physiother.2006;52(3):177–183. https://doi.org/10.1016/s0004-9514(06)70026-5Beurskens C.H., Heymans P.G. Mime therapy improves facial symmetry in people with long-term facial nerve paresis: a randomised controlled trial.Australian J Physiother.2006;52(3):177–183. https://doi.org/10.1016/s0004-9514(06)70026-5Nakamura K., Toda N., Sakamaki K., Kashima K., Takeda N. Biofeedback rehabilitation for prevention of synkinesis after facial palsy. Otolaryngol Head Neck Surg. 2003;128(4):539–543. https://doi.org/10.1016/s0194-5998(02)23254-4Nakamura K., Toda N., Sakamaki K., Kashima K., Takeda N. Biofeedback rehabilitation for prevention of synkinesis after facial palsy. Otolaryngol Head Neck Surg. 2003;128(4):539–543. https://doi.org/10.1016/s0194-5998(02)23254-4Dalla Toffola E., Bossi D., Buonocore M., Montomoli C., Petrucci L., Alfonsi E. Usefulness of BFB/EMG in facial palsy rehabilitation. Disabil Rehabil. 2005;27(14):809–815. https://doi.org/10.1080/09638280400018650dmehre H., Mirshamsi M., Mahmodi Z. Prevention of synkinesis by biofeedback therapy: a randomized clinical trial. Otol Neurotol. 2014;35(4):739–742. https://doi.org/10.1097/MAO.0000000000000217Dalla Toffola E., Bossi D., Buonocore M., Montomoli C., Petrucci L., Alfonsi E. Usefulness of BFB/EMG in facial palsy rehabilitation. Disabil Rehabil. 2005;27(14):809–815. https://doi.org/10.1080/09638280400018650dmehre H., Mirshamsi M., Mahmodi Z. Prevention of synkinesis by biofeedback therapy: a randomized clinical trial. Otol Neurotol. 2014;35(4):739–742. https://doi.org/10.1097/MAO.0000000000000217Pourmomeny A.A., Zadmehre H., Mirshamsi M., Mahmodi Z. Prevention of synkinesis by biofeedback therapy: a randomized clinical trial. Otol Neurotol. 2014;35(4):739–742. https://doi.org/10.1097/MAO.0000000000000217Pourmomeny A.A., Zadmehre H., Mirshamsi M., Mahmodi Z. Prevention of synkinesis by biofeedback therapy: a randomized clinical trial. Otol Neurotol. 2014;35(4):739–742. https://doi.org/10.1097/MAO.0000000000000217Pashov A. Paradigm shift in rehabilitation of long-standing Bell’s palsy during later stages of recovery. Fundamental and Applied Researches in Practice of Leading Scientific Schools. 2018;26(2):294–298. https://farplss.org/index.php/journal/article/view/348Pashov A. Paradigm shift in rehabilitation of long-standing Bell’s palsy during later stages of recovery. Fundamental and Applied Researches in Practice of Leading Scientific Schools. 2018;26(2):294–298. https://farplss.org/index.php/journal/article/view/348Pourmomeny A.A., Asadi S., Cheatsaz A. Management of Facial Synkinesis with a Combination of BTX-A and Biofeedback: A Randomized Trial. Iran J Otorhinolaryngol. 2015;27(83):409–415. PMID: 26788484Pourmomeny A.A., Asadi S., Cheatsaz A. Management of Facial Synkinesis with a Combination of BTX-A and Biofeedback: A Randomized Trial. Iran J Otorhinolaryngol. 2015;27(83):409–415. PMID: 26788484Katie A.F., Susan E.C. Effectiveness of electrical stimulation for rehabilitation of facial nerve paralysis. Physical Therapy Reviews. 2017;22(3):1–8. https://doi.org/10.1080/10833196.2017.1368967Katie A.F., Susan E.C. Effectiveness of electrical stimulation for rehabilitation of facial nerve paralysis. Physical Therapy Reviews. 2017;22(3):1–8. https://doi.org/10.1080/10833196.2017.1368967Volk G.F., Thielker J., Möller M.C., Majcher D., Mastryukova V., Altmann C.S. et al. Tolerability of facial electrostimulation in healthy adults and patients with facial synkinesis. Eur Arch Otorhinolaryngol. 2020;277(4):1247–1253. https://doi.org/10.1007/s00405-020-05818-xVolk G.F., Thielker J., Möller M.C., Majcher D., Mastryukova V., Altmann C.S. et al. Tolerability of facial electrostimulation in healthy adults and patients with facial synkinesis. Eur Arch Otorhinolaryngol. 2020;277(4):1247–1253. https://doi.org/10.1007/s00405-020-05818-xЗдыбский В.И. Рефлексотерапия при некоторых заболеваниях периферической нервной системы. Международный неврологический журнал. 2012;4(50):144–154. [Zdibskii V.I. Reflexology in the peripheral nervous system diseases. International neurological journal 2012;4(50):144–154. (In Russ.)].Здыбский В.И. Рефлексотерапия при некоторых заболеваниях периферической нервной системы. Международный неврологический журнал. 2012;4(50):144–154. [Zdibskii V.I. Reflexology in the peripheral nervous system diseases. International neurological journal 2012;4(50):144–154. (In Russ.)].Mancini R., Khadavi N.M., Goldberg R.A. Nonsurgical management of upper eyelid margin asymmetry using hyaluronic acid gel filler. Ophthal Plast Reconstr Surg. 2011;27(1):1–3. https://doi.org/10.1097/IOP.0b013e3181c2a16dMancini R., Khadavi N.M., Goldberg R.A. Nonsurgical management of upper eyelid margin asymmetry using hyaluronic acid gel filler. Ophthal Plast Reconstr Surg. 2011;27(1):1–3. https://doi.org/10.1097/IOP.0b013e3181c2a16dAdam W., Khasha T., Bradley P.G. Novel Long-term Therapy of Facial Synkinesis with Botulinum Neurotoxins Type A and Filler. J Clin Aesthet Dermatol. 2011;4(3):45–49. PMID: 21464887Adam W., Khasha T., Bradley P.G. Novel Long-term Therapy of Facial Synkinesis with Botulinum Neurotoxins Type A and Filler. J Clin Aesthet Dermatol. 2011;4(3):45–49. PMID: 21464887Choe W.J., Kim H.D., Han B.H., Kim J. Thread lifting: a minimally invasive surgical technique for long-standing facial paralysis. HNO. 2017;65(11):910–915. https://doi.org/10.1007/s00106-017-0367-3Choe W.J., Kim H.D., Han B.H., Kim J. Thread lifting: a minimally invasive surgical technique for long-standing facial paralysis. HNO. 2017;65(11):910–915. https://doi.org/10.1007/s00106-017-0367-3Navarrete M.L., Lоpez M.G., Torrent L., Issa D., Fernandez C. et al. Correction of Sequela on Facial Paralysis by Facial Threads and Hyaluronic Acid: Our Experience. Ann Clin Case Rep. 2021;6(1):1991.Navarrete M.L., Lоpez M.G., Torrent L., Issa D., Fernandez C. et al. Correction of Sequela on Facial Paralysis by Facial Threads and Hyaluronic Acid: Our Experience. Ann Clin Case Rep. 2021;6(1):1991.Coleman C.C. Surgical treatment of facial spasm. Ann Surg. 1937;105(5):647–657. https://doi.org/10.1097/00000658-193705000-00002Coleman C.C. Surgical treatment of facial spasm. Ann Surg. 1937;105(5):647–657. https://doi.org/10.1097/00000658-193705000-00002Marino H., Alurralde A. Spastic facial palsy; peripheral selective neurotomy. Br J Plast Surg. 1950;3(1):56–59. https://doi.org/10.1016/s0007-1226(50)80010-3Marino H., Alurralde A. Spastic facial palsy; peripheral selective neurotomy. Br J Plast Surg. 1950;3(1):56–59. https://doi.org/10.1016/s0007-1226(50)80010-3Guerrissi J.O. Selective myectomy for postparetic facial synkinesis. Plast Reconstr Surg. 1991;87(3):459–466. https://doi.org/10.1097/00006534-199103000-00010Guerrissi J.O. Selective myectomy for postparetic facial synkinesis. Plast Reconstr Surg. 1991;87(3):459–466. https://doi.org/10.1097/00006534-199103000-00010Laskawi R., Rohrbach S., Rоdel R. Surgical and nonsurgical treatment options in patients with movement disorders of the platysma. J Oral Maxillofac Surg. 2002;60(2):157–162. https://doi.org/10.1053/joms.2002.29810Laskawi R., Rohrbach S., Rоdel R. Surgical and nonsurgical treatment options in patients with movement disorders of the platysma. J Oral Maxillofac Surg. 2002;60(2):157–162. https://doi.org/10.1053/joms.2002.29810Chuang D.C., Chang T.N., Lu J.C. Postparalysis facial synkinesis: clinical classification and surgical strategies. Plast Reconstr Surg Glob Open. 2015;3(3):e320. https://doi.org/10.1097/GOX.0000000000000283Chuang D.C., Chang T.N., Lu J.C. Postparalysis facial synkinesis: clinical classification and surgical strategies. Plast Reconstr Surg Glob Open. 2015;3(3):e320. https://doi.org/10.1097/GOX.0000000000000283Azizzadeh B., Frisenda J.L. Surgical Management of Postparalysis Facial Palsy and Synkinesis. Otolaryngol Clin North Am. 2018;51(6):1169–1178. https://doi.org/10.1016/j.otc.2018.07.012Azizzadeh B., Frisenda J.L. Surgical Management of Postparalysis Facial Palsy and Synkinesis. Otolaryngol Clin North Am. 2018;51(6):1169–1178. https://doi.org/10.1016/j.otc.2018.07.012

The authors declare that there are no conflicts of interest present.