r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2022-27-1-106-112r-n-j-272Research ArticleИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL RESEARCHES AND CASE REPORTSКлинический случай энцефалита с антителами к NMDA-рецепторам на фоне новой коронавирусной инфекции (COVID-19)Clinical case of anti-NMDA receptor encephalitis associated with new coronaviral infection (COVID-19)https://orcid.org/0000-0002-9305-8679ХореваМ. А.KhorevaM. A.

Хорева Марина Александровна — к.м.н., доцент, доцент кафедры неврологии и нейрохирургии

Барнаул

Khoreva Marina Aleksandrovna — candidate of Medical Sciences, docent, Department of neurology and neurosurgery

Barnaul

marinakhoreva@mail.ruhttps://orcid.org/0000-0001-9844-0300СериковаИ. Ю.SerikovaI. Y.

Барнаул

Barnaul

https://orcid.org/0000-0002-7947-4529СмагинаИ. В.SmaginaI. V.

Барнаул

Barnaul

https://orcid.org/0000-0002-7626-6783ГоленкоА. А.GolenkoA. A.

Барнаул

Barnaul

https://orcid.org/0000-0002-3435-5331СмирновК. В.SmirnovK. V.

Барнаул

Barnaul

https://orcid.org/0000-0002-4415-6344ЗавьяловА. Е.ZavyalovA. E.

Барнаул

Barnaul

https://orcid.org/0000-0002-4712-3353ДраганикИ. А.DraganicI. A.

Барнаул

Barnaul

ФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава РоссииРоссияAltai state medical UniversityRussian FederationФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава России; КГБУЗ «Алтайский краевой клинический центр охраны материнства и детства»РоссияAltai state medical University; Altai Regional Clinical Center for Maternal and Child HealthRussian FederationКГБУЗ «Алтайский краевой клинический центр охраны материнства и детства»РоссияAltai Regional Clinical Center for Maternal and Child HealthRussian FederationФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава РоссииРоссияAltai state medical University; Altai Regional Clinical Center for Maternal and Child HealthRussian Federation202208032022271106112Copyright © Хорева М.А., Серикова И.Ю., Смагина И.В., Голенко А.А., Смирнов К.В., Завьялов А.Е., Драганик И.А., 20222022Хорева М.А., Серикова И.Ю., Смагина И.В., Голенко А.А., Смирнов К.В., Завьялов А.Е., Драганик И.А.Khoreva M.A., Serikova I.Y., Smagina I.V., Golenko A.A., Smirnov K.V., Zavyalov A.E., Draganic I.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/272

Во время текущей пандемии коронавирусной инфекции Coronavirus Disease 2019 (COVID-19) стало очевидным, что ее возбудитель Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) нередко приводит к поражению нервной системы. В литературе описаны случаи развития энцефалитов у пациентов с COVID-19, что является свидетельством возможного повреждения центральной нервной системы, связанного с SARS-CoV-2-инфекцией. В настоящее время в литературе гораздо выше оценивают вероятность иммуноопосредованных механизмов поражения центральной нервной системы, нежели прямое воздействие вируса SARS-CoV-2. Сообщения о развитии аутоиммунных энцефалитов, в частности энцефалита с антителами к NMDA-рецепторам у пациентов с COVID-19 в разном возрасте, могут быть подтверждением этих предположений. Представлен клинический случай развития энцефалита с антителами к NMDA-рецепторам на фоне SARSCoV-2-инфекции у 16-летней девушки. Это наблюдение показывает возможную связь между SARS-CoV-2-инфекцией и развитием аутоиммунного энцефалита.

During the outbreak of coronavirus disease 2019 (COVID-19) clinicians are increasingly involved in the observation of possible neurological complications due to the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some cases of encephalitis following COVID‐19 pandemic have been reported in literature that can mean possible damage to the central nervous system related to the SARS-CoV-2 infection. Early on, this was thought to be due to the direct effects of the virus itself, but the possibility of immune system mechanisms being implicated was gradually raised in scientific literature. The reports of anti‐NMDA receptor encephalitis among patients with COVID‐19 at different ages may be signs of this condition. We report the case of 16-year teenager with concomitant Anti-N-Methyl-D-Aspartate Receptor (Anti-NMDAR) encephalitis and COVID‐19. This clinical case brings arguments on the possible relationship between SARS-CoV-2 infection and autoimmune encephalitis.

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The authors declare that there are no conflicts of interest present.