r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2022-27-4-27-36r-n-j-333Research ArticleИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL RESEARCHES AND CASE REPORTSИшемический инсульт на фоне легочных артериовенозных мальформацийIschaemic stroke associated with pulmonary arteriovenous malformationhttps://orcid.org/0000-0003-3124-2443БелопасоваА. В.BelopasovaA. V.

Москва

Moscow

https://orcid.org/0000-0001-6061-8118КулешА. А.KuleshA. A.

Кулеш Алексей Александрович

Пермь

Perm

aleksey.kulesh@gmail.comhttps://orcid.org/0000-0001-5679-4100МехряковС. А.MekhrykovS. A.

Пермь

Perm

https://orcid.org/0000-0002-8305-1115СыромятниковаЛ. И.SyromyatnikovaL. I.

Пермь

Perm

https://orcid.org/0000-0002-8726-8928ЧечеткинА. О.ChechetkinA. O.

Москва

Moscow

https://orcid.org/0000-0002-0274-9694КаршиеваА. Р.KarshievaA. R.

Москва

Moscow

https://orcid.org/0000-0003-3124-2443ДобрынинаЛ. А.DobryninaL. A.

Москва

Moscow

Научный центр неврологииРоссияResearch Center of NeurologyRussian FederationПермский государственный медицинский университет имени академика Е.А. Вагнера; Городская клиническая больница № 4РоссияPerm State Medical University named after Academician E.A. Wagner; 4th City Clinical Hospital of PermRussian FederationГородская клиническая больница № 4Россия4th City Clinical Hospital of PermRussian Federation2022031020222742736Copyright © Белопасова А.В., Кулеш А.А., Мехряков С.А., Сыромятникова Л.И., Чечеткин А.О., Каршиева А.Р., Добрынина Л.А., 20222022Белопасова А.В., Кулеш А.А., Мехряков С.А., Сыромятникова Л.И., Чечеткин А.О., Каршиева А.Р., Добрынина Л.А.Belopasova A.V., Kulesh A.A., Mekhrykov S.A., Syromyatnikova L.I., Chechetkin A.O., Karshieva A.R., Dobrynina L.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/333

Легочная артериовенозная мальформация (ЛАВМ) рассматривается в качестве редкой причины ишемического инсульта у пациентов молодого возраста. Представлена серия из 5 клинических случаев ЛАВМ-ассоциированного ишемического инсульта. Обсуждается патогенез заболевания, клиническая картина, подходы к диагностике и вторичной профилактике. Подробно описаны клинические случаи ишемического инсульта у пациентки 32 лет со спорадической ЛАВМ, которой выполнена эмболизация мальформации, и пациента 24 лет с наследственной геморрагической телеангиэктазией, которому при поступлении проведен внутривенный тромболизис и механическая тромбоэкстракция, а в последующем выполнена видеоторакоскопическая резекция ЛАВМ.

Pulmonary arteriovenous malformation (PAVM) is considered a rare cause of ischaemic stroke in young patients. In this article, we present a case series of 5 patients with PAVM-associated ischaemic stroke. We discuss pathophysiology, clinical presentation, diagnostic approaches, and secondary prevention. In addition, two of the aforementioned cases are provided in detail: the one of 32-year-old female with ischaemic stroke associated with sporadic PAVM, the latter being treated with embolization, and the one of 24-year-old male with hereditary hemorrhagic telangiectasia (HHT) who developed PAVM-associated ischaemic stroke, who was treated with intravenous thrombolytic therapy and mechanical thrombectomy on admission, followed by video-assisted thoracoscopic PAVM resection.

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The authors declare that there are no conflicts of interest present.