r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2021-26-6-16-28r-n-j-240Research ArticleИССЛЕДОВАНИЯ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL RESEARCHES AND CASE REPORTSМаркеры болезни Альцгеймера в почеркеMarkers of Alzheimer’s disease in handwritinghttps://orcid.org/0000-0002-4137-0660ЧерновЮ. Г.ChernovY. G.

Цюрих

Zurich

yc@ihs-sgg.chhttps://orcid.org/0000-0002-6041-2715ЖолдасоваЖ. А.ZholdasovaZh. A.

Алматы

 

Almaty

zhibek_zholdas@mail.ruИнститут научного исследования почеркаШвейцарияIHS Institute for Handwriting SciencesSwitzerlandТОО «Universal Brain Center»КазахстанLLP “Universal Brain Center”Kazakhstan2021060120222661628Copyright © Чернов Ю.Г., Жолдасова Ж.А., 20222022Чернов Ю.Г., Жолдасова Ж.А.Chernov Y.G., Zholdasova Z.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/240Цель исследования

Цель исследования. Болезнь Альцгеймера является самой распространенной формой деменции. Одним из потенциальных инструментов ранней индикации начинающегося заболевания является анализ почерка. Он может стать предупреждающим сигналом к серьезному врачебному исследованию. Динамика изменений почерка хорошо отражает также прогресс заболевания и эффективность терапии.

Материалы и методы

Материалы и методы. Авторами разработаны два соответствующих теста. Первый (AD-HS) позволяет оценить почерковые маркеры когнитивного расстройства и болезни Альцгеймера по имеющемуся образцу почерка. Второй (AD-HC) предназначен для оценки динамики при сравнении двух рукописных документов, написанных в разное время.

Результаты

Результаты. Пилотное исследование включает 16 пациентов, у которых в результате медицинского обследования было установлено заболевание на разных стадиях. Все они предоставили старые образцы своего почерка, датируемые 10–20 годами назад, и новые, специально написанные в рамках эксперимента. Оценка 36 характеристик почерка показала, что оба теста позволяют эффективно идентифицировать болезнь Альцгеймера и ее стадию. Корреляция между анализом почерка и результатом медицинского тестирования составила 0,62.

Заключение

Заключение. Дальнейшее усовершенствование предложенных тестов и расширение исследовательской базы позволят включать почерковедческие упражнения в поддерживающую терапию, замедляющую развитие заболевания.

The aim of the research

The aim of the research. Alzheimer’s disease is the most common form of dementia. One of the potential tools for early detection of the onset of the disease is the handwriting analysis. It can be a warning signal for a serious medical investigation. The dynamics of handwriting changes are also a good indicator of the progression of the disease and the eff ectiveness of therapy.

Methods

Methods. The authors have developed two corresponding tests. The fi rst (AD-HS) allows the assessment of handwriting markers of cognitive impairment and Alzheimer’s disease from an available handwriting sample. The second (ADHC) is designed to assess dynamics by comparing two handwritten documents written at diff erent times.

Results

Results. The pilot study includes 16 patients who were found to be at diff erent stages of the disease by medical examination. They all provided old handwriting samples dated 10–20 years ago and new handwriting samples specifi cally written as part of the experiment. Evaluation of 36 handwriting characteristics showed that both tests were eff ective in identifying Alzheimer’s disease and its stage. The correlation between the handwriting analysis and the medical test result was 0.62.

Conclusion

Conclusion. Further refi nement of the proposed tests and expansion of the research base will enable handwriting exercises to be incorporated into supportive therapy to slow the progression of the disease.

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The authors declare that there are no conflicts of interest present.