r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2021-26-6-29-34r-n-j-241Research ArticleИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL RESEARCHES AND CASE REPORTSНейродегенеративные изменения сетчатки при болезни ПаркинсонаNeurodegenerative changes of retina in Parkinson diseasehttps://orcid.org/0000-0001-8070-7644ФедотоваЕ. Ю.FedotovaE. Yu.

Москва

Moscow

ekfedotova@gmail.comПолькинаН. В.PolkinaN. V.

Москва

Moscow

МихайловаЕ. Н.MikhailovaE. N.

Москва

Moscow

https://orcid.org/0000-0002-2704-6282ИллариошкинС. Н.IllarioshkinS. N.

Москва

Moscow

ФГБНУ «Научный центр неврологии»РоссияResearch Center of NeurologyRussian Federation2021060120222662934Copyright © Федотова Е.Ю., Полькина Н.В., Михайлова Е.Н., Иллариошкин С.Н., 20222022Федотова Е.Ю., Полькина Н.В., Михайлова Е.Н., Иллариошкин С.Н.Fedotova E.Y., Polkina N.V., Mikhailova E.N., Illarioshkin S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/241

При болезни Паркинсона (БП) показаны определенные структурные изменения сетчатки, визуализируемые с помощью оптической когерентной томографии (ОКТ). Среди них основное внимание привлекают атрофические изменения слоя нервных волокон сетчатки (СНВС). При этом диагностическая значимость метода ОКТ при БП до сих пор остается спорной.

Цель исследования

Цель исследования: исследовать толщину СНВС при БП с последующим определением значимости метода ОКТ для диагностики заболевания.

Материал и методы

Материал и методы. У пациентов с БП (n = 24) и в контрольной группе (n = 20) с помощью ОКТ была исследована толщина СНВС — средняя, в квадрантах и в 10 секторах.

Результаты

Результаты. У пациентов с БП выявлено истончение СНВС в нижнем квадранте по сравнению с контрольной группой (р = 0,009). Чувствительность и специфичность метода составили соответственно 56% и 82%. Толщина СНВС не была связана со сторонностью паркинсонической симптоматики, длительностью или тяжестью заболевания. В контрольной группе и у пациентов с БП отмечена связь толщины СНВС с возрастом.

Заключение

Заключение. БП характеризуется атрофическими изменениями сетчатки в виде истончения СНВС в нижнем квадранте, что подтверждает системность нейродегенеративной патологии при данном заболевании, выходящей за пределы черной субстанции и вещества головного мозга. При этом толщина СНВС показала ограниченную диагностическую значимость для выявления случаев данного заболевания.

In Parkinson’s disease (PD), some structural changes in the retina have been shown using optical coherence tomography (OCT). Among them most attractive are atrophic changes in retinal nerve fi ber layer (RNFL). However, diagnostic signifi cance of the OCT method in PD remains debatable.

Objective

Objective: to investigate a thickness of RNFL in Parkinson’s disease patients and to determine the signifi cance of the OCT method in the PD diagnostics.

Materials and methods

Materials and methods. In PD patients (n = 24) and in a control group (n = 20) OCT was used to study the thickness of RNFL — average, in quadrants and in 10 sectors.

Results

Results. In patients with PD thinning of RNFL in the inferior quadrant was revealed (p = 0.009). The sensitivity and specifi city of the method were 56% and 82%, respectively. The thickness of RNFL was not associated with parkinsonian symptoms asymmetry, duration and severity of the disease. In the control group and in PD patients, there was a relationship between the RNFL thickness and age.

Conclusion

Conclusion. PD is characterized by atrophic changes in the retina in the form of thinning of RNFL in the inferior quadrant, which confi rms the systemic nature of neurodegenerative pathology in this disease going beyond the substantia nigra and brain tissue. At the same time, the thickness of RNFL showed limited diagnostic value for detecting PD cases.

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The authors declare that there are no conflicts of interest present.