r-n-jРоссийский неврологический журналRussian neurological journal2658-79472686-7192МИА10.30629/2658-7947-2019-24-4-4-15r-n-j-20Research ArticleОБЗОРLITERATURE REVIEWВОЗМОЖНОСТЬ ИСПОЛЬЗОВАНИЯ ГЛИАЛЬНОГО ФИБРИЛЛЯРНОГО КИСЛОГО БЕЛКА КАК БИОМАРКЕРА В ОСТРОМ ПЕРИОДЕ ИНСУЛЬТАTHE POSSIBILITY OF USING GLIAL FIBRILLARY ACIDIC PROTEIN AS A BIOMARKER IN THE ACUTE PERIOD OF STROKEhttps://orcid.org/0000-0002-0175-3085ТопузоваМ. П.TopuzovaM. P.

канд.мед.наук, доцент кафедры неврологии и психиатрии, старший научный сотрудник НИЛ цереброваскулярной патологии НИО неврологии и нейрореабилитации

197341, Санкт-Петербург, ул. Аккуратова, 2

 

MD, PhD, Associate Professor of the Department of Neurology and Psychiatry, Senior Researcher of the Research Laboratory of  Cerebrovascular Pathology of the Research Department of Neurology and Neurorehabilitation

197341, Akkuratova street 2, Saint-Petersburg, Russia

topuzova_mp@almazovcentre.ruhttps://orcid.org/0000-0002-4441-1165АлексееваТ. М.AlekseevaT. M.

197341, Санкт-Петербург, ул. Аккуратова, 2

197341, Akkuratova street 2, Saint-Petersburg, Russia

https://orcid.org/0000-0003-3637-5405ПанинаЕ. Б.PaninaE. B.

197341, Санкт-Петербург, ул. Аккуратова, 2

197341, Akkuratova street 2, Saint-Petersburg, Russia

https://orcid.org/0000-0001-8537-3639ВавиловаТ. В.VavilovaT. V.

197341, Санкт-Петербург, ул. Аккуратова, 2

197341, Akkuratova street 2, Saint-Petersburg, Russia

https://orcid.org/0000-0002-6904-1746ПортикО. А.PortikO. A.

197341, Санкт-Петербург, ул. Аккуратова, 2

197341, Akkuratova street 2, Saint-Petersburg, Russia

https://orcid.org/0000-0003-1430-3195КовзелевП. Д.KovzelevP. D.

197341, Санкт-Петербург, ул. Аккуратова, 2

197341, Akkuratova street 2, Saint-Petersburg, Russia

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени B.A. Алмaзoвa» Минздрава РоссииРоссияFederal State Budgetary Institution «Almazov National Medical Research Centre» of the Ministry of Health of the Russian FederationRussian Federation20192910201904415Copyright © Топузова М.П., Алексеева Т.М., Панина Е.Б., Вавилова Т.В., Портик О.А., Ковзелев П.Д., 20192019Топузова М.П., Алексеева Т.М., Панина Е.Б., Вавилова Т.В., Портик О.А., Ковзелев П.Д.Topuzova M.P., Alekseeva T.M., Panina E.B., Vavilova T.V., Portik O.A., Kovzelev P.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.r-n-j.com/jour/article/view/20

Высокая смертность и инвалидизация в результате перенесенного инсульта во всем мире являются причиной поиска новых возможностей для улучшения ранней диагностики и оптимизации терапевтических подходов. Представлен обзор литературы, посвященной изучению глиального фибриллярного кислого белка (ГФКБ) в качестве биомаркера в остром периоде инсульта и возможности его использования для дифференцирования ишемического и геморрагического процесса, а также в целях определения степени разрушения мозговой ткани, как в первые часы инсульта, так и в динамике. Кроме того анализ ГФКБ может быть полезен для мониторинга течения заболевания, контроля над эффективностью проводимой терапии, а также с целью прогнозирования исходов.

High mortality and disability resulting from a stroke throughout the world is the cause of fi nding new opportunities to improve early diagnosis and optimize therapeutic approaches. The article presents a review of the literature devoted to the study of glial fi brillary acidic protein (GFAP) as a biomarker in the acute period of stroke, which showed that its use is possible not only to diff erentiate the ischemic and hemorrhagic process, but also to determine the degree of destruction of brain tissue, as in the fi rst hours of a stroke, and in the dynamics. In addition, the GFAP analysis can be useful for monitoring the course of the disease, control the eff ectiveness of therapy, as well as to predict outcomes.

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The authors declare that there are no conflicts of interest present.